Early assessment of diaphragmatic dysfunction in children in the ITU: chest radiology and phrenic nerve stimulation

Diaphragmatic dysfunction is a common postoperative complication of cardiac surgery in children, with important effects on respiratory morbidity. Its early diagnosis, followed by prompt surgical intervention, has been shown to reduce morbidity. However, the commonest method of diagnosis, based on hemi-diaphragmatic elevation on the chest radiograph, may be less accurate than direct techniques for assessing phrenic nerve function. We have compared electrophysiological and radiological diagnoses of diaphragmatic abnormality in 100 children (aged 3 days to 17.5 yrs) undergoing cardiac surgery, looking at respiratory morbidity as assessed by the duration of ventilation, the time spent on the cardiac intensive care unit (CICU), and the requirement for reintubation. Despite showing good reproducibility, radiological diagnosis was neither sensitive nor specific in identifying patients with electrophysiological phrenic nerve damage. Analysis of the measures of outcome supported the electrophysiological technique. Patients with electrophysiological evidence of damage had a longer duration of ventilation, spent longer on the CICU, and had a greater incidence of reintubation than either radiologically abnormal or "normal" patients. Chest X-rays are not a good method for diagnosing phrenic nerve damage in the early postoperative period in children. If early diagnosis is needed, then direct assessment of phrenic nerve function, such as the measurement of phrenic latency, may be a better technique.     

Heat denaturation of hemocytocardiotoxin from the venom of the Central Asian cobra

It has been stated that boiled for three hours haemocytocardiotoxin (HT) from cobra poison loses "direct" hemolytic activity and is unable to potentiate a haemolytic effect of phospholipase A. Surface activity of HT does not change. It is shown that in the course of heat denaturation the aggregation of toxin molecules to dimers and trimers takes place and electrophoretic mobility is decreased. The fluorescence of HT tyroxin residues supported the fact of its irreversible heat denaturation.     

泥页岩水化对岩石力学强度的影响

泥页岩经过水溶液浸泡,会因水化作用而膨胀,造成抗压强度、黏聚力、岩石强度及井壁稳定性下降,进而引起井壁失稳问题。进行单轴抗压试验和单轴抗拉试验,在不同离子类型及浓度的水溶液条件下,研究泥页岩的弹性模量、泊松比、破裂时的最大载荷值以及部分岩心的抗拉强度的变化趋势。实验结果表明在相同的试验条件下,泥页岩水化程度与钻井液类型有关,氯化钾钻井液对泥页岩的抑制作用最好。     

Cardiac transplantation in perspective for the future. Survival, complications, rehabilitation, and cost

Two hundred twenty-seven cardiac transplant procedures have been performed in 206 patients from January, 1968, to April, 1981. Postoperative survival rates, calculated by the actuarial method for program years 1968 to 1973 (66 patients), are 44%, 33%, 27%, 21%, and 18% at 1, 2, 3, 4, and 5 years after transplantation, respectively. Postoperative survival rates for program years 1974 to 1981 (140 patients) are 63%, 55%, 51, 44%, and 39% at 1, 2, 3, 4, and 5 years after transplantation, respectively. This increase results primarily from improvement in survival achieved in the first 3 postoperative months (59% +/- 7%, 1968 to 1973, versus 80% +/- 40%, 1974 to 1980), reflecting improved patient management. Infection remains the primary cause of death following transplantation (76/131 patients, 58%), followed by acute rejection (24/181, 18.3%), graft arteriosclerosis (14/131, 10.7%), and malignancy (6/131, 4.6%). The development of graft arteriosclerosis has been examined in 85 one-year survivors studied by annual coronary arteriograms. Coronary lesions of varying severity have developed in 21 patients. HLA-A2 incompatibility was associated with a higher incidence of graft arteriosclerosis than was apparent for all other A locus incompatibilities (p less than 0.0003). Lymphoma has been shown to be associated with younger recipient age, a primary disease diagnosis of idiopathic cardiomyopathy, and retransplantation. One hundred six patients have survived at least 1 year after transplantation; 97% were in NYHA Class 1 at that time interval and 82% returned to employment or activity of choice. The longest survival time is new 11 years, 3 months. Cardiac transplantation can be considered "reasonable and therapeutic treatment to extend life" in selected individuals.     

Parameter optimization for the Gaussian model of protein folding

Computational models of protein folding and ligand docking are large and complex. Few systematic methods have yet been developed to optimize the parameters in such models. We describe here an iterative parameter optimization strategy that is based on minimizing a structural error measure by descent in parameter space. At the start, we know the ‘correct’ native structure that we want the model to produce, and an initial set of parameters representing the relative strengths of interactions between the amino acids. The parameters are changed systematically until the model native structure converges as closely as possible to the correct native structure. As a test, we apply this parameter optimization method to the recently developed Gaussian model of protein folding: each amino acid is represented as a bead and all bonds, covalent and noncovalent, are represented by Hooke's law springs. We show that even though the Gaussian model has continuous degrees of freedom, parameters can be chosen to cause its ground state to be identical to that of Go-type lattice models, for which the global ground states are known. Parameters for a more realistic protein model can also be obtained to produce structures close to the real native structures in the protein database.     

Nitrous oxide "analgesia": resemblance to opiate action

Nitrous oxide produced a dose-related "analgesia" in mice (median effective dose, 55 percent). The analgesia was evaluated by means of a phenylquinone writhing test. Narcotic antagonists or chronic morphinization reduced nitrous oxide analgesia. Either nitrous oxide releases an endogenous analgesic or narcotic antagonists have analgesic antagonist properties heretofore unappreciated.     

气动上下料机械手手部结构的设计与分析

以炮弹径长自动检测生产线上搬运炮弹机械手的手部结构为研究对象,采用单片机对其气压驱动装置进行顺序控制,为保证结构设计的合理性,在论述系统组成、机械手运动、坐标形式及运动范围的基础上,运用有限元分析方法对手部结构进行分析和优化改进,结构设计满足验算结果要求.     

Effect of Relative Reduction on Property of Steel-Mushy Cu-Graphite Composite

The rolling treatment of steel-mushy QTi3.5-3.5 graphite composite was conducted under different relative reduction at room temperature. The effect of room-temperature rolling on interfacial mechanical property of steel-mushy QTi3.5-3.5 graphite composite was studied and the relationship between interfacial shear strength and relative reduction was established. The results show that, for steel-mushy QTi3.5-3.5 graphite composite, which consists of 1.2 mm-thick 08AI steel plate and 2.8 mm-thick QTi3.5-3.5 graphite layer, there is a nonlinear relationship between interfacial shear strength and relative reduction in graphite layer. When relative reduction is smaller than 1.1%, interfacial shear strength increases with increasing the relative reduction. When relative reduction is larger than 1.1%, interfacial shear strength decreases with increasing the relative reduction. When relative reduction is 1.1%, the largest interfacial shear strength of 145.2 MPa can be obtained.     

SLE4442 IC卡在自动加油机控制系统中的安全设计

SLE 4442 逻辑加密存储卡的加密机制依赖的只是保存在IC卡中的几位固定数字组成的卡密码，其抗破译和窃取的能力与应用系统的安全设计有着非常紧密的关系，本文以SLE4442 IC卡为具体研究对象，通过对其安全性进行分析，采用DES加密算法，系统全面地设计了一种逻辑加密卡安全应用体系，并将其应用在IC卡自动加油机控制系统中。     

USB技术及其在工业测控中的应用

介绍了USB技术的基本特点、传送方式和应用优势，并且简要说明USB技术在工业测控中的引入原因、应用思路和前景。