When and how perfectionism impedes the brief treatment of depression: Further analyses of the National Institute of Mental Health Treatment of Depression Collaborative Research Program.

Perfectionism has previously been identified as having a significant negative impact on therapeutic outcome at termination in the brief (16-week) treatment of depression (S. J. Blatt, D. M. Quinlan, P. A. Pilkonis, & T. Shea, 1995) as measured by the 5 primary outcome measures used in the National Institute of Mental Health Treatment of Depression Collaborative Research Program (TDCRP). The present analyses of other data from the TDCRP indicated that this impact of perfectionism on therapeutic outcome was also found in ratings by therapists, independent clinical evaluators, and the patients and that this effect persisted 18 months after termination. In addition, analyses of comprehensive, independent assessments made during the treatment process indicated that perfectionism began to impede therapeutic gain in approximately 2/3 of the sample, in the latter half of treatment, between the 9th and 12th sessions. Implications of these findings are discussed, including the possibility that more perfectionistic patients may be negatively impacted by anticipation of an arbitrary, externally imposed termination date. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Self‐Cleaning and Antibacteric Ceramic Tile Surface

The aim of this investigation was the surface functionalization of industrial ceramic tiles by sol‐gel technique to improve at the same time the cleanability and the antibacterial activity of surfaces. This objective was pursued through the design and preparation of nanostructured titania‐silver coating that was deposited on glazed, unglazed, and polished tiles by air‐brushing. The obtained results showed that the applied coatings are transparent, show a good adhesion, and a remarkable antibacterial activity under the tested conditions. The surface photocatalicity was optimized with the higher thermal treatments (200°C) even if photodegradation process is clearly affected by the sample surface roughness.     

Deterioration of generic knowledge in patients with Alzheimer's disease: evidence from the Number Information Test

Semantic memory for generic knowledge was assessed in patients with probable Alzheimer's disease (AD; n = 142) and elderly normal control (NC; n = 78) subjects using the Number Information Test (NIT), a test that consists of 24 general knowledge questions that require a single number for an answer (e.g., "How many days are in a year?"). The results showed that patients with AD were impaired, even in the mildest stage of dementia, and that this impairment grew as the severity of their dementia increased over time. In addition, patients with AD were highly consistent in the individual items they missed in subsequent test sessions conducted 1 or 2 years later. These results indicate that semantic memory for generic knowledge is impaired relatively early in AD, deteriorates throughout the course of the disease, and may be due to a loss of knowledge rather than to a retrieval deficit.     

Research in environmental radioactivity studies

A survey of the tissue and subcellular distribution of some enzyme activities of mixed-function oxygenase (MFO) and benzo [a] pyrene (BP) metabolism in Mytilus edulis has been carried out. Subcellular fractions were characterized by marker enzymes (pyruvate kinase, β-N-acetylglucoseaminidase, succinic dehydrogenase and glycose-6-phosphatase) and electron microscopy. The tissues examined in male and female mussels were the digestive gland, gills, mantle, posterior adductor muscle, foot, ‘rest’ fraction and blood cells. Evidence was obtained that in the female digestive gland in particular a signifant fraction of the microsomes co-sedimented with the mitochondria at 12 000 × g and some solubilization of the endoplasmic reticulum also occurred during homogenization and extraction. MFO activities and cytochromes were localized in the microsomes. Cytochrome P-450 was present only in the digestive gland and the P-450-associated activities were highest in this tissue. In contrast cytochrome b₅ was also present in the gills and mantle. The activities were higher in the digestive gland microsomes of female mussels than of males and were in females (means ± SEM, n = 4): 7.5 ± 0.7 (glucose-6-phosphate dehydrogenase), 930.2 ± 54.6 (NADH-ferricyanide reductase), 156.5 ± 9.5 (NADH-cytochrome c reductase) and 18.4 ± 4.6 (NADPH-cytochrome c reductase) (all in nmol min^?1 mg^?1 protein at 25°C); 31.0 ± 3.9 (BP hydroxylase, pmol min^?1 mg^?1 protein at 25°C); 75.5 ± 11.7 (b₅) and 134 ± 64 (P-450) (in pmol mg^?1 protein and both the pooled material of both sexes, n = 4). Digestive gland microsomal BP hydroxylase activity was partially inhibited by carbon monoxide, SKF-525A and α-naphtoflavone. Based on this evidence and an observed relationship between microsomal BP hydroxylase and NADPH-cytochrome c reductase activities, it is concluded that a cytochrome P-450 mediated MFO system is present in mussels.     

Vulnerability to depression: Reexamining state dependence and relative stability.

Treatment-related decreases in Dysfunctional Attitudes Scale (DAS; Weissman & Beck, 1978) scores have been interpreted as evidence that dysfunctional attitudes are state-dependent concomitants of depression. Data from the National Institute of Mental Health Treatment of Depression Collaborative Research Program were used to reexamine the stability of dysfunctional attitudes. Mean scores for Perfectionism, Need for Approval, and total DAS decreased after 16 weeks of treatment. However, test–retest correlations showed that the DAS variables displayed considerable relative stability. Structural equation models demonstrated that dysfunctional attitudes after treatment were significantly predicted by initial level of dysfunctional attitudes as well as by posttreatment depression. The relative stability of dysfunctional attitudes was even higher during the 18-month follow-up period. The results were consistent with Beck's (1967) and Blatt's (1974) theories of vulnerability. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Cognitive and neuropathologic correlates of Stroop Color-Word Test performance in Alzheimer's disease.

The Stroop Color-Word Test (SCWT; C. Golden, 1978) was examined in 59 patients with probable Alzheimer's disease (AD) and in 51 demographically comparable normal control (NC) participants. AD patients produced significantly larger Stroop interference effects than NC participants, and level of dementia severity significantly influenced SCWT performance. Principal -components analyses demonstrated a dissociation in the factor structure of the Stroop trials between NC participants and AD patients, suggesting that disruption of semantic knowledge and speeded verbal processing in AD may be a major contributor to impairment on the incongruent trial. Results of clinicopathologic correlations in an autopsy-confirmed AD subgroup further suggest the invocation of a broad network of integrated cortical regions and executive and language processes underlying successful SCWT performance. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Contributions of frontal system dysfunction to memory and perceptual abilities in Parkinson's disease.

Tested (1) the hypothesis that Parkinson's disease (PD), thought to result in disturbed neuronal outflow from the striatum, leads to circumscribed deficits in cognitive functions presumed to be dependent on the functional integrity of the frontal lobes and (2) whether such deficits could account for previously reported memory and visuoperceptual difficulties in PD. 19 nondemented PD patients were demographically matched to 19 normal elderly control Ss. Three categories of tests were given: (1) tests sensitive to frontal system dysfunction, (2) tests of learning and memory, and (3) tests of visuoperceptual and visuoconstructive skills. Nondemented PD patients demonstrated selective deficits on frontal system tasks; tests of learning and memory and of visuoperceptual and visuoconstructive skill were not significantly impaired once performance on the frontal related tasks was statistically covaried. Results are consistent with the striatofrontal outflow model of neuropsychological impairment in nondemented PD patients. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The Misprediction Recovery Cache

In modern processors, deep pipelines couple with superscalar techniques to allow each pipe stage to process multiple instructions. When such a pipe must be flushed and refilled, as when predicted program flow beyond a branch is subsequently recognized as wrong, the temporary performance loss is significant. While modern branch target buffer (BTB) technology makes this flush/refill penalty fairly rare, the penalty that accrues from the remaining branch mispredictions is a serious impediment to even higher processor performance. Advanced mechanisms that can reduce this residual misprediction penalty can be of enormous value in future microprocessor designs. In this paper we describe the design and performance of a promising new mechanism called the Misprediction Recovery Cache (MRC). The key results of our study are. (1) Small, finite sized MRCs (16 to 256 entry) can effectively reduce branch penalty in deeply pipelined processors. (2) Commercial Benchmarks such as the Winstone benchmarks make better use of larger M RCs due to large number of unique branch instructions unlike the predominantly technical SPECint benchmarks. (3) The MRC hit rates increase with increasing BTB prediction accuracy (5-200% depending on MRC size) due to fewer residual mispredictions associated with better prediction. (4) For the processor architecture we studied, the M RC resulted in up to 20% improvement in cpi(cycles per instruction). (5) The incremental performance gain achievable by adding an MRC to a modern CISC processor (which uses a BTB with a two-level predictor) is two to three times of what was achievable by going from a one-level predictor to a two-level predictor.     

Informatics for oncologic preventive screening

The communication between physicians and patients is often deficient. Little time is devoted to it and the patient receives scanty information with a low emotional content. Some features of our medicine can explain this situation. The rationalist and mechanistic biological model, allows to study only those things that can be undertaken with the scientific method. Psychological, social and spiritual aspects are surpassed. It only looks at material aspects of people, limiting the communication. Patients express their symptoms in an emotional way, with multiple beliefs and fears. The physician converts them to a precise, scientific, measurable and rational medical logical type. This language is not understood by patients, generating hesitancy in the communication. The paternalism is based in the power that physicians have over patients. We give knowledge and ask the patient to subordinate and accept our power. The patient loses his moral right to be informed, to ask, to have doubts or to disagree. Our personal communication is almost always formal, unemotional and with no explanations, further limiting communication.