Lycopene from two food sources does not affect antioxidant or cholesterol status of middle-aged adults

Background

Epidemiological studies have reported associations between reduced cardiovascular disease and diets rich in tomato and/or lycopene. Intervention studies have shown that lycopene-containing foods may reduce cholesterol levels and lipid peroxidation, factors implicated in the initiation of cardiovascular disease. The objective of this study was to determine whether consumption of lycopene rich foods conferred cardiovascular protection to middle-aged adults as indicated by plasma lipid concentrations and measures of ex vivo antioxidants.

Methods

Ten healthy men and women consumed a low lycopene diet with no added lycopene (control treatment) or supplemented with watermelon or tomato juice each containing 20 mg lycopene. Subjects consumed each treatment for three weeks in a crossover design. Plasma, collected weekly was analyzed for total cholesterol, high density lipoprotein cholesterol (HDL-C) and triglyceride concentrations and for the antioxidant biomarkers of malondialdehyde formation products (MDA), plasma glutathione peroxidase (GPX) and ferric reducing ability of plasma (FRAP). Data were analyzed using Proc Mixed Procedure and associations between antioxidant and lipid measures were identified by Pearson's product moment correlation analysis.

Results

Compared to the control diet, the lycopene-containing foods did not affect plasma lipid concentrations or antioxidant biomarkers. Women had higher total cholesterol, HDL-C and triglyceride concentrations than did the men. Total cholesterol was positively correlated to MDA and FRAP while HDL-C was positively correlated to MDA and GPX. GPX was negatively correlated to triglyceride concentration.

Conclusions

The inclusion of watermelon or tomato juice containing 20 mg lycopene did not affect plasma lipid concentrations or antioxidant status of healthy subjects. However, plasma cholesterol levels impacted the results of MDA and FRAP antioxidant tests.     

Cold sintering process: A new era for ceramic packaging and microwave device development

Cold sintering process (CSP) is an extremely low‐temperature sintering process (room temperature to ~200°C) that uses aqueous‐based solutions as transient solvents to aid densification by a nonequilibrium dissolution‐precipitation process. In this work, CSP is introduced to fabricate microwave and packaging dielectric substrates, including ceramics (bulk monolithic substrates and multilayers) and ceramic‐polymer composites. Some dielectric materials, namely Li₂MoO₄, Na₂Mo₂O₇, K₂Mo₂O₇, and (LiBi)_0.5MoO₄ ceramics, and also (1?x)Li₂MoO₄?xPTFE and (1?x)(LiBi)_0.5MoO₄?xPTFE composites, are selected to demonstrate the feasibility of CSP in microwave and packaging substrate applications. Selected dielectric ceramics and composites with high densities (88%‐95%) and good microwave dielectric properties (permittivity, 5.6‐37.1; Q × f, 1700‐30 500 GHz) were obtained by CSP at 120°C. CSP can be also used to potentially develop a new co‐fired ceramic technology, namely CSCC. Li₂MoO₄?Ag multilayer co‐fired ceramic structures were successfully fabricated without obvious delamination, warping, or interdiffusion. Numerous materials with different dielectric properties can be densified by CSP, indicating that CSP provides a simple, effective, and energy‐saving strategy for the ceramic packaging and microwave device development.     

How good are clinical MEDLINE searches? A comparative study of clinical end-user and librarian searches

The objective of this study was to determine the quality of MEDLINE searches done by physicians, physician trainees, and expert searchers (clinicians and librarians). Its design was an analytic survey with independent replication in a setting of self-service online searching from medical wards, an intensive care unit, a coronary care unit, an emergency room, and an ambulatory clinic in a 300-bed teaching hospital. Participating were all M.D. clinical clerks, house, and attending staff responsible for patients in the above settings. Intervention for all participants consisted of a 2-h small group class and 1-h practice session on MEDLINE searching (GRATEFUL MED) before free access to MEDLINE. Search questions from 104 randomly selected novice searches were given to 1 of 13 clinicians with prior search experience and 1 of 3 librarians to run independent searches (triplicated searches). Measurements and main results from these unique citations of the triplicated searches were sent to expert clinicians to rate for relevance (7-point scale). Recall (number of relevant citations retrieved from an individual search divided by the total number of relevant citations from all searches on the same topic) and precision (proportion of relevant citations retrieved in each search) were calculated. Librarians were significantly better than novices for both. Librarians had equivalent recall to, and better precision than, experienced end-users. Unexpectedly, only 20% of relevant citations were retrieved by more than one search of the set of three, with the conclusion that novice searchers on MEDLINE via GRATEFUL MED after brief training have relatively low recall and precision. Recall improves with experience but precision remains suboptimal. Further research is needed to determine the "learning curve," evaluate training interventions, and explore the non-overlapping retrieval of relevant citations by different searchers.     

模拟电路噪声源及其解决方法

模拟电路的噪声问题更多地依赖于经验而不像正规科学.设计人员经常遇到的情况就是电路的模拟硬件部分设计出来以后,却发现电路中的噪声太大,从而不得不进行重新设计和布线.     

Unraveling the Reasons for Efficiency Loss in Perovskite Solar Cells

The effect of the presence of unreacted PbI₂ on the perovskite solar cells efficiency is reported. N,N‐Dimethylformamide vapor treatment is introduced to study the influence of complete conversion to a power conversion efficiency of the device. It is discovered that the optimized morphology of the PbI₂ under layer is essential to form a dense perovskite layer preventing recombination by direct contact between TiO₂ and a hole transporting layer, and to increase the charge collection efficiency. The present findings provide an insight into the morphology and growth mechanism of perovskite layer, the correlation between the device performance, and the film deposition process.     

Influence of morphology on the behaviour of electrodes in a proton-conducting Solid Oxide Fuel Cell

SrCe_0.95Yb_0.05O₃ (SCY) and related materials are under consideration as a proton conductors for Solid Oxide Fuel Cell (SOFC) electrolytes. Sintered pellets of SCY are used to perform impedance spectroscopy (IS) studies and fuel cell tests on cells with Pt electrodes of two different morphologies. Electrodes are applied to the SCY pellets by two routes: either by firing on a layer of Pt paint (denoted electrode P) or by magnetron sputtering (electrode S). In impedance spectra recorded over a wide temperature range under humidified hydrogen, in symmetrical cell conditions, cells with S electrodes give rise to a much smaller low frequency impedance feature than the cells with P electrodes. This is tentatively attributed to faster diffusion-related processes taking place at the S electrodes. The behaviour of working fuel cells with S and P electrode morphologies is evaluated in terms of maximum power output and Area Specific Resistance in two-atmosphere tests. The fuel cell anode with the S morphology results in superior fuel cell performance, in agreement with the impedance study. The influence of the two different electrode morphologies on the behaviour of the cells is discussed with reference to their morphology, as determined by SEM and AFM.     

Application of layout and topology optimization using pattern gradation for the conceptual design of buildings

This paper explores the use of manufacturing-type constraints, in particular pattern gradation and repetition, in the context of building layout optimization. By placing constraints on the design domain in terms of number and variable size of repeating patterns along any direction, the conceptual design for buildings is facilitated. To substantiate the potential future applications of this work, examples within the context of high-rise building design are presented. Successful development of such ideas can contribute to practical engineering solutions, especially during the building design process. Examples are given to illustrate the ideas developed both in two-dimensional and three-dimensional building configurations.     

Natural ventilation in practice: linking facade design,thermal performance,occupant perception and control

The action of opening a window is the most intuitive and simple response to controlling overheating in a room. However, it relies on the vagaries of occupant interaction to exploit the passive design potential and achieve comfortable results. An understanding of occupant behaviour is thus of significance in the design and evaluation of naturally ventilated buildings. This paper demonstrates the link between facade design, thermal performance, occupant perception, and window use in naturally ventilated offices in summer, based on a pilot study monitoring offices in Cambridge, UK. Survey results indicate that facade design has a large impact on the occupants' perceived control over and satisfaction with their environments. The research reveals that there is a close connection between perceived control and actual control (with respect to window use), and that occupants with a high level of perceived control more frequently use their windows than others with a low level of perceived control. Positive feedback loops between occupant action and effect reinforce appropriate behaviour and the paper shows that it is possible to derive statistically significant behavioural models to predict window use for different facade conditions.

L'action d'ouvrir une fenêtre est la réponse la plus intuitive et la plus simple au problème du contrôle de la surchauffe d'une pièce. Néanmoins, elle est soumise aux caprices des interactions des occupants pour que soit exploité le potentiel de la conception passive et qu'il en résulte une température agréable. Comprendre le comportement des occupants n'est donc pas sans importance pour la conception et l'évaluation des bâtiments à ventilation naturelle. Cet article démontre le lien existant entre la conception des façades, les performances thermiques, la perception des occupants et l'utilisation des fenêtres dans les bureaux à ventilation naturelle en été, sur la base d'une étude pilote de suivi de bureaux à Cambridge, au Royaume-Uni. Les résultats de cette enquête indiquent que la conception des façades a une incidence importante sur le contrôle perçu de leur environnement par les occupants et sur leur satisfaction à l'égard de ce dernier. L'étude révèle qu'il existe un lien étroit entre contrôle perçu et contrôle réel (par rapport à l'utilisation des fenêtres) et que les occupants qui ont un niveau élevé de contrôle perçu utilisent plus fréquemment leurs fenêtres que ceux qui ont un faible niveau de contrôle perçu. Les boucles de feedback positif entre les actions des occupants et leurs effets renforcent le comportement adapté et l'article montre qu'il est possible d'en retirer des modèles comportementaux statistiquement significatifs permettant de prédire l'utilisation des fenêtres en fonction de l'état des façades.

Mots clés: comportement adaptatif, performances des bâtiments, conception des façades, ventilation naturelle, ventilation nocturne, comportement des occupants, perception des occupants, contrôle des fenêtres, Royaume-Uni