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52.
53.
Ragan CI 《Metal-Based Drugs》1997,4(3):125-132
Metal ions are believed to participate in many neurodegenerative conditions. In excitotoxic cell death there is convincing evidence for the participation of Ca(2+) and Zn(2+) ions although the exact molecular mechanisms by which these metals exert their effects are unclear. Only in one instance has the metal binding site of metalloenzymes been exploited for therapeutic purposes and this is the use of Li(+) in the treatment of bipolar affective disorder. Again the exact molecular target is not clear but is likely to involve a Mg(2+)-dependent enzyme of an intracellular signalling pathway. In Parkinson's disease, the selective loss of dopaminergic neurones in the substantia nigra may be caused by radical-mediated damage and there is good evidence to suggest that Fe(2+) or (3+) is important in promoting formation of radical species. The evidence that free radicals are important in mediating other neurodegenerative conditions is less strong but still substantial enough to suggest that removal of reactive oxygen species or preventing their formation may be a valid approach to therapy. 相似文献
54.
采用熔融共混法制备了尼龙6/苯乙烯-马来酸酐共聚物/N-苯基马来酰亚胺共混物(PA6/SMA/N-PMI),并利用DSC、TGA及力学性能测试等手段研究了SMA用量对PA6/SMA/N-PMI共混物熔融结晶行为、热学性能以及力学性能的影响。结果表明,共混物的最大分解温度较纯PA6有较大提高;SMA用量的增加,共混物的结晶温度、结晶度以及熔融焓均先降低再升高;当SMA用量为5份时,共混物的弯曲强度、弯曲模量以及热变形温度均达到最大值,分别为113.8、3 053 MPa及61.3℃,较纯PA6分别提高了25.1%、28.0%及19.0%;拉伸强度在SMA用量为7.5份时达到最大值81.4 MPa,较纯PA6提高了17.1%。 相似文献
55.
居民出行产生量BP神经网络预测方法 总被引:2,自引:0,他引:2
居民出行产生量预测是交通需求分析的重要内容之一,预测结果是确定各类城市交通设施发展规模及布局规划的重要依据.通过分析人工神经网络的作用机理和居民出行产生量的影响因素,建立了居民出行产生量预测的四层BP神经网络模型,以土地利用作为输入神经元,以交通区居民出行产生量作为输出单元,以赣州市城市综合交通规划交通调查数据对模型进行了标定与检验,并与出行次数法和回归分析法进行了比较,结果表明BP神经网络模型具有较高的预测精度. 相似文献
56.
润滑油对齿轮的疲劳点蚀寿命有影响,而且影响很大,润滑油选用不当或润滑油质量不高,可使疲劳点蚀寿命降低一半;选用高性能润滑油可使疲劳点蚀寿命提高2~3倍,而高性能润滑油的关键在添加剂的合理复配.通过对鞍钢线材厂使用的国产525油膜轴承油的试验研究,证明国产润滑完全可以替代进口润滑油,不会降低齿轮的疲劳寿命。 相似文献
57.
开关电源电磁干扰抑制分析 总被引:1,自引:0,他引:1
开关电源的电磁干扰对电子设备影响很大。本文针对开关电源工作的不稳定性,分析了开关电源电磁干扰产生的原因,提出了抑制电磁干扰的措施,最后列举了几种最新的抑制电磁干扰电路,并对其工作原理做了分析。 相似文献
58.
The shapes and firing rates of motor unit action potentials (MUAP's) in an electromyographic (EMG) signal provide an important source of information for the diagnosis of neuromuscular disorders. In order to extract this information from EMG signals recorded at low to moderate force levels, it is required: i) to identify the MUAP's composing the EMG signal, ii) to classify MUAP's with similar shape, and iii) to decompose the superimposed MUAP waveforms into their constituent MUAP's. For the classification of MUAP's two different pattern recognition techniques are presented: i) an artificial neural network (ANN) technique based on unsupervised learning, using a modified version of the self-organizing feature maps (SOFM) algorithm and learning vector quantization (LVQ) and ii) a statistical pattern recognition technique based on the Euclidean distance. A total of 1213 MUAP's obtained from 12 normal subjects, 13 subjects suffering from myopathy, and 15 subjects suffering from motor neuron disease were analyzed. The success rate for the ANN technique was 97.6% and for the statistical technique 95.3%. For the decomposition of the superimposed waveforms, a technique using crosscorrelation for MUAP's alignment, and a combination of Euclidean distance and area measures in order to classify the decomposed waveforms is presented. The success rate for the decomposition procedure was 90%. 相似文献
59.
PURPOSE: We identified the incidence and types of genital and urinary anomalies, and established a plan for evaluating the urinary system in the CHARGE association. MATERIALS AND METHODS: We retrospectively reviewed the charts of 32 patients in whom the CHARGE association was diagnosed. RESULTS: Of the 32 patients identified 22 (69%) had genitourinary abnormalities. Genital anomalies, including micropenis, penile agenesis, hypospadias, chordee, cryptorchidism, a bifid scrotum, atresia of the uterus, cervix and vagina, and hypoplastic labia majora, labia minora and clitoris, were present in 18 patients (56%). Of the 24 patients who underwent renal ultrasound 10 (42%) were diagnosed with urinary tract anomalies including a solitary kidney, hydronephrosis, renal hypoplasia and duplex kidneys. Further evaluation revealed vesicoureteral reflux, neurogenic bladder secondary to spinal dysraphism, nephrolithiasis, ureteropelvic junction obstruction and a nonfunctioning upper pole in both duplex kidneys. CONCLUSIONS: There is a high incidence of genitourinary anomalies in the CHARGE association. Because of this high incidence of anomalies, patients with this condition should undergo a careful genitourinary evaluation, including renal and bladder ultrasound, and voiding cystourethrography screening. 相似文献
60.
讨论了基于高性能单片机的双CPU的通用数控系统的设计。系统采用两个高性能单片机为处理器,处理器间相互通信,协调工作。软件采用模块化设计。使用时针对具体数控系统功能要求,将通用系统略加增删,便能满足客户需求,体现了数控系统的通用性。通过在STAR-06TQ数控涂漆机上的实际应用,证明本系统能够满足预期设计要求。 相似文献