On improving the computational efficiency of digital lightwave linksimulation

Monte Carlo simulation can be used to estimate the bit error rate (BER) in digital lightwave communication links. However, when the link includes an avalanche photodetector (APD) receiver and is operating at a low BER, Monte Carlo simulation requires excessive execution time unless assumptions are made about the APD statistics. Techniques are presented that reduce the computational resources required to estimate the BER for these systems by two orders of magnitude. The speed-up is achieved by developing anew, more efficient random number generation algorithm for APD shot noise and by applying a tail extrapolation technique to the conditional distributions at the sample-and-decide input in the receiver. Receiver thermal noise is handled analytically. Accurate BER estimates for an NRZ direct-detection system are obtained in approximately 1.5 CPU hours on a VAXstation II using a combination of these techniques     

Benzocyclobutene (BCB) dielectrics for the fabrication of high density,thin film multichip modules

A new class of organic dielectrics, benzocyclobutenes, 1, are described and their application to the fabrication of thin film multichip modules is detailed. Key properties for3, a siloxy containing BCB derivative include low dielectric constant (2.7), low loss (0.008 at 1 MHz), low water absorption (0.25% after 24 h water boil) and high degree of planarization (>90% from one layer coverage). All other properties meet the requirements necessary for fabrication of thin film MCM structures.     

Optimization of transmitter and receiver filters for digitalcommunication systems using mean field annealing

A technique for finding transmitter and receiver filters for a wide class of digital communication systems which minimize the bit-error rate (BER) is presented. The technique uses Monte Carlo simulation to estimate the BER and mean field annealing (MFA) to optimize the pulse shapes. Modeling of the link can be as complex as simulation will allow, while MFA is resistant to the statistical variation in the BER estimate from the simulation. Initially, the MFA technique was applied to a binary symmetric channel in a nonsimulation environment, and an approximate analysis of the behavior of MFA for this problem was performed. In a more complex example, MFA was coupled with Monte Carlo simulation techniques to find near-optimal transmit and receive filters for a satellite communications link, taking 6 CPU hours on a DECstation 3100. The BER of the link was found to be as much as three orders of magnitude lower when using the MFA-constructed optimal filters than when using filters from other comparison results. For this example, the pulse shapes obtained using MFA exhibit a low BER even as the parameter controlling the nonlinearity of the satellite-link model is varied over a wide range, thus showing the solution is robust     

Chain reactions linking acorns to gypsy moth outbreaks and Lyme disease risk

In eastern U.S. oak forests, defoliation by gypsy moths and the risk of Lyme disease are determined by interactions among acorns, white-footed mice, moths, deer, and ticks. Experimental removal of mice, which eat moth pupae, demonstrated that moth outbreaks are caused by reductions in mouse density that occur when there are no acorns. Experimental acorn addition increased mouse density. Acorn addition also increased densities of black-legged ticks, evidently by attracting deer, which are key tick hosts. Mice are primarily responsible for infecting ticks with the Lyme disease agent. The results have important implications for predicting and managing forest health and human health.     

An extended panel of hamster-human hybrids for chromosome 2q

A hamster-human hybrid containing only the q arm of chromosome 2 has been used to construct a panel of hybrids bearing reduced regions of chromosome 2 using the technique of irradiation fusion gene transfer. The human chromosome 2 carried the Ecogpt gene and all hybrids were selected using this marker. The integrated Ecogpt gene was localized to the region 2q33-34, resulting in the selective retention of this region in the hybrids. These data were combined with another previously constructed panel of hybrids containing regions of 2q, which were enriched for the region 2q36-37. The combined hybrid panel is useful for the mapping of new markers to defined regions of chromosome 2 and for the cloning of genes located on 2q by a positional strategy.     

Duodenoesophageal reflux induces esophageal adenocarcinoma without exogenous carcinogen

Central nervous system (CNS) disease is a major feature of simian immunodeficiency virus (SIV) infection of macaques. To define the spectrum of CNS lesions in SIV-infected macaques and the potential associations with viral strain and disease course, we performed a retrospective analysis of necropsies on 124 macaques with SIV-induced AIDS. Histologic evidence of CNS disease was observed in 71 (57.3%) of the 124 animals. SIV encephalitis was the most common CNS lesion occurring in 43.7% (31/71) of the animals with CNS disease and 25% of all animals. The incidence of SIVE correlated significantly with shortened survival (P=0.0207). In addition, SIVE was seen in 42.9% (15/35) of rapid progressors (animals that died within 200 days) compared to only 18% (16/89) of normal progressors (animals that lived longer than 200 days) (P=0.011). Animals with SIVE had higher viral loads in peripheral blood than those that did not, but this difference did not reach statistical significance. Similarly, while animals infected with uncloned SIVmac251 had a higher incidence of SIVE (27.5%; 14/51) than animals infected with molecularly cloned SIVmac239 and its T-cell tropic derivatives (18.5%; 10/54) this difference was not statistically significant. In this study rapid disease progression and SIVE were highly correlated making separation of viral determinants of virulence from those of neurovirulence difficult.     

Adrenergic and Cholinergic Nerves of the Human Urethra and Urinary Bladder. A histochemical study

The occurrence and distribution of adrenergic and acetylcholine esterase (AChE) positive nerves in the human urethra and urinary bladder were studied histochemically with the fluorescence method of Falck and Hillarp, and the copper thiocholine method of Koelle and Friedenwald. Both types of nerves were mainly confined to the layers of smooth muscle cells in the walls of the organs. In all parts of the urethra, there was a scanty supply of adrenergic nerves. Few adrenergic nerves were also found in the urinary bladder, except in the trigone area, where they were abundant. AChE-positive nerves were uniformly and richly distributed in the urinary bladder. Throughout the urethra the distribution of AChE-positive nerve fibres was uniform, but the number was clearly less than in the urinary bladder. No intrmurally located adrenergic or AChE-Positive ganglion cells could be demonstrated.     

Evolution of cavity size distributions in dual-ion irradiated austenitic stainless steel and Fe-Cr-Ni ternary alloys

The first four moments of experimentally measured cavity size distributions in dual-ion irradiated 304SS, Fe-12Ni-15Cr and Fe-30Ni-15Cr alloys have been calculated for a range of fluences, helium injection rates, and irradiation temperatures. The moments are shown to correctly describe the effects of alloy composition, fluence, helium and temperature on the evolution of the cavity size distributions. Experimentally determined moments are compared with those calculated from cavity nucleation and growth theories. The moments reflect the competition between nucleation and growth processes and provide insight into the details of the transient low swelling regime.     

MR imaging

MRI is a tool of unprecedented capabilities for evaluating arthritis and its progression. Not only can it non-invasively delineate the anatomy of all components of a joint with unparalleled clarity, MRI is also capable of probing important functional and compositional parameters of disease in these tissues. Particularly intriguing is MRI's potential for identifying very early changes of joint disease when clinical symptoms may be minimal or absent. Early detection of patients who are at risk for developing progressive disease may allow appropriate treatment to be initiated earlier, when there may be a greater chance of favourable outcome. MRI can, furthermore, provide objective and quantitative measures of disease progression and treatment response. Certain parameters, such as articular cartilage volume, have been validated cross-sectionally; however, their longitudinal performance has yet to be established. Further work is, therefore, necessary to thoroughly validate and optimize some of these measures so that they can begin to be used in more powerful ways to explore the pathophysiology and potential therapies of arthritic disorders.