Near‐Infrared Intraoperative Chemiluminescence Imaging

Intraoperative imaging technologies recently entered the operating room, and their implementation is revolutionizing how physicians plan, monitor, and perform surgical interventions. In this work, we present a novel surgical imaging reporter system: intraoperative chemiluminescence imaging (ICI). To this end, we have leveraged the ability of a chemiluminescent metal complex to generate near‐infrared light upon exposure to an aqueous solution of Ce⁴⁺ in the presence of reducing tissue or blood components. An optical camera spatially resolves the resulting photon flux. We describe the construction and application of a prototype imaging setup, which achieves a detection limit as low as 6.9 pmol cm^?2 of the transition‐metal‐based ICI agent. As a proof of concept, we use ICI for the in vivo detection of our transition metal tracer following both systemic and subdermal injections. The very high signal‐to‐noise ratios make ICI an interesting candidate for the development of new intraoperative imaging technologies.     

Relationship Between Structure and Coordination Strength of N and N,O-Hybrid Donor Ligands with Trivalent Lanthanides

ABSTRACT

To effectively separate lanthanides (Ln(III)) from actinides (An(III)), symmetrical 2,2′-bipyridyl (Bpy), 1,10-phenanthroline (Phen), and unsymmetrical N-methyl-N-tolyl-1,10-phenanthroline-2-carboxamide (MeTol-PTA) were investigated. According to the crystal structures and EXAFS experiments, the decreasing ionic radius from light to heavy Ln led to decreases in the Ln–N (Bpy) and Ln–N (Phen) distances, while log β simply increased due to the electrostatic interaction and the order of Ln–O (MeTol-PTA) < Ln–N (Bpy, Phen) < Ln–N (MeTol-PTA) was obtained. This indicated that the bulky phenanthroline moiety of MeTol-PTA may not allow N (MeTol-PTA) to come close to Ln. Consequently, the log β of MeTol-PTA exhibited a local maximum (around Nd).     

Comparative Assay of Antioxidant Packages for Dimer of Estolide Esters

A series of 26 different antioxidants and commercial antioxidant packages designed for petroleum‐based materials, containing both natural and synthetic‐based materials, were evaluated with dimeric coconut‐oleic estolide 2‐ethylhexyl ester (2‐EH), a bio‐based material. The different antioxidants were categorized into different classes of phenolic, aminic, and blended/others materials. The oxidation onset temperatures (OT) using non‐isothermal pressurized differential scanning calorimetry (PDSC) were measured and recorded under previously reported standard conditions. The aminic series gave the best resistance to oxidation as defined by the PDSC method with OT of 246.6 and 244.7 °C for the best two performers, which was a 38 °C improvement over the uninhibited or unformulated dimer estolide material. The phenolic series, containing most of the naturally occurring antioxidants, was the least successful formulation package for the dimer estolide. The blended/other materials, which were specifically designed for petroleum‐based lubricants, did not have the best OT, since the estolides and other bio‐based materials interact differently than their petroleum counterparts. A number of potential antioxidants have been identified as useful additives for the estolides esters. The OT of the estolide and formulated materials correlated well with other bio‐based materials such as biodiesel.     

Degradation of Thermal Barrier Coatings by Fuel Impurities and CMAS: Thermochemical Interactions and Mitigation Approaches

Degradation of free-standing yttria-stabilized zirconia (YSZ) and CoNiCrAlY coatings (300 μm) due to V₂O₅ and a laboratory-synthesized CMAS was investigated at temperatures up to 1400 °C. Reactions, phase transformations, and microstructural development in coatings were examined by using x-ray diffraction, scanning electron microscopy, and transmission electron microscopy. The molten deposits destabilized the YSZ and reacted with the thermally grown oxide with various phase transformations and reaction product formation. A dense, continuous environmental barrier overlay, based on oxides, applied by electrophoretic deposition was effective in mitigating the molten deposit attack. Enriching CMAS composition with Al promoted the crystallization of anorthite platelets and MgAl₂O₄ spinel, and mitigated CMAS ingression. EPD MgO overlay was also effective in protection against V₂O₅ melt by formation of magnesium vanadates. EPD alumina overlay deposited on thermal barrier coatings with APS 8YSZ and bond-coated IN939 superalloy retained its adhesion and structural integrity after prolonged furnace thermal cycle test at 1100 °C.     

Robust Transportation Network Design Under Demand Uncertainty

Abstract:   This article addresses the problem of a traffic network design problem (NDP) under demand uncertainty. The origin–destination trip matrices are taken as random variables with known probability distributions. Instead of finding optimal network design solutions for a given future scenario, we are concerned with solutions that are in some sense "good" for a variety of demand realizations. We introduce a definition of robustness accounting for the planner's required degree of robustness. We propose a formulation of the robust network design problem (RNDP) and develop a methodology based on genetic algorithm (GA) to solve the RNDP. The proposed model generates globally near-optimal network design solutions, f, based on the planner's input for robustness. The study makes two important contributions to the network design literature. First, robust network design solutions are significantly different from the deterministic NDPs and not accounting for them could potentially underestimate the network-wide impacts. Second, systematic evaluation of the performance of the model and solution algorithm is conducted on different test networks and budget levels to explore the efficacy of this approach. The results highlight the importance of accounting for robustness in transportation planning and the proposed approach is capable of producing high-quality solutions.     

Fuel cycle analysis of GFR using advanced fuels

The potential benefits of a synergistic light-water reactor (LWR) and gas-cooled fast reactor (GFR) fuel cycle were evaluated for its impact on the front-end and back-end of the fuel cycle. Comparisons were made with conventional once-through cycle (OTC) and MOX fuel cycle. Variations in the synergistic LWR/GFR fuel cycles were based on the degree of recycle in the LWR including both plutonium and reprocessed uranium with concomitant impact on used LWR fuel inventory. This provided a wide range in composition of GFR feed from low to high plutonium content with impact on transmutation/incineration within the GFR fuel cycle. Self-recycle of all actinides was modeled for the GFR with analyses demonstrating that the GFR can be sustained on and consequently accept a wide range of feed materials. Analyses were done using Monteburns along with MCNP and Origen2.2 to model a 60-year period corresponding to the anticipated lifetime of supposed contemporary LWRs and GFRs. All cycles were evaluated based on actinide total mass and isotopic inventory, radiotoxicity, heatload, and resource requirements including natural uranium and SWU. For comparison, all fuel cycles were normalized based on 1 TWHe output. Improvements in fuel cycle performance are dictated by the production and incineration of minor actinides in the GFR and their continued recycle may not be feasible due to the buildup of troublesome isotopes such as ²⁴⁴Cm and ²⁵²Cf. But where uranium and plutonium continue to be recycled beyond the 60-year period, the LWR/GFR cycles demonstrated order of magnitude reductions in used fuel inventories, heatload, and radiotoxicity on a per TWHe basis over LWR only cycles. The full details of the advanced fuel cycle methodology and results are presented.     

Limits on a bent waveguide for a wedge display

Wedge displays seem immune to slight bends even though they are likely to be introduced by the physical limits of the tools used for wedge manufacture. We show how the maximum angular error which can be introduced by a bend of constant curvature is determined by its thickness, radius of curvature, and the angle of the ray before entry into the bend. The maximum change in angle therefore depends on the number of bounces through the bend, not on how the ray enters. For a 500 lines VGA image of 20 mm thick curved part, the minimum acceptable radius of curvature is about 51.6 m. That Wedge panels seem able to tolerate more than this is probably because through a real bend, the radius of curvature varies.