Spiperone: influence of spiro ring substituents on 5-HT2A serotonin receptor binding

Spiperone (1) is a widely used pharmacological tool that acts as a potent dopamine D2, serotonin 5-HT1A, and serotonin 5-HT2A antagonist. Although spiperone also binds at 5-HT2C receptors, it is one of the very few agents that display some (ca. 1000-fold) binding selectivity for 5-HT2A versus 5-HT2C receptors and, hence, might serve as a useful template for the development of novel 5-HT2A antagonists if the impact of its various substituent groups on binding was known. In the present investigation we focused on the 1, 3,8-triazaspiro[4.5]decanone portion of spiperone and found that replacement of the N1-phenyl group with a methyl group only slightly decreased affinity for cloned rat 5-HT2A receptors. However, N1-methyl derivatives displayed significantly reduced affinity for 5-HT1A, 5-HT2C, and dopamine D2 receptors. Several representative examples were shown to behave as 5-HT2 antagonists. As such, N1-alkyl analogues of spiperone may afford entry into a novel series of 5-HT2A-selective antagonists.     

Improved genetic algorithm inspired by biological evolution

The process of mutation has been studied extensively in the field of biology and it has been shown that it is one of the major factors that aid the process of evolution. Inspired by this a novel genetic algorithm (GA) is presented here. Various mutation operators such as small mutation, gene mutation and chromosome mutation have been applied in this genetic algorithm. In order to facilitate the implementation of the above-mentioned mutation operators a modified way of representing the variables has been presented. It resembles the way genetic information is coded in living beings. Different mutation operators pose a challenge as regards the determination of the optimal rate of mutation. This problem is overcome by using adaptive mutation operators. The main purpose behind this approach was to improve the efficiency of GAs and to find widely distributed Pareto-optimal solutions. This algorithm was tested on some benchmark test functions and compared with other GAs. It was observed that the introduction of these mutations do improve the genetic algorithms in terms of convergence and the quality of the solutions.     

Material-induced shunts in multicrystalline silicon solar cells

By applying lock-in thermography imaging, light-beam-induced current imaging, electron-beam-induced current imaging at different stages of sample preparation, and infrared light microscopy in transmission mode, the physical nature of the dominant material-induced shunts in multicrystalline solar cells made from p-type silicon material has been investigated. It turns out that these shunts are due to silicon carbide (SiC) filaments, which grow preferentially in grain boundaries and cross the whole cell. These filaments are highly n-type doped, like the emitter layer on the surface of the cells. They are electrically connected both with the emitter and with the back contact, thereby producing internal shunts in the solar cell. The text was submitted by the authors in English.     

TiO2 nanotubes: Self-organized electrochemical formation, properties and applications

The present paper gives an overview and review on self-organized TiO₂ nanotube layers and other transition metal oxide tubular structures grown by controlled anodic oxidation of a metal substrate. We describe mechanistic aspects of the tube growth and discuss the electrochemical conditions that need to be fulfilled in order to synthesize these layers. Key properties of these highly ordered, high aspect ratio tubular layers are discussed. In the past few years, a wide range of functional applications of the layers have been explored ranging from photocatalysis, solar energy conversion, electrochromic effects over using the material as a template or catalyst support to applications in the biomedical field. A comprehensive view on state of the art is provided.     

Half-Integer Flux Quantization in a Superconducting Loop with a Ferromagnetic π-Junction

Superconducting loops containing a π-junction are predicted to show a spontaneous magnetic moment in zero external magnetic field. In order to confirm this longstanding prediction experimentally, we performed magnetization measurements on individual mesoscopic superconducting niobium loops with a ferromagnetic (PdNi) π-junction. The loops are prepared on top of the active area of a micro Hall-sensor based on high mobility GaAs/AlGaAs heterostructures. We observe switching of the loop between different magnetization states at very low-magnetic fields, which is asymmetric for positive and negative sweep direction. This is evidence for a spontaneous current induced by the intrinsic phase shift of the π-junction. In addition, the presence of the spontaneous current at zero applied field is directly revealed by an increase of the magnetic moment with decreasing temperature, which results in a half integer flux quantization in the loop at low temperatures. This work is dedicated to H. von L?hneysen on the occasion of his 60th birthday.     

Ultrastructure of collagen thermally denatured by microsecond domain pulsed carbon dioxide laser

BACKGROUND: Clinical improvement in photodamaged skin after carbon dioxide (CO2) laser resurfacing is thought to result in part from thermal collagen shrinkage. The presence of such collagen has not been unequivocally demonstrated. To identify and characterize the morphological features of collagen after CO2 laser exposure, we irradiated ex vivo human facial skin and bovine calcaneus tendon with microsecond domain pulsed CO2 laser energy and examined specimens for histopathological and ultrastructural changes in collagen. OBSERVATIONS: In dermis and tendon, 3 zones of collagen structure were apparent on electron microscopy. The first, most superficial zone demonstrated loss of collagen structure. The second zone consisted of admixed normal collagen fibers and thickened collagen fibers. Zone 3 consisted of normal-appearing collagen fibers. CONCLUSIONS: Ultrastructural examination of irradiated collagen revealed distinct morphological zones of denatured collagen fibers. Partially denatured fibers had an increased diameter consistent with lineal shrinkage. Zonal distinction was undetectable by light microscopy. Ultrastructurally, the zones of denatured collagen located above the normal fibers correlated with the zone of altered material seen on light microscopy. These findings suggest that collagen fiber shrinkage does occur after pulsed CO2 laser irradiation and that this phenomenon contributed, at least in part, to the immediate tissue contraction observed clinically.     

Laser Assisted Uvulopalatoplasty: an objective evaluation of the technique and results

The indications for conservative and surgical management of fractures of the thoracolumbar spine are reviewed, based upon the morphology of the lesions, which is assessed by meticulous analysis of radiographs, CT scan and in some cases MRI. The author advocates using the AO classification, which considers several subtypes of fractures: compression fractures, distraction fractures and fractures with multidirectional displacement. The indication for treatment is based upon morphological analysis of the lesions, while other factors such as the general condition of the patient or the locally available surgical environment must also be taken into consideration. Up to 50% of thoracolumbar fractures can benefit from surgical management, with posterior or anterior stabilisation, the latter performed through thorascoscopy in selected cases.     

Polymere für Anwendungen in der integrierten Optik — ein Überblick mit ausgewählten Beispielen

Within this paper the development of special polymers for their use in integrated optics is shown exemplarily for selected optical devices (thermooptical switches and arrayed waveguide gratings). Emphasis is put on long-range data transfer in a wavelength region around 1,550 µm. Fluorinated polyacrylates, polycyanurates and triazine-containing reactive polymers were investigated.