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71.
M.R. Lucas D.M. Tilbury 《The International Journal of Advanced Manufacturing Technology》2005,26(5):436-447
Currently there is a wide variety of logic control design methodologies used in industrial logic design. These methodologies include ladder diagrams, function block diagrams, sequential function charts, and flow charts, but driven by a desire for verifiability, academics are developing additional logic control design methodologies, such as modular finite state machines and Petri nets. Using these, important properties of programs can be verified and some logic can be generated automatically from a part plan. The main contribution of this paper is to define methods for measuring programs written in different methodologies, so that the performance of the methodologies can be compared.We demonstrate these methods of measurement using four program samples that perform similar functions on the same machine, written in four logic control design methodologies: ladder diagrams, Petri nets, signal interpreted Petri nets and modular finite state machines. 相似文献
72.
RW McCallum JD Chen Z Lin BD Schirmer RD Williams RA Ross 《Canadian Metallurgical Quarterly》1998,114(3):456-461
BACKGROUND & AIMS: No effective treatment is available for patients with gastroparesis refractory to standard medical therapy. The aim of this study was to investigate the effects of gastric pacing on gastric electrical activity, gastric emptying, and symptoms in patients with gastroparesis. METHODS: Nine patients with gastroparesis participated in this study. Four pairs of cardiac pacing wires were implanted on the serosa of the stomach. The protocol consisted of two portions: a temporary inpatient study period and an outpatient study for a period of 1 month or more. RESULTS: Gastric pacing entrained the gastric slow wave in all subjects and converted tachygastria in 2 patients into regular 3-cpm slow waves. Gastric emptying was significantly improved after the outpatient treatment with gastric pacing. The gastric retention at 2 hours was reduced from 77.0% +/- 3.3% to 56.6% +/- 8.6% (P < 0.05). Symptoms of gastroparesis were substantially reduced at the end of the outpatient treatment (1.51 +/- 0.46 vs. 2.84 +/- 0.61; P < 0.04). Eight of 9 patients no longer relied on jejunostomy tube feeding, and no adverse events were noted related to the pacing unit. CONCLUSIONS: Gastric pacing seems to be able to improve symptoms of gastroparesis and to accelerate gastric emptying in patients with gastroparesis. More controlled studies are necessary to further investigate the role of gastric pacing in clinical practice. 相似文献
73.
Andy Downton Jingyu He Simon Lucas 《International Journal on Document Analysis and Recognition》2007,9(2-4):263-279
The creation of structured digital libraries from paper-based archives is an area of growing demand in many scientific and
cultural fields, and is not satisfied either by off-the-shelf OCR or commercial form- processing systems. This paper describes
and evaluates a configurable archive construction system, which integrates document image pre-processing and analysis with
text post-processing tools and a standard OCR package to meet digital archiving requirements. The prototype system is currently
being used in conjunction with the UK Natural History Museum to help convert more than 500,000 cards of Lepidoptera (Butterflies
and Moths) and Coleoptera (Beetles) to searchable digital archives. Evaluation results covering different aspects of the system
from card scanning to overall word recognition rates for different database fields are summarised for two datasets comprising
over 5,000 cards selected from different parts of these archives. First-pass end-to-end word recognition rates of 70–90% are
reported for key data fields, subject to availability of suitable electronic dictionaries. Further validation and correction
is supported through web-editing of the online digital archive. 相似文献
74.
Marina Donate Luis Rodriguez Antonio De Lucas Juan F. Rodríguez 《International Journal of Refrigeration》2006,29(1):30-35
Mixtures of lithium bromide and organic salts of sodium and potassium (formate, acetate and lactate) have been evaluated as alternative absorbents for absorption refrigeration machines. The main objective is to overpass the limitations of lithium bromide and improve the characteristics and the efficiency of the refrigeration cycle. In order to select the mixture that presents better properties for its employment in absorption refrigeration cycles, a thermodynamic analysis have been done. Density, viscosity, enthalpies of dilution, solubility and vapour pressure data of the proposed mixtures have been measured. A simulation program has been developed to evaluate temperatures, heats exchanged in the different sections and the efficiency of the cycle. 相似文献
75.
Tatiana A.R. Silva Lucas F. Ferreira Letícia M. Souza Luiz R. Goulart João M. Madurro Ana G. Brito-Madurro 《Materials science & engineering. C, Materials for biological applications》2009,29(2):539-545
Immobilization and hybridization of oligonucleotides or specific-gene PCR product (DENV-1), a conserved genomic sequence of the dengue virus, onto graphite electrode modified with poly(4-hydroxyphenylacetic acid), were carried out with success using both direct electrochemical oxidation of guanine or redox electroactive indicator ethidium bromide.Studies of oligonucleotides hybridization with the complementary target showed a decrease of both guanosine and adenosine current peaks, when compared with the peak previously obtained before the hybridization. Immobilized ssDNA, DENV-1, was hybridized with various concentrations of target DNA. The interaction between DENV-1 hybridized onto the modified graphite electrodes surface and the intercalator, ethidium bromide, was observed by differential pulse voltammetry, monitoring the current change generated to the DNA intercalator accumulated onto the modified electrode after DNA hybridization. For the determination of complementary target, the proposed method exhibited a good dynamic range (12–42 nmol L? 1) and a low detection limit (7.12 nmol L? 1).AFM images showed that the oligonucleotides or single-stranded DNA, DENV-1, before hybridization, had roughness values lower than the double stranded obtained after hybridization.The new surface obtained in these work, as well as the possibility of utilization of the same to monitor hybridization events is a promising strategy for the development of DNA electrochemical biosensors. 相似文献
76.
Lucas Taoro-Gonzlez Daniel Pereda Catalina Valds-Baizabal Miriam Gonzlez-Gmez Jos A. Prez Ftima Mesa-Herrera Ana Canerina-Amaro Herminia Prez-Gonzlez Covadonga Rodríguez Mario Díaz Raquel Marin 《International journal of molecular sciences》2022,23(13)
Long-chain polyunsaturated fatty acids (LCPUFA), essential molecules whose precursors must be dietary supplied, are highly represented in the brain contributing to numerous neuronal processes. Recent findings have demonstrated that LCPUFA are represented in lipid raft microstructures, where they favor molecular interactions of signaling complexes underlying neuronal functionality. During aging, the brain lipid composition changes affecting the lipid rafts’ integrity and protein signaling, which may induce memory detriment. We investigated the effect of a n-3 LCPUFA-enriched diet on the cognitive function of 6- and 15-months-old female mice. Likewise, we explored the impact of dietary n-3 LCPUFAs on hippocampal lipid rafts, and their potential correlation with aging-induced neuroinflammation. Our results demonstrate that n-3 LCPUFA supplementation improves spatial and recognition memory and restores the expression of glutamate and estrogen receptors in the hippocampal lipid rafts of aged mice to similar profiles than young ones. Additionally, the n-3 LCPUFA-enriched diet stabilized the lipid composition of the old mice’s hippocampal lipid rafts to the levels of young ones and reduced the aged-induced neuroinflammatory markers. Hence, we propose that n-3 LCPUFA supplementation leads to beneficial cognitive performance by “rejuvenating” the lipid raft microenvironment that stabilizes the integrity and interactions of memory protein players embedded in these microdomains. 相似文献
77.
Antoine Rozenknop Roberto Wolfler Calvo Laurent Alfandari Daniel Chemla Lucas Létocart 《Journal of Scheduling》2013,16(6):585-604
This paper presents a heuristic method based on column generation for the EDF (Electricité De France) long-term electricity production planning problem proposed as subject of the ROADEF/EURO 2010 Challenge. This is to our knowledge the first-ranked method among those methods based on mathematical programming, and was ranked fourth overall. The problem consists in determining a production plan over the whole time horizon for each thermal power plant of the French electricity company, and for nuclear plants, a schedule of plant outages which are necessary for refueling and maintenance operations. The average cost of the overall outage and production planning, computed over a set of demand scenarios, is to be minimized. The method proceeds in two stages. In the first stage, dates for outages are fixed once for all for each nuclear plant. Data are aggregated with a single average scenario and reduced time steps, and a set-partitioning reformulation of this aggregated problem is solved for fixing outage dates with a heuristic based on column generation. The pricing problem associated with each nuclear plant is a shortest path problem in an appropriately constructed graph. In the second stage, the reload level is determined at each date of an outage, considering now all scenarios. Finally, the production quantities between two outages are optimized for each plant and each scenario by solving independent linear programming problems. 相似文献
78.
Anauara L. e Silva Lucas E. de Lima Terceiro Matheus F. de Lima Rafael Costa‐Silva Ednalva A. V. dos Santos Maria de Ftima Agra 《Microscopy research and technique》2020,83(3):287-296
Micromorphological studies were carried out using multiple microscopic techniques on the leaves and stem bark of Byrsonima sericea DC. (Malpighiaceae), a species popularly known as “murici” and used medicinally, in order to identify both qualitative and quantitative features of leaf and stem anatomy and histochemistry as differential parameters to support both the quality control of its ethnodrugs and the taxonomy of the genus. The study was conducted using traditional techniques of plant anatomy, histochemical tests, and the stomatal index (SI). Byrsonima sericea has hypostomatic leaves, anomocytic stomata, and its epidermal walls are anticlinal and straight on the adaxial and curved on the abaxial faces. T‐shaped trichomes were observed mainly on the abaxial surface. The leaf epidermis showed waxes syntopism on both surfaces, with the occurrence of different crystalloid forms on a single phylloplane. The mesophyll is dorsiventral, with 3‐4 collateral vascular bundles. Phenolic compounds, starch, and proteins were identified in the petiole and stem. The SI was 14.5 ± 0.53% (p < .05), but did not showed significant variations. A set of characters were found to be distinctive for the studied species, however, constituting parameters that could be used to separate B. sericea from other species of the genus. 相似文献
79.
Lucas Zago Naves David‐Alain Gerdolle Oswaldo Scopin de Andrade Marco Markus Maria Gresnigt 《Microscopy research and technique》2020,83(9):1118-1123
In restorative dentistry, the in situ replication of intra‐oral situations, is based on a non‐invasive and non‐destructive scanning electron microscopy (SEM) evaluation method. The technique is suitable for investigation restorative materials and dental hard‐ and soft‐tissues, and its interfaces. Surface characteristics, integrity of interfaces (margins), or fracture analysis (chipping, cracks, etc.) with reliable resolution and under high magnification (from ×50 to ×5,000). Overall the current study aims to share detailed and reproducible information about the replica technique. Specific goals are: (a) to describe detailed each step involved in producing a replica of an intra‐oral situation, (b) to validate an integrated workflow based on a rational sequence from visual examination, to macrophotography and SEM analysis using the replica technique; (c) to present three clinical cases documented using the technique. A compilation of three clinical situations/cases were analyzed here by means the replica technique showing a wide range of possibilities that can be reached and explored with the described technique. This guidance document will contribute to a more accurate use of the replica technique and help researchers and clinicians to understand and identify issues related to restorative procedures under high magnification. 相似文献
80.
Lucas Weißenborn Elie Richel Helena Hüseman Julia Welzer Silvan Beck Simon Schfer Heinrich Sticht Klaus Überla Jutta Eichler 《International journal of molecular sciences》2022,23(11)
Based on the structure of a de novo designed miniprotein (LCB1) in complex with the receptor binding domain (RBD) of the SARS-CoV-2 spike protein, we have generated and characterized truncated peptide variants of LCB1, which present only two of the three LCB1 helices, and which fully retained the virus neutralizing potency against different SARS-CoV-2 variants of concern (VOC). This antiviral activity was even 10-fold stronger for a cyclic variant of the two-helix peptides, as compared to the full-length peptide. Furthermore, the proteolytic stability of the cyclic peptide was substantially improved, rendering it a better potential candidate for SARS-CoV-2 therapy. In a more mechanistic approach, the peptides also served as tools to dissect the role of individual mutations in the RBD for the susceptibility of the resulting virus variants to neutralization by the peptides. As the peptides reported here were generated through chemical synthesis, rather than recombinant protein expression, they are amenable to further chemical modification, including the incorporation of a wide range of non-proteinogenic amino acids, with the aim to further stabilize the peptides against proteolytic degradation, as well as to improve the strength, as well the breadth, of their virus neutralizing capacity. 相似文献