Topographically induced self-deformation of the nuclei of cells: dependence on cell type and proposed mechanisms

Osteosarcoma-derived cell lines (SaOs-2, MG63) have recently been shown to deform their nucleus considerably in response to surface topography. Such a deformation had not been described previously. Here we present results on additional cell lines, including cancerous (OHS4, U2OS), immortalized (F/STRO-1⁺A and FHSO6) and healthy cells (HOP). The cancerous cells were found to deform extensively, the immortalized cells showed small deformations, whereas the healthy cells showed deformation only at short incubation times. These results suggest a strong link between the malignant transformation of cells and the state of the cytoskeletal network. We propose mechanisms to explain the deformation in which the cytoskeleton either pushes down on the nucleus during spreading or pulls it down upon adhesion to the pillars.     

Characterizing distributed shared memory performance: a case studyof the Convex SPP1000

In a distributed shared memory (DSM) multiprocessor, the processors cooperate in solving a parallel application by accessing the shared memory. The latency of a memory access depends on several factors, including the distance to the nearest valid data copy, data sharing conditions, and traffic of other processors. To provide a better understanding of DSM performance and to support application tuning and compiler development for DSM systems, this paper extends microbenchmarking techniques to characterize the important aspects of a DSM system. We present an experiment-based methodology for characterizing the memory, communication, scheduling, and synchronization performance, and apply it to the Convex SPP1000. We present carefully designed microbenchmarks to characterize the performance of the local and remote memory, producer-consumer communication involving two or more processors, and the effects on performance when multiple processors contend for utilization of the distributed memory and the interconnection network     

Ambulatory cardiovascular activity in Vietnam combat veterans with and without posttraumatic stress disorder.

The present study investigated the relationship between daily diary affect ratings and ambulatory cardiovascular activity in 117 male Vietnam combat veterans (61 with posttraumatic stress disorder [PTSD] and 56 without PTSD). Participants completed 12–14 hr of ambulatory monitoring and daily diary affect ratings. Compared with veterans without PTSD, veterans with PTSD reported higher negative affect and lower positive affect in daily diary ratings. No differences were detected for mean laboratory initial recordings or mean ambulatory heart rate (HR), systolic blood pressure (SBP), or diastolic blood pressure (DBP). However, compared with veterans without PTSD, veterans with PTSD demonstrated higher SBP and DBP variability and a higher proportion of HR activity (compared with initial recording values) during daily activity. There was a significant Time of Day × Group interaction for mean HR, with a trend for PTSD participants to maintain HR levels during evening hours. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Large-scale mapping of boreal forest in SIBERIA using ERS tandem coherence and JERS backscatter data

Siberia's boreal forests represent an economically and ecologically precious resource, a significant part of which is not monitored on a regular basis. Synthetic aperture radars (SARs), with their sensitivity to forest biomass, offer mapping capabilities that could provide valuable up-to-date information, for example about fire damage or logging activity. The European Commission SIBERIA project had the aim of mapping an area of approximately 1 million km² in Siberia using SAR data from two satellite sources: the tandem mission of the European Remote Sensing Satellites ERS-1/2 and the Japanese Earth Resource Satellite JERS-1. Mosaics of ERS tandem interferometric coherence and JERS backscattering coefficient show the wealth of information contained in these data but they also show large differences in radar response between neighbouring images. To create one homogeneous forest map, adaptive methods which are able to account for brightness changes due to environmental effects were required. In this paper an adaptive empirical model to determine growing stock volume classes using the ERS tandem coherence and the JERS backscatter data is described. For growing stock volume classes up to 80 m³/ha, accuracies of over 80% are achieved for over a hundred ERS frames at a spatial resolution of 50 m.     

Application of regional earthquake mitigation optimization

A linear program was developed to help seismically active communities decide: (1) how much to spend on pre-earthquake mitigation that aims to reduce future losses versus waiting until after an event and paying for reconstruction, and (2) which of the many possible mitigation activities to fund so as to minimize overall risk. The mitigation alternatives considered are structural upgrading policies for groups of buildings. Benefits of mitigation are losses avoided in future earthquakes, including structural, non-structural, contents, and time-related losses, and casualties. The model is intended to be used as a tool to support the public regional mitigation planning process. In realistic applications, the model includes millions of variables, thus requiring a special solution method. This paper focuses on two efficient solution algorithms to solve the model—a Dantzig–Wolfe decomposition algorithm and a greedy heuristic algorithm. A comprehensive numerical study compares the two algorithms in terms of solution quality and solution time. The study shows that, compared to the Dantzig–Wolfe algorithm, the heuristic algorithm is much faster as expected, and provides comparable solution quality.     

Common and distinct patterns of affective response in dimensions of anxiety and depression.

The authors examined the time course of affective responding associated with different affective dimensions--anxious apprehension, anxious arousal, and anhedonic depression--using an emotion-modulated startle paradigm. Participants high on 1 of these 3 dimensions and nonsymptomatic control participants viewed a series of affective pictures with acoustic startle probes presented before, during, and after the stimuli. All groups exhibited startle potentiation during unpleasant pictures and in anticipation of both pleasant and unpleasant pictures. Compared with control participants, symptomatic participants exhibited sustained potentiation following the offset of unpleasant stimuli and a lack of blink attenuation during and following pleasant stimuli. Common and unique patterns of affective responses in the 3 types of mood symptoms are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

A bi-labeling based XPath processing system

We present BLAS, a Bi-LAbeling based XPath processing System. BLAS uses two labeling schemes to speed up query processing: P-labeling for processing consecutive child (or parent) axis traversals, and D-labeling for processing descendant (or ancestor) axis traversals. XML data are stored in labeled form and indexed. Algorithms are presented for translating XPath queries to SQL expressions. BLAS reduces the number of joins in the SQL query translated from a given XPath query and reduces the number of disk accesses required to execute the SQL query compared with the traditional XPath processing using D-labeling alone. We also propose an approximate P-labeling scheme and the corresponding query translation algorithm to handle XML data trees that contain a large number of distinct tag names, and/or are very deep. This extension captures a spectrum of XPath-to-SQL query translation schemes, ranging from existing schemes that do not use P-labels to the one that uses exact P-labels. Experimental results demonstrate the efficiency of the BLAS system.     

A practical look at ATPG

Book Reviewed: Digital Logic Testing and Simulation, 2nd edition, by Alexander Miczo (Wiley-Interscience, 2003, ISBN 0-471-43995-9, 696 pp., $115).