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41.
JakoB BJ orklund 《中国制造业信息化》2012,41(8):54-56
The industry now has a buzzword, "big data," for how we’re going to do something with the huge amount of information piling up. "Big data" is replacing "business 相似文献
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1 INTRODUCTIONTheγ TiAlbasedintermetallicalloyshavere centlyreceivedmoreandmoreattentionbecauseoftheirpotentialasadvancedhigh temperaturestruc turalmaterials.MicrostructurehasbeenfoundtohaveaconsiderableeffectonmechanicalpropertiesofTiAlalloys,whiledupl… 相似文献
44.
Dr. Simon J. A. Wiedemeyer Dr. Guojie Wu Dr. T. L. Phuong Pham Heike Lang-Henkel Benjamin Perez Urzua Prof. James C Whisstock Dr. Ruby H. P. Law Prof. Torsten Steinmetzer 《ChemMedChem》2023,18(6):e202200632
Two series of macrocyclic plasmin inhibitors with a C-terminal benzylamine group were synthesized. The substitution of the N-terminal phenylsulfonyl group of a previously described inhibitor provided two analogues with sub-nanomolar inhibition constants. Both compounds possess a high selectivity against all other tested trypsin-like serine proteases. Furthermore, a new approach was used to selectively introduce asymmetric linker segments. Two of these compounds inhibit plasmin with Ki values close to 2 nM. For the first time, four crystal structures of these macrocyclic inhibitors could be determined in complex with a Ser195Ala microplasmin mutant. The macrocyclic core segment of the inhibitors binds to the open active site of plasmin without any steric hindrance. This binding mode is incompatible with other trypsin-like serine proteases containing a sterically demanding 99-hairpin loop. The crystal structures obtained experimentally explain the excellent selectivity of this inhibitor type as previously hypothesized. 相似文献
45.
Lui Ng Sunny Kit-Man Wong Zheng Huang Colin Siu-Chi Lam Ariel Ka-Man Chow Dominic Chi-Chung Foo Oswens Siu-Hung Lo Roberta Wen-Chi Pang Wai-Lun Law 《International journal of molecular sciences》2022,23(3)
CD26 has been reported as a marker for colorectal cancer stem cells endowed with tumor-initiating properties and capable of colorectal cancer (CRC) metastasis. In this study, we investigated the functional effect of CD26 on CRC angiogenesis and metastasis, and the potential underlying mechanism. The functional effects of CD26 overexpression or repression were determined by a wound healing experiment, and cell migration and invasion assays in vitro and in mouse models. Differentially expressed genes regulated by CD26 were identified by genome-wide mRNA expression array and validated by quantitative PCR. CD26 functionally regulated CRC cell migration and invasion in vitro and angiogenesis and metastasis in vivo. Genome-wide mRNA expression array and qPCR showed that MMP1 was up-regulated in CD26+ subpopulation, and a subsequent experiment demonstrated the regulatory effect of CD26 on MMP1 in CRC cell lines with CD26 repression or overexpression. Furthermore, overexpression of CAV1 abrogated the CD26-regulated MMP1 induction in CRC cell lines. This study demonstrated the functional roles of CD26 in inducing CRC migration, invasion, angiogenesis and metastasis and identified the potential involvement of MMP1 and CAV1 in such process. CD26 is an attractive therapeutic target for combating tumor progression to improve the prognosis of CRC patients. 相似文献
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In the electrostatic application of pesticide sprays, charge retention by evaporating droplets in transit to deposit surfaces is a limiting problem. The possible charge loss via evaporative mass transfer and the possible alteration of evaporation rate caused by the presence of the droplet surface charge were experimentally investigated. For studies of evaporation from a charged 3 mm diameter water droplet conducted as a function of droplet potential (-1, -2, and -3 kV) and atmospheric relative humidity (22, 64, and 100%), the current flowing in the radial electric field of the charged evaporating was compared with that flowing in the radial field of a nonevaporating metal sphere to determine if the departing water vapor was electrified. It is concluded that electric charge on evaporating liquid droplets comprising agricultural chemical sprays neither alters the mass transfer rate nor is dissipated by the evaporation 相似文献
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The purpose of this research was to investigate the water absorption behavior and associated dimensional stability of kenaf‐polypropylene‐filled (PP/KF) composites. Composites with different fiber loadings, ranging from 0 to 40 wt %, were prepared with a twin‐screw extruder followed by hot press molding. The influence of the compatibilizer was also studied for PP/KF composite with 5 wt % maleated PP (MAPP). Water absorption testing was carried out at room temperature for 7 weeks. Tensile, flexural, and impact tests were also performed on control, wet, and re‐dried specimens. Increasing the fiber content resulted in higher water absorption and thickness swelling. The inferior mechanical properties of the wet composites were attributed to the effect of water, which deteriorates the interfacial properties of composites. On re‐drying, all properties were almost recovered because of the recovery of interfacial area as evident in scanning electron micrographs. Incorporation of the MAPP significantly improved the compatibility between the fiber and matrix and the mechanical properties of the composites compared with those without MAPP. It also diminished the water absorption as well as the related thickness swelling in the composites. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2010 相似文献
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伊拉克鲁迈拉油田CP00注水站设计规模为1 000 m3/h,注水压力为20 MPa。该注水站的设计方案及优化考虑了安全、环保、节能、节省投资等因素。重点介绍了CP00内向注水泵喂水的方案选择及设计优化,以及整体工艺流程的设计。 相似文献
49.
Kai P. Law Ting-Li Han Chao Tong Philip N. Baker 《International journal of molecular sciences》2015,16(5):10952-10985
Pregnancy-related complications such as pre-eclampsia and preterm birth now represent a notable burden of adverse health. Pre-eclampsia is a hypertensive disorder unique to pregnancy. It is an important cause of maternal death worldwide and a leading cause of fetal growth restriction and iatrogenic prematurity. Fifteen million infants are born preterm each year globally, but more than one million of those do not survive their first month of life. Currently there are no predictive tests available for diagnosis of these pregnancy-related complications and the biological mechanisms of the diseases have not been fully elucidated. Mass spectrometry-based proteomics have all the necessary attributes to provide the needed breakthrough in understanding the pathophysiology of complex human diseases thorough the discovery of biomarkers. The mass spectrometry methodologies employed in the studies for pregnancy-related complications are evaluated in this article. Top-down proteomic and peptidomic profiling by laser mass spectrometry, liquid chromatography or capillary electrophoresis coupled to mass spectrometry, and bottom-up quantitative proteomics and targeted proteomics by liquid chromatography mass spectrometry have been applied to elucidate protein biomarkers and biological mechanism of pregnancy-related complications. The proteomes of serum, urine, amniotic fluid, cervical-vaginal fluid, placental tissue, and cytotrophoblastic cells have all been investigated. Numerous biomarkers or biomarker candidates that could distinguish complicated pregnancies from healthy controls have been proposed. Nevertheless, questions as to the clinically utility and the capacity to elucidate the pathogenesis of the pre-eclampsia and preterm birth remain to be answered. 相似文献
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