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61.
DS Gross PD Schnier SE Rodriguez-Cruz CK Fagerquist ER Williams 《Canadian Metallurgical Quarterly》1996,93(7):3143-3148
Proton transfer reactivity of isolated charge states of the protein hen egg-white lysozyme shows that multiple distinct conformations of this protein are stable in the gas phase. The reactivities of the 9+ and 10+ charge state ions, formed by electrospray ionization of "native" (disulfide-intact) and "denatured" (disulfide-reduced) solutions, are consistent with values calculated for ions in their crystal structure and fully denatured conformations, respectively. Charge states below 8+ of both forms, formed by proton stripping, have similar or indistinguishable reactivities, indicating that the disulfide-reduced ions fold in the gas phase to a more compact conformation. 相似文献
62.
Peter A. Whigham Grant Dick James Maclaurin 《Genetic Programming and Evolvable Machines》2017,18(3):399-405
This response examines the context and implications of the comments to "On the Mapping of Genotype to Phenotype in Evolutionary Algorithms" that appears in this journal. The notion of metaphor is first considered and then the general themes of the commentaries addressed. The response subsequently focuses on representation and operators, noting that many of the comments support our basic premise.The main conclusion is that Sterelny's conditions do form a suitable basis for representation and operator design and that the collection of responses form an excellent basis for further discussion and research in evolutionary computation. 相似文献
63.
Similarity-based image organization and browsing using multi-resolution self-organizing map 总被引:1,自引:0,他引:1
Grant Strong Minglun Gong 《Image and vision computing》2011,29(11):774-786
An algorithm is presented in this paper to facilitate the exploration of large image collections based on visual similarities. Starting with an unordered and unannotated set of images, the algorithm first extracts the salient details into feature vectors using both color and gradient information. The feature vectors are then used to train a self-organizing map which maps high-dimensional feature vectors onto a 2D canvas so that images with similar feature vectors are grouped together. When users browse the image collection, an image collage is generated that selects and displays the most pertinent set of images based on which portion of the 2D canvas is currently in view. Flowing from an overview to details is a seamless operation controlled simply by pan and zoom, with representative images selected in a consistent and predictable way. To make organizing larger image collections practical in interactive time, the organization algorithm is designed to run in parallel on graphics processing units. Overall this paper presents an end-to-end solution that facilitates the surfing of image collections in a fresh way. 相似文献
64.
Incremental Evolution in ANNs: Neural Nets which Grow 总被引:1,自引:1,他引:0
This paper explains the optimisation of neuralnetwork topology using Incremental Evolution;that is, by allowing the network to expand byadding to its structure. This method allows anetwork to grow from a simple to a complexstructure until it is capable of fulfilling itsintended function. The approach is somewhatanalogous to the growth of an embryo or theevolution of a fossil line through time, it istherefore sometimes referred to as anembryology or embryological algorithm. Thepaper begins with a general introduction,comparing this method to other competingtechniques such as The Genetic Algorithm, otherEvolutionary Algorithms and SimulatedAnnealing. A literature survey of previous workis included, followed by an extensive newframework for application of the technique.Finally, examples of applications and a generaldiscussion are presented. 相似文献
65.
Grant W. Petty 《Software》2001,31(11):1067-1076
Physical dimensions and units form an essential part of the specification of constants and variables occurring in scientific programs, yet no standard compilable programming language implements direct support for automated dimensional consistency checking and unit conversion. This paper describes a conceptual basis and prototype implementation for such support within the framework of the standard Fortran 90 language. This is accomplished via an external module supplying appropriate user data types and operator interfaces. Legacy Fortran 77 scientific software can be easily modified to compile and run as ‘dimension‐aware’ programs utilizing the proposed enhancements. Copyright © 2001 John Wiley & Sons, Ltd. 相似文献
66.
67.
Since the introduction of sodium metabisulfite as a food preservative, it has been associated with several idiosyncratic reactions (eg, bronchospasm, oculonasal symptoms, and urticaria/angioedema) in sulfite-sensitive individuals. The pathogenic mechanism of these reactions is not yet understood. We report the case of two crewmen on a shrimp trawler who were found dead in the ship's hold. Their deaths had occurred while they were applying dry sodium metabisulfite, referred to as "shrimp dip" in the shrimping industry. Postmortem examinations showed diffuse pulmonary edema consistent with death secondary to asphyxia. Associated findings were visceral congestion. Although it is possible to measure death from sodium metabisulfite with available records, its potential morbidity cannot be estimated. It is known that sodium metabisulfite can react with acids and water, releasing toxic sulfur dioxide (SO2) gas. In addition, SO2 gas reacts with respiratory tissue forming sulfureous acid, and inducing a pulmonary reaction causing hypoxemia. Furthermore, sodium metabisulfite, compared with sodium bisulfite, has a much greater propensity to release SO2 gas. We conclude that there is a need for improved education regarding the potential side effects of sodium metabisulfite, thus eliminating needless occupational morbidity and mortality. 相似文献
68.
Password memorability and security: empirical results 总被引:2,自引:0,他引:2
Users rarely choose passwords that are both hard to guess and easy to remember. To determine how to help users choose good passwords, the authors performed a controlled trial of the effects of giving users different kinds of advice. Some of their results challenge the established wisdom. 相似文献
69.
This paper investigates two bibliometric problems: the listing of books in a specialist area (ornithology) and the determination
of the citation pattern to individual authors, who often re-issue their books in later editions. James Bond, a Philadelphia
ornithologist, who specialised in the birds of the West Indies, is used as an example of a naturalist whose long career led
to many journal articles and enduring scientific fame through a well-known book. He also attained some unexpected notoriety
through the use of his name by a popular novelist. Methods for the evaluation of his book and associated bird checklists in
comparison with other similar works are presented on the basis of their citations.
This revised version was published online in June 2006 with corrections to the Cover Date. 相似文献
70.
David J. Munk Timoleon Kipouros Gareth A. Vio Geoffrey T. Parks Grant P. Steven 《Structural and Multidisciplinary Optimization》2018,57(2):665-688
To date the design of structures using topology optimization methods has mainly focused on single-objective problems. Since real-world design problems typically involve several different objectives, most of which counteract each other, it is desirable to present the designer with a set of Pareto optimal solutions that capture the trade-off between these objectives, known as a smart Pareto set. Thus far only the weighted sums and global criterion methods have been incorporated into topology optimization problems. Such methods are unable to produce evenly distributed smart Pareto sets. However, recently the smart normal constraint method has been shown to be capable of directly generating smart Pareto sets. Therefore, in the present work, an updated smart Normal Constraint Method is combined with a Bi-directional Evolutionary Structural Optimization (SNC-BESO) algorithm to produce smart Pareto sets for multiobjective topology optimization problems. Two examples are presented, showing that the Pareto solutions found by the SNC-BESO method make up a smart Pareto set. The first example, taken from the literature, shows the benefits of the SNC-BESO method. The second example is an industrial design problem for a micro fluidic mixer. Thus, the problem is multi-physics as well as multiobjective, highlighting the applicability of such methods to real-world problems. The results indicate that the method is capable of producing smart Pareto sets to industrial problems in an effective and efficient manner. 相似文献