Psychology and genetics: A happy marriage?

Presents a lecture delivered at the 1980 meeting of the Canadian Psychological Association. The present status of behavior genetics is reviewed. The nature-nurture issue is considered, and research on the genetic–environment interaction is advocated. Many hybrid sciences use reductionism to explain the phenomena of complex systems by the principles of the more basic sciences that deal with the component parts of these systems. A reductionistic view of behavior genetics is rejected; instead, the author prefers an approach that examines how biological factors directly influence behavior. Current trends in behavior genetics are identified. (French abstract) (24 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

A study of the vascular and acid-secretory responses of the rat gastric mucosa to histamine

1. The effects of histamine on gastric mucosal blood flow in the presence and absence of gastric acid secretion were studied in the rat. 2. Histamine, in doses greater than those required to stimulate maximal acid secretion, caused a small increase in mucosal blood flow per unit acid output. 3. When acid secretion was inhibited by methyl analogues of prostaglandin E2, histamine reduced arterial blood pressure and gave a dose dependent rise in mucosal blood flow. 4. When acid secretion was inhibited by the histamine H2-receptor antagonists, burimamide and metiamide, histamine still increased mucosal blood flow. 5. The use of H1-receptor antagonists to inhibit the histamine-induced hyperaemia was made difficult by their vasodilator actions. 6. The selective histamine H2-receptor agonist, 4-methyl histamine, had no effect on arterial blood pressure in doses which stimulated acid secretion. The increase in mucosal blood flow which accompanied the stimulation of acid secretion was inhibited by the anti-secretory prostaglandins and H2-receptor antagonists. 7. The selective histamine H1-receptor agonist, 2-pyridyl ethylamine, had no effect on acid output but increased resting mucosal blood flow. 8. These results suggest that histamine H2-receptors, primarily concerned with acid secretion, and H1-receptors concerned with vasodilatation are both present in the rat gastric mucosa.     

Effect of cetylpyridinium chloride on pathogenic fungi and Nocardia asteroides in sputum

The effect of cetylpyridinium chloride (CPC) on pathogenic fungi and Nocardia asteroides was studied. Sputa seeded with each of 11 organisms (Aspergillus flavus; Aspergillus fumigatus, Blastomyces dermatitidis, Candida albicans, Coccidioides immitis, Cryptococcus neoformans, Geotrichum candidum, Histoplasma capsulatum; Nocardia asteroides, Paracoccidioides brasiliensis, and Sporothrix schenckii) were treated with CPC and kept for 2, 5 and 9 days. The CPC reagent used (0.5% CPC and 0.5% sodium chloride) is one the Mycobacteriolgoy Branch at the Center for Disease Control added to sputa before shipping them to laboratories for recovery of mycobacteria. None of the organisms tested survived this treatment, and none was recovered on mycological or mycobacteriological media. Seeded sputa containing these organisms were also tested with a second CPC reagent (0.02% CPC and 0.5% sodium chloride) and held for 2, 5 and 9 days. A few colonies of A. flavus, A. fumigatus, and N. asteroides were recovered from these samples. Neither the morphology of the fungi nor their stainability by the fluorescent antibody method was affected by treatment with the reagent containing 0.5% CPC. However, the background material in smears from the 0.5% CPC-treated samples retained the conjugate, and this made weakly fluorescing organisms more difficult to detect. The 0.5% CPC treatment did not alter the morphology of N. asteroides or its ability to be stained with Kinyoun acid-fast stain.     

Oral and intramuscular phenytoin

After presenting the topographical and pathological basis for the habitual luxation of the shoulder joint, our experience with the Bankart-Müller operation on 38 of our own patients was described. The results are characterized as very good, particularly two years and longer after the operation.     

Immunocytochemical studies on Schistosoma mansoni. II. Soluble cercarial antigens in cercarial and schistosomules

The localization of soluble, cercarial antigen preparation (CAP) in cercariae and schistosomules of Schistosoma mansoni was performed at the light and electron microscope levels using the unlabeled antibody method. Reaction produce was observed associated with the contents of the pre- and postacetabular glands and with the filamentous coat of mature cercariae. No reaction product was observed associated with the glycoacalyx of schistosomules. However, several schistosomules did retain remnants of their filamentous coats and reaction product was observed associated with those remains. CAP components were also observed in the area surrounding the intrasporocyst cercariae.     

Hydroxyaliphatic acids in branched copolymers with acyl chloride-terminated long side chains: A new shrink-resist treatment for wool

Two synthetic routes were followed to prepare graft copolymers with long side chains containing acyl chloride terminal groups. In the first of these methods acryloxy aliphatic acyl chlorides were synthesized from ricinoleic acid, 12-hydroxystearic acid and 10-hydroxydecanoic acid and then polymerized with other acrylate ester comonomers. In the second procedure, a prepolymer was formed by copolymerizing acryloyl chloride with acrylate esters. The prepolymer then was treated with 12-hydroxystearic acid or 9(10)-hydroxymethylstearic acid to produce polymers with side chains having terminal carboxylic acid groups. These polymers were made more reactive by conversion to acid chlorides. The active polymers were applied to wool fabrics; the imparted shrink-resistance was durable under an accelerated wash test procedure. An added advantage of the treatment is a soft “hand” or feel resulting from internal plasticization of the polymer coating. No. Market. Nutr. Res. Div., ARS, USDA. W. Market, Nutr. Res. Div. ARS, USDA.