Anatomical structures determining blood flow in the heart left ventricle

The presence of twisted helical flow patterns in the cardiac cavities during ventricular filling and ejection was supposed. This work was intended in order to show that the intra-ventricular trabeculation plays the determining role in such a flow formation and to find some analytical approaches for its analysis. The morphometric study of human left-ventricular and aortic corrosion casts and dynamic measurement of the aorta by MRI-technique were performed. The data were analysed by means of the Mathematica program. Two groups of trabecules were identified that refer to the inlet and outlet of the ventricular blood flow. The first group consists of trabecules of the free left-ventricular wall. The second group consists of long trabecules going along the anterior left-ventricular wall and intracavital lines of the papillary muscles. Both are twisted clockwise and converge in the flow direction. Each group of trabecules is oriented towards the mitral or aortic valve orifices, correspondingly. It was concluded that the helical trabecular organization acts as flow directing paddles that change their mutual orientation during the cardiac cycle evolution. The reorientation of the flow takes place due to sequential contraction of the ventricular structures. The formalization of trabecular orientation will allow one to calculate improved models of implantable substitutes and auxiliary devices for cardio-vascular surgery.Sadly deceased.     

Analysis of right ventricular function during bypass of the left side of the heart by afterload alterations in both normal and failing hearts

This study investigated the mechanism of right ventricular failure during bypass of the left side of the heart by precisely assessing right ventricular function with use of a conductance catheter. Bypass of the left side of the heart was established with a centrifugal pump in 10 mongrel dogs weighing 11 to 19 kg. Right ventricular function during left heart bypass was evaluated by two parameters that were both derived from measurement of relative change in right ventricular volume by the conductance catheter technique. One parameter was the right ventricular end-systolic pressure-volume relationship as a load-independent index, and the other was the peak right ventricular pressure-right ventricular stroke volume relationship as a "force-velocity relationship." These parameters were measured in both normal and failing hearts while afterload was increased by bilateral intrapulmonary balloon inflation. Moreover, changes in these relationships were observed by varying assist ratios of left heart bypass from 0% to 100%. Failing heart models were induced by normothermic aortic clamping for 20 minutes. The right ventricular end-systolic pressure-volume relationship in normal hearts did not change, irrespective of the assist ratio of left heart bypass, whereas that in failing hearts decreased from 4.25 +/- 1.41 mm Hg/ml without bypass of the left side of the heart to 3.53 +/- 1.30 mm Hg/ml after 100% assist of left heart bypass (p < 0.05). In the peak right ventricular pressure-right ventricular stroke volume relationship, right ventricular stroke volume was almost constant in normal hearts when afterload was increased regardless of the assist ratio of left heart bypass. Moreover, right ventricular stroke volume was maintained at a higher level during bypass of the left side of the heart compared with that without left heart bypass. However, that slope of the relationship in failing hearts was inversely linear and became significantly steeper after 100% assist of bypass of the left side of the heart compared with that without left heart bypass (-0.131 +/- 0.042 versus -0.051 +/- 0.038, p < 0.005). Therefore ++these two slopes of the relationship intersected at a point that was considered the critical point of afterload during bypass of the left side of the heart. In other words, right ventricular stroke volume was decreased by 100% left heart bypass above the critical point of afterload. In conclusion, this study demonstrates not only that bypass of the left side of the heart results in an increase in right ventricular stroke volume in both normal and failing hearts at the physiologic range of afterload, but also that right ventricular function against higher afterload is impaired by 100% assist of bypass of the left side of the heart in failing hearts.     

同行导师体验报告(英文)

Students at the University of Derby are required to complete a year in industry as part of their Bachelor of Science degrees.This is a daunting prospect for some of them,and they can be reluctant to engage in the process of finding a placement position.As part of a second year module,students seeking placement are paired with students already on placement in a mentee/mentor relationship to support the second year students in their search for an internship.This arrangement helps the mentees by introducing them to potential role models close to their experience,receiving encouragement from peers and the inculcation of belief that it is possible to find a placement.The mentors also benefit from a recognition of how much they have learnt.However,there are difficulties in establishing and managing the scheme which should be recognised.This paper reports our experience over the last three years.     

基于P2P的Web工作流管理系统体系结构研究*

传统C/S体系结构的工作流系统通常存在服务器端的资源瓶颈,现有的少数几个基于P2P的工作流系统没有利用Web服务的优势。针对以上不足,提出了一个基于P2P网络的Web工作流管理系统体系结构。系统引入通知机制实现工作流的分布式管理,工作流中活动由Web服务实现,工作流成为一个能够在Internet上调用的服务。系统克服了中央服务器的缺陷,具有较强的适应性、扩展性。     

An index for paresis and defective healing--an easily applied method for objectively determining therapeutic results in facial paresis (author's transl)

Residuals of facial paralysis consist of a great variety of cosmetic and functional anomalies which differ in quality and/or quantity. An internationally standardized evaluation of such defects is mandatory for the assessment of the results of different therapeutic procedures. In the present study, a system has been developed to record the results of facial paralysis following therapy. Such a system does not require specialized training, instrumentation or require significant time for completion. A clearly-defined "Yes-No" evaluation criteria is established which creates a high interscorer reliability. The usefulness of this scoring system was tested by three examiners on 42 patients following facial nerve surgery, with an obtained interscorer reliability of 93%.     

Technology Trends in the Extractive Metallurgy of Zirconium,Titanium, Tantalum and Niobium

The reactive and refractory metals zirconium, titanium, tantalum and niobium have been in commercial production and industrial application over the last 30 years and more. With growing experience, there has been progressive improvement in process and equipment designs in the industrial practice. There has also been a continuous drive to develop entirely new processes, and to diversify the applications of these metals. The paper reviews the present status and the emerging trends, and places the Indian work in the global perspective.     

Stability of discrete-time bilinear systems with constant inputs

In this paper discrete-time bilinear systems are considered. Necessary and sufficient conditions are developed which ensure that for any constant input in an unbounded control domain, the trajectories of the system tend to the origin as time increases.     

Probabilistic prediction of high cycle fatigue reliability of high strength steel butt‐welded joints

The aim of this paper is to develop a probabilistic approach of high cycle fatigue (HCF) behaviour prediction of welded joints taking into account the surface modifications induced by welding and the post‐welding shot peening treatment. In this work, the HCF Crossland criterion has been used and adopted to the case of welded and shot peened welded parts, by taking into account the surface modifications which are classified as follows: (i) the compressive residual stresses, (ii) the surface work‐hardening, (iii) the geometrical irregularities and (iv) the superficial defects. The random effects due to the dispersions of: (i) the HCF Crossland criterion material characteristics (ii) the applied loading and (iii) the surface modifications parameters are introduced in the proposed model. The HCF reliability has been computed by using the ‘strength load’ method with Monte Carlo simulation. The reliability computation results lead to obtain interesting and useful iso‐probabilistic Crossland diagrams (PCD) for different welding and shot peening surface conditions. To validate the proposed method, the approach has been applied to a butt‐welded joint made of S550MC high strength steel (HSS). Four types of specimens are investigated: (i) base metal (BM), (ii) machined and grooved (MG) condition, (iii) As welded (AW) condition and (iv) as welded and shot peened (AWSP) condition. The comparison between the computed reliabilities and the experimental investigations reveals good agreement leading to validate the proposed approach. The effects of the different welded and post‐weld shot peened specimen's surface properties are analysed and discussed using the design of experiments (DoE) techniques.     

X-ray diffraction and H-storage in ultra-small palladium particles

In situ X-ray diffraction (XRD) and gravimetric hydrogen uptake measurements of d ∼ 2–3 nm spherical PdH_x particles have been studied in the temperature and pressure range of 323 < T < 428 K and 0 < P < 10 bar. The Pd particles were protected from sintering with a hydrogen-permeable carbon coating. While only containing ∼300–1000 atoms, the Pd particles were found to exhibit the same fcc structure and lattice constant as the bulk. Our isothermal studies show that, with increasing x, these highly crystalline PdH_x nanoparticles also exhibit a complete transformation from the dilute α solid solution phase to the more concentrated β hydride phase. However, we observed that the character of the α–β phase transition in these nanoparticles is very different from that in the bulk. Indeed, the hydrogen uptake isotherm exhibits a noticeable positive slope in the α + β co-existence region. Furthermore, we also observed a noticeable narrowing of the α + β co-existence region (δx) in the nanoparticles. Also, a significant suppression of the critical temperature T_c for the phase boundary was observed: T_c(nano) ≈ 430 K while T_c(bulk) ≈ 570 K. These results signal a significant change in the thermodynamic behavior of very small hydride nanoparticles that may be common to many other nano-scale metal hydride systems as well.