Calculation of the stress intensity factor for arbitrary finite cracked body by using the boundary weight function method

The state of thermal stresses for a periodic two-layered elastic space weakened by an interface thermally insulated Griffith crack and loaded by concentrated line heat sources is investigated. The analysis is performed within the framework of the homogenized model with microlocal parameters. The stress intensity factors at the crack tips are determined. Two examples of the application of the results obtained are detailed.     

GaAs-GaAlAs heterostructure single-mode channel-waveguide cutoff modulator and modulator array

A GaAs single-mode channel-waveguide cutoff modulator that utilizes a GaAs-GaAlAs heterostructure and a linear array of such modulators are reported for the first time. We have measured a cutoff voltage as low as 9.0 V and an extinction ratio greater than 20 dB at an optical wavelength of 1.3 μm in a basic modulator that utilized a GaAs-Ga0.93Al0.07As heterostructure with a 0.9 μm thick GaAs epitaxial layer together with a ridge channel 2.5 mm in length and 5.0 μm in width. We have also succeeded in the realization of a high packing density (500 channels/cm) linear array of such cutoff modulators in the same GaAs substrate with equally satisfactory results. An RF bandwidth of 2.5 GHz has also been measured with the elementary modulator of such array. As in the case for LiNbO3substrates, the GaAs-based integrated optic modules that result from integration of such cutoff modulator arrays, microlens arrays, and planar acoustooptic or electrooptic Bragg diffraction grating arrays in a common substrate may be used to perform multiport switching, computing, and RF signal processing.     

Cell cycle regulation of the Saccharomyces cerevisiae polo-like kinase cdc5p

Progression through and completion of mitosis require the actions of the evolutionarily conserved Polo kinase. We have determined that the levels of Cdc5p, a Saccharomyces cerevisiae member of the Polo family of mitotic kinases, are cell cycle regulated. Cdc5p accumulates in the nuclei of G2/M-phase cells, and its levels decline dramatically as cells progress through anaphase and begin telophase. We report that Cdc5p levels are sensitive to mutations in key components of the anaphase-promoting complex (APC). We have determined that Cdc5p-associated kinase activity is restricted to G2/M and that this activity is posttranslationally regulated. These results further link the actions of the APC to the completion of mitosis and suggest possible roles for Cdc5p during progression through and completion of mitosis.     

A new process of fabricating inverted-staggered tri-layer thin-filmtransistors

A new method of fabricating a-Si:H TFT with etching-stop structure has been proposed. Only one plasma-enhanced chemical vapor deposition is required in this new method and a PH₃/H₂ plasma treatment during the deposition has been used to form the TFT contact and thus saved another plasma deposition. With this method, a TFT of 500 Å active layer has been fabricated successfully. The drain current and saturation mobility of this device is 2.4×10^-7 A and 0.1 cm²/V sec, respectively, which is comparable to the conventional fabricating method. The plasma treatment will also form an additional leakage path on the TFT top surface and increase the TFT subthreshold slope. However, a current of less than 1 pA at V_G=-2.4 V can still be obtained. The possible mechanism of the contact formation by the plasma treatment is also discussed     

Advances in software engineering

Software is the key technology in applications as diverse as accounting, hospital management, aviation, and nuclear power. Application advances in different domains such as these-each with different requirements-have propelled software development from small batch programs to large, real-time programs with multimedia capabilities. To cope, software's enabling technologies have undergone tremendous improvement in hardware, communications, operating systems, compilers, databases, programming languages, and user interfaces, among others. In turn, those improvements have fueled even more advanced applications. Improvements in VLSI technology and multimedia, for example, have resulted in faster, more compact computers that significantly widened the range of software applications. Database and user interface enhancements, on the other hand, have spawned more interactive and collaborative development environments. Such changes have a ripple effect on software development processes as well as on software techniques and tools. In this article, we highlight software development's crucial methods and techniques of the past 30 years     

Antiretroviral drugs as a public health intervention for pregnant HIV-infected women in rural South Africa: an issue of cost-effectiveness and capacity

OBJECTIVE: To estimate cost-effectiveness and capacity requirements for providing antiretroviral drugs to pregnant HIV-infected women in rural South Africa. SETTING: Hlabisa health district, where HIV prevalence among pregnant women was 26.0% in 1997. METHODS: Calculation of the number of paediatric HIV infections averted under three scenarios, and their cost. No intervention was compared with scenario A (zidovudine delivered within current infrastructure), scenario B (zidovudine delivered through enhanced infrastructure), and scenario C (short-course zidovudine plus lamivudine delivered through enhanced infrastructure). Cost-effectiveness was defined as cost per infection averted and cost per potential life-year gained. Capacity was determined in terms of staff and infrastructure required to effectively implement the scenarios. RESULTS: With no intervention, 657 paediatric HIV infections were projected for 1997. In scenario A this could be reduced by 15% at a cost of US$ 574 825, in scenario B by 42% at US$ 1520770, and in scenario C by 47% at US$ 764901. In scenario C, drugs accounted for 76% of costs, whereas additional staff accounted for 18%. Cost per infection averted was US$ 2492 and cost per potential life-year gained (discounted at 3%) was US$ 88. Cost of scenario C was equivalent to 14% of the 1997 district health budget. At least 12 extra counsellors and nurses and one laboratory technician, together with substantial logistical and managerial support, would be needed to deliver an effective intervention. CONCLUSION: Although antiretrovirals may be relatively cost-effective in this setting, the budget required is currently unaffordable. Developing the capacity required to deliver the intervention would pose both a major challenge, and an opportunity, to improve health services.     

Creutzfeldt-Jakob disease: neurophysiologic visual impairments

OBJECTIVE: The predictive value of electrophysiologic visual testing in Creutzfeldt-Jakob disease (CJD) was investigated, and the retinal pathologic findings in three cases are reported. BACKGROUND: The fatal prognosis of CJD, its transmissibility, and the lack of treatment make early diagnosis essential in averting human-to-human transmission. Electroretinogram and visual evoked potentials have been studied in few cases of CJD. METHODS: A visual electrophysiologic examination was performed in 41 consecutive patients referred with suspected CJD. The disease had been diagnosed in 24 patients (CJD group; 15 were confirmed neuropathologically and 9 by clinicolaboratory methods in accordance with diagnostic criteria). The remaining 17 patients were diagnosed with other neurologic disorders, and served as a control group. RESULTS: Flash electroretinogram revealed a significant decrease in the amplitude of the B1 wave (<60 microV) and the B/A ratio (<2) in the CJD group compared with those in the control group. Flash visual evoked potentials revealed no significant difference in latency, but amplitude was increased (>10 microV) in the CJD group, especially in patients with myoclonus. CONCLUSIONS: The visual electrophysiologic abnormalities provide an interesting noninvasive diagnostic tool in idiopathic CJD. The B1-wave decrease is closely correlated with the outer plexiform layer abnormalities observed on neuropathologic examination.     

Activated protein C resistance, thrombophilia, and inflammatory bowel disease

Thromboembolic events frequently complicate the clinical course of patients with inflammatory bowel disease (IBD). Hereditary thrombophilia may contribute to this tendency. Resistance to activated protein C is the most recently described thrombophilic state and may account for up to 40% of patients with thrombophilia. Thirty-seven patients with IBD were studied (mean age 44 years, range 18-82 years). Three patients had a history of thrombotic episodes. The 37 controls included 23 men and 17 women (mean age 48 years, range 16-89 years). Disease activity was assessed using the Harvey Bradshaw index for patients with Crohn's disease and the Truelove and Witts grading system for patients with ulcerative colitis. Levels of fibrinogen, antithrombin III (ATIII), protein C, protein S, activated protein C resistance (APCR), and the presence of a lupus anticoagulant (LA) were determined. Median ATIII levels in patients with IBD were significantly lower than controls (98% vs 106%, P = 0.007), while fibrinogen was elevated (4.2 vs 3.3 g/liter, P = 0.026) despite quiescent disease activity. LA was detected in 7/37 patients in the IBD group compared to 0/37 controls. (chi2 = 5.68, P = 0.017). No significant difference was observed in levels of inherited thrombophilic factors and in particular APCR between IBD patients and controls. In conclusion, the presence of inherited thrombophilic defects, in particular APCR, is uncommon in patients with IBD and does not merit routine screening.