Spontaneous output of acetylcholine from rat diaphragm preparations declines after treatment with botulinum toxin

A gas chromatographic spectrometric assay was used to measure tissue and released acetylcholine and choline in diaphragm preparations of rats previously injected with botulinum toxin type A. Botulinum intoxication was found not to alter the acetylcholine content of rat diaphragms in vivo or in fully paralyzed muscles in vitro. This result provides direct support for the hypothesis that botulinum toxin blocks transmitter release without affecting acetylcholine synthesis. However, in diaphragm preparations in vitro, this toxin was found to inhibit not only the evoked release of acetylcholine but also the spontaneous "leakage" of acetylcholine that is measured at rest. Additional experiments were performed to characterize this action of the toxin. The magnitude of the decline in resting acetylcholine output appears to be too large to be accounted for solely by the known effect of botulinum toxin to reduce the frequency of miniature endplate potentials. The mechanism of this action of botulinum toxin remains an enigma.     

Numerical simulation of two-phase flow in deformable porous media: Application to carbon dioxide storage in the subsurface

In this paper, conceptual modeling as well as numerical simulation of two-phase flow in deep, deformable geological formations induced by CO₂ injection are presented. The conceptual approach is based on balance equations for mass, momentum and energy completed by appropriate constitutive relations for the fluid phases as well as the solid matrix. Within the context of the primary effects under consideration, the fluid motion will be expressed by the extended Darcy's law for two phase flow. Additionally, constraint conditions for the partial saturations and the pressure fractions of carbon dioxide and brine are defined. To characterize the stress state in the solid matrix, the effective stress principle is applied. Furthermore, the interaction of fluid and solid phases is illustrated by constitutive models for capillary pressure, porosity and permeability as functions of saturation. Based on this conceptual model, a coupled system of nonlinear differential equations for two-phase flow in a deformable porous matrix (H²M model) is formulated. As the displacement vector acts as primary variable for the solid matrix, multiphase flow is simulated using both pressure/pressure or pressure/saturation formulations. An object-oriented finite element method is used to solve the multi-field problem numerically. The capabilities of the model and the numerical tools to treat complex processes during CO₂ sequestration are demonstrated on three benchmark examples: (1) a 1-D case to investigate the influence of variable fluid properties, (2) 2-D vertical axi-symmetric cross-section to study the interaction between hydraulic and deformation processes, and (3) 3-D to test the stability and computational costs of the H²M model for real applications.     

Influence of disordering by low-temperature neutron irradiation on the superconducting transition temperature of Nb3Sn

The superconducting transition temperatureT _c of a Nb₃Sn diffusion wire has been studied as a function of low-temperature neutron irradiation (T=10 K).T _c is observed to be essentially constant until the fast neutron dose t (for neutron energiesE>0.1 MeV) exceeds a value of 10¹⁸ n/cm²; after this valueT _c decreases linearly with t up to the maximum applied dose of 1.05×10¹⁹ n/cm². Comparison with theory and other experimental data indicates that radiation-induced disorder is the primary mechanism for the observedT _c changes.Work supported by the Bundesministerium für Forschung und Technologie and by the Deutsche Forschungsgemeinschaft.     

Dream patterns in Anglo and Chicano young adults

This study is the conclusion of an exploratory cross-cultural investigation of dream content and organization. Following our report in "Ego Modalities in the Manifest Dreams of Male and Female Chicanos," (Brenneis and Roll, 1975), this paper examines differences in the organization and content of dreams: (1) between Anglo men and women; (2) between Anglo and Chicano men and Anglo and Chicano women; and (3) between Anglos and Chicanos.     

Preparation and Luminescent Properties of Eu^3＋ Doped Calcium Phosphate Nanocrystalline

The nanocrystalline Eu^3＋ doped calcium phosphate was prepared by calcining precursors, which were got by precipitation method combined with ultrasound treatment and some polysaccharide. The existence of Eu^3＋ inhibited the reaction of Na^＋ ion and SO4^2- radical with apatite and resulted in the transformation of HAP to β- TCP by replacing the calcium ions. The strongest excitation peak was at 393 nm, and other lower peaks were at 361 nm, 375 nm, 381 nm, 418nm. The strongest emission spectrum appeared at about 618nm. The emission peak （579 nm） showed that Eu^3＋ ions distributed on Ca^2＋ sites of the apatitic structure.     

Regret and quality of life across the adult life span: The influence of disengagement and available future goals.

Two studies examined the associations between life regrets and indicators of quality of life across the adult life span. Given that opportunities to undo regrets decline with age, regret intensity was expected to be inversely associated with subjective well-being and health among older adults. In addition, the research explored protective factors that have the potential to reduce older adults' regret intensity. It was suggested that being disengaged from undoing the consequences of regrets and having many future goals available may reduce older adults' intensity of regret and thereby contribute to a better quality of life. Across both studies, the findings demonstrate that older adults perceived reduced opportunities to undo the consequences of their regrets and that regret intensity predicted a reduced quality of life only among older adults. Furthermore, the findings support the adaptive value of disengagement and available future goals for managing life regrets in older adults. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Interpreting the Good Life: Growth Memories in the Lives of Mature, Happy People.

In 2 studies, the authors examined autobiographical memories for the presence of 2 growth orientations that were expected to correspond differentially to maturity and well-being, which are considered to be key facets of "the good life" by L. A. King (2001). Mature participants emphasized integrative memories (conceptual integration and learning), whereas happy participants emphasized intrinsic memories (humanistic concerns). Both kinds of growth memories correlated more strongly with eudaimonic than with hedonic measures of well-being. Growth memories were largely independent of Big Five traits in relation to maturity and well-being. Finally, older participants were more likely than younger participants to have greater maturity (marginally) and well-being, but this was in part explained by older participants' greater tendency to have growth memories. The discussion considers the role of growth memories in the intentional cultivation of the good life. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Growing a hypercubical output space in a self-organizing featuremap

Neural maps project data from an input space onto a neuron position in a (often lower dimensional) output space grid in a neighborhood preserving way, with neighboring neurons in the output space responding to neighboring data points in the input space. A map-learning algorithm can achieve an optimal neighborhood preservation only, if the output space topology roughly matches the effective structure of the data in the input space. We here present a growth algorithm, called the GSOM or growing self-organizing map, which enhances a widespread map self-organization process, Kohonen's self-organizing feature map (SOFM), by an adaptation of the output space grid during learning. The GSOM restricts the output space structure to the shape of a general hypercubical shape, with the overall dimensionality of the grid and its extensions along the different directions being subject of the adaptation. This constraint meets the demands of many larger information processing systems, of which the neural map can be a part. We apply our GSOM-algorithm to three examples, two of which involve real world data. Using recently developed methods for measuring the degree of neighborhood preservation in neural maps, we find the GSOM-algorithm to produce maps which preserve neighborhoods in a nearly optimal fashion.     

A layered adaptive verification platform for simulation, test, and emulation

This adaptive architecture for structuring testbenches accommodates various models of a design, from transaction to silicon. Moreover, the adapter-based architecture supports the execution of design models on different simulators (high level, RTL, gate level, and switch level), hardware emulators (the testbench runs entirely on the emulator), and even testers. Here, we present a modular, layered testbench (MLTB) approach to building a testbench. This approach is similar to platform-based design. It consists of a generic testbench kernel (TBK), connected through a bus to testbench elements. Our verification platform also satisfies another meaning of platform: a set of connected tools or a powerful tool environment, normally with an attached database, that acts as a platform for verification.     

Charged cellular polymers with "ferroelectretic" behavior

Cellular space-charge electrets have recently emerged as a new class of materials for electromechanical devices, offering chances for a wide range of applications and challenges for materials optimization. However, many fundamental and applied aspects of the physics of these novel materials are not yet explored. Here we summarize our present understanding of the (quasi)-piezo- and -pyroelectricity in such materials. In contrast to the dipole-density piezoelectricity in ferroelectric polymers, the piezoelectric-like response of cellular polymers is intrinsic, with positive d/sub 33/ and negative d/sub 31/ and d/sub 32/ piezoelectric-like coefficients. Similarities with ferroelectric materials are outlined, especially switching of "polarization" and (quasi)-piezoelectricity. First steps towards patterned charging of cellular polymers are reported, an immediate consequence of the possibility for "polarization"-switchingin cellular materials. The results on cellular space-charge electrets suggest that well-known electret devices like microphones may be seen in a new light. Examples include dielectric and electromechanical hysteresis loops obtained with a commercially available electret microphone. In view of the results, cellular polymers may henceforth be called "ferroelectrets" and their material behavior "ferroelectretic". From an applied point of view, the performance of a Fresnel zone plate for focussing ultrasound is shown. Such a device may pave the way for a simple tool in nondestructive materials inspection, and demonstrates the large potential of cellular polymers for applications.