The formation and evolution of the Society of Nuclear Medicine

The Society of Nuclear Medicine was created and constructed by persons from many branches of medicine and the physical sciences, but it originated mostly in the mind of a chemist-physicist-engineer named Norman "Jeff" Holter. Because most medical organizations seemed to care little about the use of radioactive materials for medical purposes, Holter believed a new organization was necessary for their promotion. From its origin in 1954 as the Pacific Northwest Society of Nuclear Medicine, The Society of Nuclear Medicine became a national, multidisciplinary organization in 1956. Rapidly gathering strength with an expanding membership, it employed an administrator in 1959. With this administrator and a dedicated volunteer editor, publication of the Journal of Nuclear Medicine began. Over the next several years the Society evolved into an active force in the development of the application of radioactivity to medical applications. It generated significant internal initiatives and participated in the generation of several important external institutions. The Society of Nuclear Medicine developed a tradition of annual meetings with strong educational programs for all members. By nurturing and embracing the Technologist Section, the Society became a robust and representative organization for all who serve nuclear medicine. From these beginnings came the vigorous Society of Nuclear Medicine of today. Jeff Holter (1914-1983) would be justifiably proud.     

Spatial gamut mapping algorithms for cross‐display color reproduction

Abstract— Owing to the fast developments of computer networks and color imaging technologies, there is a tendency towards remote proofing in the printing or textile industries. More cases such as cross‐display color matching will occur in the future information society. The problems of color mismatching we usually find in cross‐display devices have been widely discussed today. In this paper, to achieve equivalent color matching between a sRGB monitor and an Adobe RGB monitor, the spatial gamut mapping algorithm (SGMA), which introduces sigmoidal tone mapping, multi‐mapping paths, and unsharp mask (USM) operation into a sRGB color‐management system, is proposed. According to the designs of USM locations, this proposed SGMA can be further developed into pre‐USM, post‐USM, and double‐USM types. Besides, two critical image characteristics, edge map and color histogram, are investigated to establish the relationship between image content and SGMA. The psychophysical experimental results show that double‐USM SGMA obtains better color matching than the other spatial types.     

The influence of collaboration styles to children’s cognitive performance in digital problem-solving game “William Adventure”: A comparative case study

Since a large variety of digital games have been used in many fields for educational purposes, their real functions in learning have caught much attention as well. This study first defines learning characteristics of problem-solving digital games and their corresponding cognitive levels, then designs and develops a problem-solving game in accordance to the criteria. Tasks in the game context are inter-related to each other so that players need to critically and creatively think about problem solutions. Learners’ task analyses are performed to observe four elementary learners’ gaming paths, behaviors and cognitive activities, individually and collaboratively. System documentation, video recording, researcher observation, and interviews are conducted to analyze learners’ learning strategies and their cognitive performance during the gaming process.     

Implementation of a robust complex extended Kalman filter with LabVIEW for detection in a distorted signal

This article proposes the PC-based LabVIEW as the software to develop the algorithm of the robust complex extended Kalman filter (RCEKF) to detect the parameters of the voltage signal in power systems. The hardware used is a sample-and-hold card and a data acquisition (DAQ) card to extract the data from an outside system to the PC, and the program will compute the amplitude, frequency, and phase of the voltage signal with RCEKF. To validate the performance of RCEKF, the voltage signal from a function generator was applied to check the feasibility of the algorithm. This application was also used in the Taiwan Power Company (TPC) secondary substation in Sijhou, Taiwan.     

Product structure (BOM)-based product similarity measures using orthogonal procrustes approach

In geometry, two configurations are called similar if they can be brought to a complete match by rigid motions and dilations. In the simplest case, product designs X and Y have the same dimensionality and same number of points which can be brought into a one to one correspondence by substantive considerations. Under orthogonal transformations, product design Y can only be rotated and reflected in order to approximate product design X. As for the “as close as possible” or “relatively close” criterion, a reasonable definition would be to measure the distances between corresponding points, square these values, and add them to obtain the sum-of-squares criterion L. In this paper, a product structure (BOM)-based product similarity measures using orthogonal procrustes approach is proposed. A structural product is first transformed into bill of materials (BOM), the structural similarity measurement between a product query and target product is calculated and evaluated using orthogonal procrustes approach. The results show that the proposed product structure similarity measure method can help companies find desired product information based on BOM feature.     

Label-free Growth Receptor-2 Detection and Dissociation Constant Assessment in Diluted Human Serum Using a Longitudinal Extension Mode of a Piezoelectric Microcantilever Sensor

We have investigated real-time, label-free, in-situ detection of human epidermal growth factor receptor 2 (Her2) in diluted serum using the first longitudinal extension mode of a lead zirconate-lead titanate (PZT)/glass piezoelectric microcantilever sensor (PEMS) with H3 single-chain variable fragment (scFv) immobilized on the 3-mercaptopropyltrimethoxysilane (MPS) insulation layer of the PEMS surface. We showed that with the longitudinal extension mode, the PZT/glass PEMS consisting of a 1 mm long and 127 μm thick PZT layer bonded with a 75 μm thick glass layer with a 1.8 mm long glass tip could detect Her2 at a concentration of 6-60 ng/ml (or 0.06-0.6 nM) in diluted human serum, about 100 times lower than the concentration limit obtained using the lower-frequency flexural mode of a similar PZT/glass PEMS. We further showed that with the longitudinal mode, the PZT/glass PEMS determined the equilibrium H3-Her2 dissociation constant K(d) to be 3.3±0.3 × 10(-8) M consistent with the value, 3.2±0.28 ×10(-8) M deduced by the surface plasmon resonance method (BIAcore).     

Coherency Hub Design for Multisocket Sun Servers with CoolThreads Technology

CoHub, a coherency hub ASIC, provides a cost-effective way to extend a glueless two-node chip-multithreading system to a four-node system without changes to the processor. The four-node, 256-thread system achieves near-linear scaling of performance with thread count on transaction-processing workloads. Time-to-market pressure, 800-MHz operation, and a six-stage pipeline were among the constraints that shaped CoHub's design.     

Weaknesses and improvements of the Yoon–Ryu–Yoo remote user authentication scheme using smart cards

Remote user authentication scheme is a procedure which allows a server to authenticate a remote user through insecure channel. Recently, Yoon, Ryu and Yoo made an enhancement based on Ku–Chen’s remote user authentication scheme by using smart cards. The scheme has the merits of providing mutual authentication, no verification table, freely choosing password, involving only few hashing operations and parallel session attack resistance. In this paper, we point out security flaws of Yoon–Ryu–Yoo’s protocols against masquerading attack, off-line password guessing attacks and parallel session attack. An improvement to enhance Yoon–Ryu–Yoo’s security scheme is proposed.     

A graph-theoretic model for optimizing queries involving methods

Traditional algorithms for optimizing the execution order of joins are no more valid when selections and projections involve methods and become very expensive operations. Selections and projections could be even more costly than joins such that they are pulled above joins, rather than pushed down in a query tree. In this paper, we take a fundamental look at how to approach query optimization from a top-down design perspective, rather than trying to force one model to fit into another. We present a graph model which is designed to characterize execution plans. Each edge and each vertex of the graph is assigned a weight to model execution plans. We also design algorithms that use these weights to optimize the execution order of operations. A cost model of these algorithms is developed. Experiments are conducted on the basis of this cost model. The results show that our algorithms are superior to similar work proposed in the literature. Received 20 April 1999 / Accepted 9 August 2000 Published online 20 April 2001     

Synthesis of bio-functionalized copolymer particles bearing carboxyl groups via a microfluidic device

Monodisperse copolymer particles carrying surface carboxyl groups in the range of 50–200 μm were prepared by in situ UV polymerization of ethyleneglycol dimethacrylate (EGDMA) with acrylic acid (AA) via a microfluidic flow-focusing device (MFFD). The design of the coaxial orifices in the MFFD enables the confinement of the comonomer liquid thread to the central axis of the microchannel, which can avoid the wetting problem of comonomer liquid with the microchannel and can successfully produce monodisperse copolymer microspheres with coefficient of variance below 5%. The effects of concentration of EGDMA and AA on droplet diameters and the distribution of carboxyl group on particle surfaces were examined. It has been found that, increasing the concentration of AA would decrease particle sizes, but increase the distribution of carboxyl group on particle surfaces. Bioconjugation of the carboxylated copolymer particles with the anti-rabbit IgG–Cy3 conjugates was successfully demonstrated. By increasing the concentration of AA accompanied with decreasing the particle sizes, high efficiency of bioconjugation on carboxylated copolymer particles was achieved. The rapid continuous synthesis of carboxylated copolymer particles via a microfluidic device provides a reliable control of particle sizes and composition for massive production in biotechnological applications.