Technical note: changes in genetic predictions between subsequent evaluations

A procedure was developed to compute the proportion (P) of future genetic predictions that would be within 1 SE of previous predictions. The procedure is based on the Central Limit Theorem. Whatever the distribution function, provided only that it has a finite variance, the sample mean will have approximately the normal distribution for large samples. The proportion of new individual genetic predictions being within 1 SE of their previous evaluation is expressed as a function of the change in accuracy (ACC) between the previous and subsequent evaluations. If little additional information is made available since the previous evaluation, the increase in ACC will be almost negligible. As anticipated the vast majority of genetic predictions will be within 1 SE of their previous evaluation. The proportion determined from the results of the analysis can be compared to P. An additional appealing feature of the procedure presented is the ease of implementation with most computer softwares. Finally, application to both simulated and field data is presented.     

Hydrocephalus secondary to intracranial hemorrhage in premature infants

Premature (low birth weight) infants are particularly susceptible to intracranial hemorrhage. This frequently arises from the subependymal area and may dissect into the brain or into the ventricles. If the infant survives, hydrocephalus is a frequent sequela. Because of major improvements in the care of premature infants in recent years and the proliferation of intensive care nurseries, increasing numbers of low birth weight infants are surviving and developing hydrocephalus. Seven cases are described of infants who developed hydrocephalus following intracranial bleeding. Initially, ventricular and lumbar punctures were done to attempt to control head growth but this was unsuccessful. Two were treated with temporary external ventriculostomy which did not permanently control the hydrocephalus. Definitive treatment included ventriculo-atrial shunts using an expandable 'telescopic' cardiac catheter in two and ventriculoperitoneal shunts in five. The pathogenesis and management of the condition are discussed.     

Antibiotic sensitivity of the causative agents of pyelonephritis in pregnant and puerperal women

The data presented are evident of the fact that the causative agents of pyelonephritis in pregnant women and puerpera are mostly Ecsherichia. Ilebsiella, Enterococcus and Ps. aeruginosa were isolated not so often. Strains with multiple antibiotic resistance were mainly isolated from the urine. It should be noted that 64 per cent of the Klebsiella strains and 90 per cent of the Proteus strains were sensitive to ampicillin. It should be taken into account in development of rational therapy of pyelonephritis in pregnant women and puerpera.