Socially acquired information reduces Norway rats' latencies to find food

Experiments have demonstrated that socially acquired information influences both where Norway rats, Rattus norvegicuslook for food and what foods they eat. The present studies were undertaken to determine whether rats could also use information acquired from conspecifics to determine when food had become available. Naive rats introduced either into colonies that had been trained to come to a feeding site when food was made available there or into colonies lacking such training. The former naive animals began to feed on introduced food with significantly shorter latencies than did the latter. Naive rats tended to leave a shelter they shared with others and travel to a feeding site after interacting at the shelter with a returning successful forager, but not after interacting there with a returning unsuccessful forager. Furthermore, naive rats that had been trained to eat a food, but not naive rats trained to avoid eating the same food, left shelter and went to a feeding site after interacting in the shelter with a returning forager that had eaten the food that naive rats had been trained either to eat or to avoid. All results were consistent with the view that naive colony members could learn that food had become available at a familiar feeding site by interacting with colony members that had recently eaten there.1997The Association for the Study of Animal Behaviour     

Antiatherogenic effect of estrogen abolished by balloon catheter injury in cholesterol-clamped rabbits

The purpose of this study was to investigate the importance of an intact endothelial cell layer for the direct antiatherogenic effect of estrogen on the arterial wall. Thirty rabbits were bilaterally ovariectomized and subjected to mechanical injury of the endothelium by balloon catheterization of the upper thoracic aorta. Immediately after the operation, treatment was initiated with either 17 beta-estradiol or placebo given intramuscularly. All rabbits were clamped at a similar plasma cholesterol level from 1 week before the operation until the experiment was terminated 13 weeks later. In the undamaged aorta, ie, the aortic arch, the lower thoracic aorta, and the upper abdominal aorta, the estrogen-treated rabbits had one third (P = .06), one sixth (P = .002), and one seventh (P = .001), respectively, the accumulation of cholesterol of the placebo-treated rabbits. In the upper thoracic aorta that had been subjected to mechanical injury of the endothelium, however, aortic cholesterol accumulation was not significantly different between the two groups. Similar results were obtained by histological evaluation of the aortic tissues. Immunohistochemical staining with antibodies against macrophages, smooth muscle cells, and T lymphocytes revealed no significant differences in the intimal distribution of cells between estrogen- and placebo-treated rabbits, except for a higher number of T lymphocytes per unit intimal area of the undamaged aortic arch (P < .0005) in the estrogen-treated-rabbits than the placebo-treated rabbits. This is the first study to demonstrate that the antiatherogenic effect of estrogen is abolished by balloon catheter injury in cholesterol-clamped rabbits. These results may indicate that an intact endothelial cell layer is crucial for the direct antiatherogenic effect of estrogen on the arterial wall.     

XXY male with X-linked dominant chondrodysplasia punctata (Happle syndrome)

Happle syndrome is an X-linked dominant disorder with presumed lethality in hemizygous males; familial occurrence is rare. We describe a family with Happle syndrome affecting individuals in 3 generations. A man in this family is the first known male patient with Happle syndrome. He is severely affected; this may be due to his 47,XXY karyotype.     

Mite allergen (Der p 1) concentration in houses and its relation to the presence and severity of asthma in a population of Sydney schoolchildren

The murine L5178Y (LY) lymphoma sublines, LY-R (radiation resistant) and LY-S (radiation sensitive) display a difference in susceptibility to camptothecin (CPT): LY-S cells are less sensitive to killing by this inhibitor of topoisomerase I than LY-R cells. Post-treatment (CPT present until 3 h after irradiation) sensitizes only LY-S cells. In agreement with this, only in LY-S cells is the relative number of DNA-protein cross-links formed after treatment with CPT + X higher than expected for additivity of X-ray and CPT-induced damage. The pattern of changes in the labelling indices and cell cycle distribution in cells that underwent combined treatment is essentially like that seen for single-agent treatment: for LY-S cells like that for radiation, for LY-R cells like that for CPT. We found no direct relation between the patterns of cell cycle distributions and the enhancement of the lethal effect of X-irradiation by CPT post-treatment. The sublines are not markedly differentially sensitive to beta-lapachone, which modifies topoisomerase I activity, and not sensitized to X-rays by post-irradiation treatment with the drug.     

Pharmacologic atrial natriuretic peptide reduces human leg capillary filtration

Atrial natriuretic peptide (ANP) is produced and secreted by atrial cells. We measured calf capillary filtration rate with prolonged venous-occlusion plethysmography of supine healthy male subjects during pharmacologic infusion of ANP (48 pmol/kg/min for 15 min; n = 6) and during placebo infusion (n = 7). Results during infusions were compared to prior control measurements. ANP infusion increased plasma [ANP] from 30 +/- 4 to 2,568 +/- 595 pmol/l. Systemic hemoconcentration occurred during ANP infusion: mean hematocrit and plasma colloid osmotic pressure increased 4.6 and 11.3%, respectively, relative to preinfusion baseline values (p < 0.05). Mean calf filtration, however, was significantly reduced from 0.15 to 0.08 ml/100 ml/min with ANP. Heart rate increased 20% with ANP infusion, whereas blood pressure was unchanged. Calf conductance (blood flow/arterial pressure) and venous compliance were unaffected by ANP infusion. Placebo infusion had no effect relative to prior baseline control measurements. Although ANP induced systemic capillary filtration, in the calf, filtration was reduced with ANP. Therefore, pharmacologic ANP infusion enhances capillary filtration from the systemic circulation, perhaps at upper body or splanchnic sites or both, while having the opposite effect in the leg.     

A motion illusion from two-dimensional periodic patterns

The spatial properties of a motion illusion (the Ouchi illusion) that occurs in a stationary pattern were examined by means of a variety of two-dimensional periodic patterns (formed by multiplying pairs of various one-dimensional periodic functions). In two experiments, observers rated the magnitude of the illusion. The results showed that (1) patterns having large energy and steep saddle-shaped contrast gradients tended to generate stronger illusions, (2) the composite pattern made up of the sum of the fundamental and harmonic components exhibited a stronger illusion than either the fundamental or the harmonic pattern, (3) patterns possessing an element orientation and phase shift similar to those of a rectangular checkerboard, and with element sizes of 15-50 min in width and 4-8 min in height yielded a larger illusion, (4) equiluminant colors largely abolished the effect, and (5) blurring the boundary between the test and surround did not reduce the illusion. Interactions between spatially overlapping ON and OFF units was discussed as a possible underlying cause of this phenomenon.     

An analysis of the effect of a reliability paradigm shift on leading British aerospace companies

The aerospace industry is moving towards a new paradigm for the statement of reliability specifications. This paradigm is not a technical metric inherent to a system in isolation, but rather encompasses the wider objectives, operational profile and logistic priorities of its customer. This customer focus is encapsulated in the metrics Failure Free Operating Period and Maintenance Free Operating Period. These metrics describe the duration of effective system operation, in the first case for systems where faults and maintenance are permitted and in the second for systems where faults may not be repaired. As part of the Department of Trade and Industry (DTI) funded Aerospace Project for Insertion of Reliability (ASPIRE) research programme, which itself is part of the Ultra Reliable Aircraft (URA) programme, representatives of leading aerospace companies were interviewed about their opinion n how this new reliability paradigm and associated concepts would affect their way of doing business and their engineering processes. It would appear that the aerospace industry is ready for a move to a more realistic set of reliability metrics and away from the old style MTBF based metrics. This sea change would most likely be welcomed by customers, but as yet the manufacturing companies are unconvinced that such a radical move would be a good thing. Much of the resistance to change is due to old‐fashioned, but well entrenched, beliefs in the traditional way of doing things. A move away from this would bring freshness to the industry and lead to cost and time savings as the traditional approach is dropped in favour of a more planned and thought out approach. Copyright © 2002 John Wiley & Sons, Ltd.     

Reinforcement of weakened cusps by adhesive restorative materials: an in-vitro study

Pairs of extracted premolar teeth were prepared with MOD cavities reducing the lingual cusp at its base to one of five widths: 1.25-2.25 mm. One of each pair was then restored with one of five adhesive restorative techniques and the weakened cusp of both teeth fractured by a force applied to the cusp at an angle of 30 degrees to the long axis of the tooth. At all cusp widths a layered restorative technique in which the cavities were filled to the enamel-dentine junction with glass-ionomer cement and the enamel replaced by composite, reinforced the weakened cusp more than the other restorative materials tested. This combination of materials to reinforce weakened cusps is worth considering as a cost effective alternative to removing the cusp entirely and making a crown or protecting the cusp with a cuspal coverage gold inlay.