Electric power distribution system design and planning in a deregulated environment

This study presents a hierarchical dynamic optimisation model to address the design, planning and energy scheduling problem in power distribution systems. In addition to planner controlled investments, uncoordinated investor distributed generation investments are also respected, for which recommendations given policies can be made. Beyond planning, this model's usefulness also extends into predicting the impact of different energy policies on system operation and economics.     

Nuclear magnetic resonance analysis of solution conformations in C4-V3 hybrid peptides derived from human immunodeficiency virus (HIV) type 1 gp120: relation to specificity of peptide-induced anti-HIV neutralizing antibodies

Immunogenic peptides containing epitopes of the gp120 C4 and V3 regions from human immunodeficiency virus strains MN and EV91 have been studied by nuclear magnetic resonance and molecular modeling and used as immunogens in rhesus monkeys. The results, combined with those for other peptides, suggest a correlation between solution conformation and immunologic cross-reactivity.     

Radial- and mixed-flow turbines for low head microhydro systems

This paper describes the design of two different specific speed microhydro turbines operating at heads between 6 and 12 m, at small scale and up to heads of 50 m at larger scales. The features are specifically tailored for ease of manufacture and uniquely resistant to debris blockage. Test machines are described and test results given; hydraulic efficiencies of over 70% have been achieved in all test models despite the fact that the turbine blades are made from flat plate, specifically to simplify manufacture. Outline drawings are given with key dimensions for each reference model, along with the equations for scaling to arbitrary sizes. These turbines are the mixed- and radial-flow members of a family of turbines developed to cover the microhydro range from 2 to about 50 m of head, which is below the range where Pelton wheels are applicable.     

Impact of speed change on estimated journey time: Failure of drivers to appreciate relevance of initial speed

Higher speeds are associated with increases in the probability of crashing and the severity of the outcome. Logically drivers speed to save time, and research evidence supports this assertion. It is therefore important to investigate drivers’ understanding of how speed change impacts on journey time. Since it is likely that drivers do not appreciate the reciprocal nature of the function which links these two variables, and its implications, two predictions can be made: the impact of a speed change will be underestimated at low speeds and overestimated at high speeds. This issue was addressed through four questions generated by manipulating Speed Change (increase versus decrease) and Starting Speed (30 mph versus 60 mph) with the participants being asked how they felt these variables would impact on journey time. These were included in a large survey addressing speed-related issues. Participants were a representative quota sample of 1005 UK drivers, interviewed by questionnaire. The findings indicated that three of the four questions produced results consistent with the predictions made. Furthermore, a repeated measures factorial ANOVA indicated that there was no real appreciation of how starting speed impacted on journey time. A disordinal interaction provided evidence that drivers wrongly believed that as starting speed increased the impact of a speed rise also increased; the opposite is true. For speed decreases, drivers appeared to think that starting speed had little impact on the amount of time saved. It is recommended that these findings be integrated into driver training and speed awareness courses.     

Demonstration of cellular aging and senescence in serially passaged long-term cultures of human trabecular osteoblasts

The proliferative capacity and cellular and biochemical characteristics of human trabecular bone osteoblasts were analysed throughout their replicative lifespan in vitro. Like several other cell types, human osteoblasts demonstrated a typical Hayflick phenomenon of cellular aging comprising a period of rapid proliferation until cumulative population doubling level (CPDL) 22 to 24, followed by a phase of slow growth and the final cessation of cell division at CPDL 32 to 34. Comparing young cells (less than 20% lifespan completed) and old cells (more than 90% lifespan completed) revealed a progressive increase in population doubling (PD) time, a decrease in attachment frequency, a decrease in the number of S-phase positive cells, a decrease in the rates of DNA, RNA and protein synthesis, an increase in the protein content per cell and an increased proportion of senescence-specific beta-galactosidase positive cells. While osteoblastic production of collagen type I decreased progressively during aging, alkaline phosphatase activity dropped rapidly after the first few passages and then remained constant during the rest of the proliferative lifespan, Significant morphological changes from thin and spindle-shaped early passage young cells to large, flattened and irregularly shaped late passage old cells full of intracellular debris were observed. In comparison, osteoblasts established from an osteoporotic bone sample showed a maximum CPDL of less than 5, had a longer PD time and exhibited abnormal senescent morphology. Thus, we have demonstrated for the first time that human osteoblasts, like several other diploid cell types, have a limited proliferative capacity in vitro and undergo aging and senescence as measured by various cellular and biochemical markers. In addition, preliminary studies show that cells from osteoporotic bone have a severely reduced proliferative capacity. This model of bone cell aging facilitates study of the molecular mechanisms of osteoblast senescence as well as factors related to osteoblast dysfunction in patients with osteoporosis.     

Breast-feeding exposure of infants to cadmium, lead, and mercury: a public health viewpoint

The purpose of this report is to provide an overview of the public health implications of exposure via breast milk to cadmium, lead, and mercury for nursing infants and to provide health-based guidance. Daily intakes were calculated and compared with guidance values used for public health assessments at hazardous waste sites. Cadmium, lead, and mercury under normal conditions are found in breast milk at concentration ranges of < 1 microgram/L, 2-5 micrograms/L, and 1.4-1.7 micrograms/L, respectively. Women exposed environmentally or occupationally can have higher levels in their breast milk. Concentrations of about 5 micrograms/L (cadmium), 20 micrograms/L (lead), and 3.5 micrograms/L (mercury) appear to be adequate screening levels. Many factors affect both the distribution of cadmium, lead, and mercury in breast milk and the health consequences to an infant. It is not clear what additional impact low-level exposure via breast milk may have on an infant born with a body burden to one of these metals. There is sufficient evidence to make the case that contaminated breast milk is a source of potential risk to infants in certain populations. Prevention strategies that include behavior modification and proper nutrition should be communicated to women at risk. Identification and elimination of exposure pathways and a critical analysis of the benefits of breast feeding versus heavy metal exposure are needed on a site-specific or individual basis. Research is required to better understand the impact of low-level exposure to heavy metals via breast milk. Breastfeeding should be encouraged under most circumstances.     

Fluoxetine increases norepinephrine release in rat hypothalamus as measured by tissue levels of MHPG-SO4 and microdialysis in conscious rats

The selective serotonin uptake inhibitor fluoxetine (10 mg/kg i.p.) increased tissue levels of the norepinephrine metabolite 3-methoxy-4-hydroxyphenylethylene glycol sulfate (MHPG-SO4) in rat hypothalamus, indicating an increased release of norepinephrine. Microdialysis studies in conscious rats showed that fluoxetine (10 mg/kg i.p.) increased extracellular concentrations of norepinephrine as well as serotonin in the hypothalamus. In contrast, desipramine (10 mg/kg i.p.) increased extracellular concentration of norepinephrine but not serotonin in the hypothalamus. Consistent with its mechanism of being a selective serotonin uptake inhibitor, local perfusion of fluoxetine (10 microM) caused a 7-fold increase in hypothalamic extracellular serotonin and a small non-significant increase in extracellular norepinephrine. The subsequent systemic injection of fluoxetine (10 mg/kg s.c.) after local perfusion caused a 3-fold increase in extracellular norepinephrine, indicating that fluoxetine's action leading to an increase in extracellular norepinephrine was not occurring in the terminal areas of the hypothalamus but elsewhere in the brain, possibly cell bodies in the locus coeruleus.