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71.
Jan De Cock Stijn Notebaert Kenneth Vermeirsch Peter Lambert Rik Van de Walle 《Multimedia Systems》2010,16(2):139-149
In this paper, we examine spatial resolution downscaling transcoding for H.264/AVC video coding. A number of advanced coding
tools limit the applicability of techniques, which were developed for previous video coding standards. We present a spatial
resolution reduction transcoding architecture for H.264/AVC, which extends open-loop transcoding with a low-complexity compensation
technique in the reduced-resolution domain. The proposed architecture tackles the problems in H.264/AVC and avoids visual
artifacts in the transcoded sequence, while keeping complexity significantly lower than more traditional cascaded decoder–encoder
architectures. The refinement step of the proposed architecture can be used to further improve rate-distortion performance,
at the cost of additional complexity. In this way, a dynamic-complexity transcoder is rendered possible. We present a thorough
investigation of the problems related to motion and residual data mapping, leading to a transcoding solution resulting in
fully compliant reduced-size H.264/AVC bitstreams. 相似文献
72.
Camila I. Irion Monique Williams Jose Condor Capcha Trevor Eisenberg Guerline Lambert Lauro M. Takeuchi Grace Seo Keyvan Yousefi Rosemeire Kanashiro-Takeuchi Keith A. Webster Karen C. Young Joshua M. Hare Lina A. Shehadeh 《International journal of molecular sciences》2022,23(12)
Alport syndrome (AS) is a hereditary renal disorder with no etiological therapy. In the preclinical Col4a3-/- model of AS, disease progression and severity vary depending on mouse strain. The sodium-glucose cotransporter 2 (SGLT2) is emerging as an attractive therapeutic target in cardiac/renal pathologies, but its application to AS remains untested. This study investigates cardiorespiratory function and SGLT2 renal expression in Col4a3-/- mice from three different genetic backgrounds, 129x1/SvJ, C57Bl/6 and Balb/C. male Col4a3-/- 129x1/SvJ mice displayed alterations consistent with heart failure with preserved ejection fraction (HFpEF). Female, but not male, C57Bl/6 and Balb/C Col4a3-/- mice exhibited mild changes in systolic and diastolic function of the heart by echocardiography. Male C57Bl/6 Col4a3-/- mice presented systolic dysfunction by invasive hemodynamic analysis. All strains except Balb/C males demonstrated alterations in respiratory function. SGLT2 expression was significantly increased in AS compared to WT mice from all strains. However, cardiorespiratory abnormalities and SGLT2 over-expression were significantly less in AS Balb/C mice compared to the other two strains. Systolic blood pressure was significantly elevated only in mutant 129x1/SvJ mice. The results provide further evidence for strain-dependent cardiorespiratory and hypertensive phenotype variations in mouse AS models, corroborated by renal SGLT2 expression, and support ongoing initiatives to develop SGLT2 inhibitors for the treatment of AS. 相似文献
73.
Miles Lambert 《Costume》2014,48(1):46-59
Specific clothing bequests form a distinct and often intimate feature in a range of English wills during the seventeenth and eighteenth centuries. Carefully and symbolically allocated to new owners, garments were thus imbued with commemoration as well as financial worth. This paper suggests that gender differentials in this practice have been exaggerated as individual men could be as committed to the process as their female counterparts. Crucially, men and women without children or partners were most disposed to draw up detailed wills reallocating a range of possessions, especially clothing. In this creation of stewardship for chosen garments, individual personality and familial situation were more decisive than any general social or economic considerations. 相似文献
74.
Aykut Avci Jan De CockPeter Lambert Roel BeernaertJelle De Smet Lawrence BogaertYouri Meuret Hugo ThienpontHerbert De Smet 《Journal of Visual Communication and Image Representation》2012,23(2):287-292
An efficient disparity estimation algorithm for multi-view video sequences, recorded by a two-dimensional camera array in which the cameras are spaced equidistantly, is presented. Because of the strong geometrical relationship among views, the disparity vectors of a certain view can for most blocks be derived from the disparity vectors of other views. A frame constructed using that idea is called a D frame in this work. Three new prediction schemes which contain D frames are proposed for encoding 5 × 3 multi-view video sequences. The schemes are applied to several multi-view image sequences taken from a camera-array and they are compared in terms of quality, bit-rate and complexity. The experimental results show that the proposed prediction schemes significantly decrease the complexity of the encoder at a very low cost of quality and/or bit-rate. 相似文献
75.
Grouped data occur frequently in practice, either because of limited resolution of instruments, or because data have been summarized in relatively wide bins. A combination of the composite link model with roughness penalties is proposed to estimate smooth densities from such data in a Bayesian framework. A simulation study is used to evaluate the performances of the strategy in the estimation of a density, of its quantiles and first moments. Two illustrations are presented: the first one involves grouped data of lead concentration in the blood and the second one the number of deaths due to tuberculosis in The Netherlands in wide age classes. 相似文献
76.
Few versatile software programs allowing for the precise simulation of drying processes in a whole industrial plant are available. This work was done during the creation of a generic convective drying simulator for food solid particle in ProSimPlus, a chemical engineering software. Modeling approaches are discussed, and among them a compromise between first-principle modeling, reduced lab work, ability to accurately predict kinetics for a wide range of drying conditions, and low simulation time is presented. Predictive models of some required food product properties are examined. Two toolboxes were created: one estimating physical properties of foodstuffs and another simulating transfers in air and in the product. This approach is validated on four food products (with various formulations and shapes). 相似文献
77.
Elodie Belnoue Alexis Vogelzang Natalie E. Nieuwenhuizen Magdalena A. Krzyzaniak Stephanie Darbre Mario Kreutzfeldt Ingrid Wagner Doron Merkler Paul-Henri Lambert Stefan H. E. Kaufmann Claire-Anne Siegrist Daniel D. Pinschewer 《International journal of molecular sciences》2022,23(5)
Mycobacterium tuberculosis (Mtb) represents a major burden to global health, and refined vaccines are needed. Replication-deficient lymphocytic choriomeningitis virus (rLCMV)-based vaccine vectors against cytomegalovirus have proven safe for human use and elicited robust T cell responses in a large proportion of vaccine recipients. Here, we developed an rLCMV vaccine expressing the Mtb antigens TB10.4 and Ag85B. In mice, rLCMV elicited high frequencies of polyfunctional Mtb-specific CD8 and CD4 T cell responses. CD8 but not CD4 T cells were efficiently boosted upon vector re-vaccination. High-frequency responses were also observed in neonatally vaccinated mice, and co-administration of rLCMV with Expanded Program of Immunization (EPI) vaccines did not result in substantial reciprocal interference. Importantly, rLCMV immunization significantly reduced the lung Mtb burden upon aerosol challenge, resulting in improved lung ventilation. Protection was associated with increased CD8 T cell recruitment but reduced CD4 T cell infiltration upon Mtb challenge. When combining rLCMV with BCG vaccination in a heterologous prime-boost regimen, responses to the rLCMV-encoded Mtb antigens were further augmented, but protection was not significantly different from rLCMV or BCG vaccination alone. This work suggests that rLCMV may show utility for neonatal and/or adult vaccination efforts against pulmonary tuberculosis. 相似文献
78.
Felix Amissah Shalina Taylor Randolph Duverna Lambert T. Ayuk‐Takem Nazarius S. Lamango 《European Journal of Lipid Science and Technology》2011,113(11):1321-1331
Polyisoprenylation is a set of secondary modifications involving proteins whose aberrant activities are implicated in cancers and degenerative disorders. The last step of the pathway involves an ester‐forming polyisoprenylated protein methyl transferase‐ and hydrolytic polyisoprenylated methylated protein methyl esterase (PMPMEase)‐catalyzed reactions. Omega‐3 and omega‐6 PUFAs have been linked with antitumorigeneis and tumorigenesis, respectively. PUFAs are structurally similar to the polyisoprenyl groups and may interfere with polyisoprenylated protein metabolism. It was hypothesized that PUFAs may be more potent inhibitors of PMPMEase than their more polar oxidative metabolites, the prostaglandins. As such, the relative effects of PUFAs and prostaglandins on PMPMEase could explain the association between cyclooxygenase‐2 (COX‐2) expression in tumors, the chemopreventive effects of the non‐steroidal anti‐inflammatory (NSAIDs) COX‐2 inhibitors and PUFAs. PUFAs such as AA, EPA, and DHA inhibited PMPMEase activity with Ki values of 0.12–3.7 µM. The most potent prostaglandin was 63‐fold less potent than AA. The PUFAs were also more effective at inducing neuroblastoma cell death at physiologically equivalent concentrations. The lost PMPMEase activity in AA‐treated degenerating cells was restored by incubating the lysates with COX‐1 or COX‐2. PUFAs may thus be physiological regulators of cell growth and could owe these effects to PMPMEase inhibition. Practical applications: Some PUFAs have been widely reported to have anticancer benefits. However, the molecular mechanisms for these effects are not well understood. The findings in the current paper appear to suggest that inhibition of PMPMEase may underlie their effects. They also imply that the expression of COX‐2 in various tumors may serve to convert the PUFAs into significantly less inhibitory prostaglandins. From these findings, AA and the other PUFAs, rather than being substrates for the synthesis of tumorigenic agents may actually contribute in suppressing cell proliferation. This being congruent with the lower cancer risks associated with long term use of anti‐inflammatory agents, the practical implications will likely include the nutritional and/or therapeutic management of cancer with the goal of maintaining suitable levels of the fatty acids in tissues. 相似文献
79.
Johan Plomp Mikko Heiskanen Mika Hillukkala Tapio Heikkilä Jari Rehu Niek Lambert Victor van Acht Tom Ahola 《International Journal of Wireless Information Networks》2011,18(4):280-294
In this paper, we highlight considerations for synchronization issues in body area networks. Requirements for the synchronization
accuracy in body area networks depend on the application at hand. Synchronization may be needed for power management, sample
ordering, calculation of stimulus responses and for sensor fusion. This paper provides a theoretical exercise to help understand
the accuracy required for typical human motion sensing. It gives an overview of various synchronisation strategies used and
implemented in prototype systems. Lessons learnt from practical implementations using Bluetooth, an IEEE 802.15.4 proprietary
network and Nanonet are presented to illustrate the principles involved. The discussion provides some considerations and the
requirements for typical WBAN applications. 相似文献
80.