Cancellation of crosstalk-induced jitter

A novel jitter equalization circuit is presented that addresses crosstalk-induced jitter in high-speed serial links. A simple model of electromagnetic coupling demonstrates the generation of crosstalk-induced jitter. The analysis highlights unique aspects of crosstalk-induced jitter that differ from far-end crosstalk. The model is used to predict the crosstalk-induced jitter in 2-PAM and 4-PAM, which is compared to measurement. Furthermore, the model suggests an equalizer that compensates for the data-induced electromagnetic coupling between adjacent links and is suitable for pre- or post-emphasis schemes. The circuits are implemented using 130-nm MOSFETs and operate at 5-10 Gb/s. The results demonstrate reduced deterministic jitter and lower bit-error rate (BER). At 10 Gb/s, the crosstalk-induced jitter equalizer opens the eye at 10/sup -12/ BER from 17 to 45 ps and lowers the rms jitter from 8.7 to 6.3 ps.     

Effects of fibronectin on articular cartilage chondrocyte proteoglycan synthesis and response to insulin-like growth factor-I

CD30 engagement in human lymphoid cells induces pleiotropic cellular responses that affect cellular viability and proliferation, cytokine production, and nuclear factor kappaB (NF-kappaB) nuclear translocation. Studies examining the molecular basis for this pleiotropism thus far have relied on the use of antibodies and cells transfected with CD30L to trigger CD30, two methods of receptor induction that present important limitations: antibodies are not physiological receptor-triggering molecules and CD30L transfectants induce high background intracellular signaling in the cells under study. We have generated and expressed a functional soluble human CD30L molecule (sCD30L/CD8alpha) comprised of the extracellular domain of human CD30L fused to the extracellular domain of the human CD8alpha chain. Immunoprecipitation and Western blot analysis of sCD30L/CD8alpha revealed the existence of at least two forms of sCD30L/CD8alpha, which exhibited molecular sizes consistent with the existence of monomeric and trimeric forms of the molecule. Binding analyses performed using a soluble CD30 fusion protein (sCD30/gamma1) confirmed the ability of sCD30L/CD8alpha to bind to CD30. Functionally, immobilized sCD30L/CD8alpha-induced cell death in the CD30-expressing lines Karpas-299 and HDLM-2 and reduced proliferative levels in Karpas-299; these effects were inhibitable by the addition of sCD30/gamma1. These studies demonstrate the utility of sCD30L/CD8alpha in characterizing the normal function of CD30L and CD30 and indicate the natural ability of soluble forms of CD30L to trimerize.     

Maximum Likelihood Estimation For The 2-Parameter Weibull Distribution Based On Interval-Data

MLE techniques are presented for estimating time-to-failure distributions from interval-data. Interval-data consist of adjacent inspection times that surround an unknown failure time. Censored interval-data bound the unknown failure time with only a lower time. The 2-parameter Weibull distribution is examined as the failure distribution. Parameter estimates from interval-data and from the midpoints of the intervals are compared for 6 shapes of the Weibull distribution. The results from Monte Carlo simulation runs are used to examine the s-bias and S-variability of the parameter estimates.     

Biomechanical disc culture system: feasibility study using rat intervertebral discs

A small-scale biomechanical disc culture system was designed to stimulate intervertebral disc (IVD) 'motion segment' in culture environment with load-controlled compression and combined load (compression+shear). After 7 days of diurnal mechanical loading, cell viability of discs stimulated with static compression load (0.25 MPa) and static combined load (compression (0.25 MPa)+shear (1.5N)) were similar (>90 per cent) to unloaded controls. Mechanically stimulated discs showed decrease in static/dynamic moduli, early stress relaxation, and loss of disc height after 7 days of diurnal loading. Histological data of discs indicated load-induced transformations that were not apparent in controls. The feasibility of studying the mechanobiology of intact IVD as a motion segment was demonstrated. Media conditioning (improve tissue stability in long-term culture) and application of biochemical gene expression assays (differential tissue response to types of mechanical stimulation) are proposed as future improvements. The study suggests that the limitations in studying mechanobiology of IVD pathology in vitro can be overcome and it is possible to understand the physiologically relevant mechanism of IVD pathology.     

Analysis and equalization of data-dependent jitter

Data-dependent jitter limits the bit-error rate (BER) performance of broadband communication systems and aggravates synchronization in phase- and delay-locked loops used for data recovery. A method for calculating the data-dependent jitter in broadband systems from the pulse response is discussed. The impact of jitter on conventional clock and data recovery circuits is studied in the time and frequency domain. The deterministic nature of data-dependent jitter suggests equalization techniques suitable for high-speed circuits. Two equalizer circuit implementations are presented. The first is a SiGe clock and data recovery circuit modified to incorporate a deterministic jitter equalizer. This circuit demonstrates the reduction of jitter in the recovered clock. The second circuit is a MOS implementation of a jitter equalizer with independent control of the rising and falling edge timing. This equalizer demonstrates improvement of the timing margins that achieve 10/sup -12/ BER from 30 to 52 ps at 10 Gb/s.     

Memory span procedures in Alzheimer's disease.

In a working memory framework, the forward memory span involves a subsidiary system that maintains information, and the backward span relies on a central executive system (CES) that allocates processing resources. The authors hypothesized that a measure of the CES derived from the backward span would distinguish Alzheimer's disease (AD) patients (n&≠&?9) from elderly controls without dementia (n&≠&?9), vary as a function of disease severity, and underlie other cognitive disturbances. Memory span procedures were Digit Span Forward and Backward and Visual Memory Span Forward and Backward. Derived CES measures discriminated between groups, predicted dementia severity, and predicted performance on some of the cognitive tasks examined. However, working memory subsidiary systems also appeared to be affected in AD, and some cognitive deficits in AD were independent of working memory disturbances. The visual memory span backward was the best predictor of group and of dementia severity. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Phase and amplitude pre-emphasis techniques for low-power serial links

A novel approach to equalization of high-speed serial links combines both amplitude pre-emphasis to correct for intersymbol interference and phase pre-emphasis to compensate for deterministic jitter, in particular, data-dependent jitter. Phase pre-emphasis augments the performance of low power transmitters in bandwidth-limited channels. The transmitter circuit is implemented in a 90-nm bulk CMOS process and reduces power consumption by pushing CMOS static logic to the output stage, a 4:1 output multiplexer. The received signal jitter over a cable is reduced from 16.15 ps to 10.29 ps with only phase pre-emphasis at the transmitter. The jitter is reduced by 3.6 ps over an FR-4 backplane interconnect. A transmitter without phase pre-emphasis consumes 18 mW of power at 6Gb/s and 600mVpp output swing, a power budget of 3mW/Gb/s, while a transmitter with phase pre-emphasis consumes 24mW, a budget of 4 mW/Gb/s.     

Predicting data-dependent jitter

An analysis for calculating data-dependent jitter (DDJ) in a first-order system is introduced. The predicted DDJ features unique threshold crossing times with self-similar geometry. An approximation for DDJ in second-order systems is described in terms of the damping factor and natural frequency. Higher order responses demonstrate conditions under which unique threshold crossing times do not exist and total jitter is minimized. The DDJ predictions are verified with jitter measurements in a bandwidth-limited amplifier. The predictions for both first and second-order systems anticipate the features of the observed jitter.