Chronic malaria and splenic lymphoma: clues to understanding lymphoma evolution

In west Africa, splenic lymphoma with villous lymphocytes and hyper-reactive malarial splenomegaly have many clinical and immunological features in common suggesting an aetiopathological link. We hypothesize that in hyper-reactive malarial splenomegaly the dysregulated immune response to repeated malaria infections results in a stimulated, proliferating pool of B cells in which perturbation of cell growth and apoptosis by environmental and other factors promotes the development of SLVL. In Africa these factors are likely to include infectious agents several of which have already been associated with B-cell non-Hodgkin's lymphomas.     

Towards an automatic method of predicting protein stucture by homology: an evaluation of suboptimal sequence alignments

A major problem in predicting protein structure by homologymodelling is that the sequence alignment from which the modelis built may not be the best one in terms of the correct equivalencingof residues assessed by structural or functional criteria. Auseful strategy is to generate and examine a number of suboptimalalignments as better alignments can often be found away fromthe optimal. A procedure to filter rapidly suboptimal alignmentsbased on measurement of core volumes and packing pair potentialsis investigated. The approach is benchmarked on three pairsof sequences which are non-trivial to align correctly, namelytwo immunoglobulin domains, plastocyanin with azurin and twodistant globin sequences. It is shown to be useful to reducea large ensemble of possible alignments down to a few whichcorrespond more closely to the correct (structure based) alignment.     

DNA topology: topoisomerases keep it simple

The ability of type II DNA topoisomerases to perturb the equilibrium distributions of DNA topoisomers is a consequence of their ability to hydrolyse ATP. A sliding mechanism of topoisomerase action has been proposed to account for this phenomenon.     

Solution of Polynomial Systems Derived from Differential Equations

Nonlinear two-point boundary value problems arise in numerous areas of application. The existence and number of solutions for various cases has been studied from a theoretical standpoint. These results generally rely upon growth conditions of the nonlinearity. However, in general, one cannot forecast how many solutions a boundary value problem may possess or even determine the existence of a solution. In recent years numerical continuation methods have been developed which permit the numerical approximation of all complex solutions of systems of polynomial equations. In this paper, numerical continuation methods are adapted to numerically calculate the solutions of finite difference discretizations of nonlinear two-point boundary value problems. The approach taken here is to perform a homotopy deformation to successively refine discretizations. In this way additional new solutions on finer meshes are obtained from solutions on coarser meshes. The complicating issue which the complex polynomial system setting introduces is that the number of solutions grows with the number of mesh points of the discretization. To counter this, the use of filters to limit the number of paths to be followed at each stage is considered.     

The effects of overloads in fatigue crack growth

Several theories have been proposed to explain the transient fatigue crack growth decelerations and accelerations which follow overloads. The mechanisms that have been proposed to explain retardation after a tensile overload, for example, include residual stress, crack deflection, crack closure, strain hardening, and plastic blunting/resharpening. These mechanisms are reviewed in the light of recent experimental results, and implications with regard to their applicability are examined. It is suggested that no single mechanism can be expected to represent observed effects over the entire range of da/dN versus ΔK; eg, behaviour ranging from the near threshold region to the Paris region.     

Cognitive functioning in young "social drinkers": Is there impairment to detect?

Literature on the cognitive effects of nonexcessive alcohol use suggests that relatively high-quantity-per-occasion use may be related to subsequent decreases in sober-state abstracting skills in adults, but provides no clear prediction for youth. The need to identify persistent alcohol-intake effects on cognition is particularly acute for the period of adolescence and young adulthood because even slight damage may impair developmentally significant skills. We examine the relation between multiple measures of neuropsychological status and both continuous and categorical measures of alcohol-use patterns in an age- and sex-stratified sample of 1,308 18-, 21-, and 24-year-olds. The results of correlational and hierarchical regression analyses suggest that cognitive performance bears little direct relation to drinking behaviors in young nonclinical males and females. Although the data provide no strong support for the hypothesis of a causal relationship between alcohol use and cognitive functioning, there is a slight suggestion that frequent high-quantity consumption may become a salient parameter of use as subjects age. (PsycINFO Database Record (c) 2010 APA, all rights reserved)