米尔斯坦堂

正AAP学院米尔斯坦堂是位于纽约州伊萨卡市久负盛名的康奈尔大学建筑艺术和规划学院(简称"AAP学院")近百年来新建的第一栋建筑。但新建筑并没有独立于学院原有建筑,而是设计为与原有建筑室内外各层面相接的综合体。约4 400m2的空间内包含了工作室、展廊、评图室以及第一个专属礼堂等学院特别需要的空间。学院原有的4栋建筑位于校园北部边     

Invited review: Are adaptations present to support dairy cattle productivity in warm climates?

Environmental heat stress, present during warm seasons and warm episodes, severely impairs dairy cattle performance, particularly in warmer climates. It is widely viewed that warm climate breeds (Zebu and Sanga cattle) are adapted to the climate in which they evolved. Such adaptations might be exploited for increasing cattle productivity in warm climates and decrease the effect of warm periods in cooler climates. The literature was reviewed for presence of such adaptations. Evidence is clear for resistance to ticks and tick-transmitted diseases in Zebu and Sanga breeds as well as for a possible development of resistance to ticks in additional breeds. Development of resistance to ticks demands time; hence, it needs to be balanced with potential use of insecticides or vaccination. The presumption of higher sweating rates in Zebu-derived breeds, based upon morphological differences in sweat glands between breeds, has not been substantiated. Relatively few studies have examined hair coat characteristics and their responses to seasonal heat, particularly in temperate climate breeds. Recently, a gene for slick hair coat has been observed that improved heat tolerance when introduced into temperate climate breeds. No solid evidence exists that hair coat in these lines is lighter than in well-fed warm climate-adapted Holsteins. Warm climate breeds and their F1 crosses share as dominant characteristics lower maintenance requirements and milk yields, and limited response to improved feeding and management. These characteristics are not adaptations to a feed-limited environment but are constitutive and useful in serving survival when feed is scarce and seasonal and high temperatures prevail. The negative relationship between milk yield and fertility present in temperate climates breeds also prevails in Zebu cattle. Fertility impairment by warm conditions might be counteracted in advanced farming systems by extra corporeal early embryo culture. In general, adaptations found in warm climate cattle breeds did not increase heat dissipation capacity, but rather diminished climate-induced strain by decreasing milk production. The negative relationship between reproductive efficiency and milk yield, although relatively low, also appears in Zebu cattle. This association, coupled with limited feed intake, acting over millennia, probably created the selection pressure for a low milk production in these breeds.     

Extracorporeal shock wave treatment for chronic calcific tendinitis of the shoulder

OBJECTIVE: To study the clinical and radiological response of chronic calcific tendinitis of the shoulder to extracorporeal shock wave treatment (ESWT). METHODS: The study included 3 female patients, 42, 48, and 50 years of age, all with calcified tendinitis of the rotator cuff. All had severe shoulder pain and limitation of motion. ESWT was done in one session with an extracorporeal shock wave lithotripter. RESULTS: After 24 hours, a fragmentation of calcification was achieved, and the patients had no pain and had entirely regained their joint movement. After 2 years of followup they were clinically and radiologically asymptomatic, and there were no adverse effects or other complications. CONCLUSION: With its good tolerance, safety, and clinical and radiologic response, ESWT should be considered as an alternative therapy in the treatment of chronic calcific tendinitis of the shoulder refractory to other therapies.     

Effects of inconsistencies in eyewitness testimony on mock-juror decision making.

In attempting to impeach an eyewitness, attorneys often highlight inconsistencies in the eyewitness's recall. This study examined the differential impact of types of inconsistent testimony on mock juror decisions. Participants viewed 1 of 4 versions of a videotaped trial in which the primary evidence against the defendant was the testimony of the eyewitness. The types of inconsistent statements given by the eyewitness in the 4 versions were manipulated: (a) consistent testimony, (b) information given on the stand but not during the pretrial investigation, (c) contradictions between on-the-stand and pretrial statements, and (d) contradictions made on the stand. Participants exposed to any form of inconsistent testimony were less likely to convict and found the defendant less culpable and the eyewitness less effective. These effects were larger for contradictions than for information given on the stand but not during pretrial investigations. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Specific and differential activation of mitogen-activated protein kinase cascades by unfamiliar taste in the insular cortex of the behaving rat

Rats were given to drink an unfamiliar taste solution under conditions that result in long-term memory of that taste. The insular cortex, which contains the taste cortex, was then removed and assayed for activation of mitogen-activated protein kinase (MAPK) cascades by using antibodies to the activated forms of various MAPKs. Extracellular responsive kinase 1-2 (ERK1-2) in the cortical homogenate was significantly activated within <30 min of drinking the taste solution, without alteration in the total level of the ERK1-2 proteins. The activity subsided to basal levels within <60 min. In contrast, ERK1-2 was not activated when the taste was made familiar. The effect of the unfamiliar taste was specific to the insular cortex. Jun N-terminal kinase 1-2 (JNK1-2) was activated by drinking the taste but with a delayed time course, whereas the activity of Akt kinase and p38MAPK remained unchanged. Elk-1, a member of the ternary complex factor and an ERK/JNK downstream substrate, was activated with a time course similar to that of ERK1-2. Microinjection of a reversible inhibitor of MAPK/ERK kinase into the insular cortex shortly before exposure to the novel taste in a conditioned taste aversion training paradigm attenuated long-term taste aversion memory without significantly affecting short-term memory or the sensory, motor, and motivational faculties required to express long-term taste aversion memory. It was concluded that ERK and JNK are specifically and differentially activated in the insular cortex after exposure to a novel taste, and that this activation is required for consolidation of long-term taste memory.     

Psychotherapy for the treatment of depression: A comprehensive review of controlled outcome research.

Previous quantitative reviews of research on the efficacy of psychotherapy for depression have included only a subset of the available research or limited their focus to a single outcome measure. The present review offers a more comprehensive quantitative integration of this literature. Using studies that compared psychotherapy with either no treatment or another form of treatment, this article assesses (1) the overall effectiveness of psychotherapy for depressed clients, (2) its effectiveness relative to pharmacotherapy, and (3) the clinical significance of treatment outcomes. Findings from the review confirm that depressed clients benefit substantially from psychotherapy, and these gains appear comparable to those observed with pharmacotherapy. Initial analysis suggested some differences in the efficacy of various types of treatment; however, once the influence of investigator allegiance was removed, there remained no evidence for the relative superiority of any 1 approach. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Electrospray mass spectrometry: application of ion evaporation theory to amino acids

We describe the result of applying the ion evaporation theory to a series of amino acids. The very good correlation (r = 0.98) of the natural logarithms of protonated molecule intensities observed by electrospray with the difference between the hydration free energies of molecules and the gas-phase binding free energies of molecules and protons in amino acids is consistent with the ion evaporation model. It seems that the difference in the protonated molecule intensities of amino acids obtained by electrospray can be explained by a scheme in which protonated molecules in the liquid phase are extracted into the gas phase after a charged droplet is formed.