超临界水氧化法处理高含量印染废水研究

采用超临界水氧化法对高含量印染废水进行试验研究,考察了废水pH、反应温度、反应压力、氧化剂用量等因素对废水COD去除率的影响.结果表明,改变废水的pH对COD去除率有显著的影响,在pH为9.1、反应温度580℃、反应压力27 MPa,过氧量200%的条件下,经处理的废水COD为47 mg·L-1,去除率达到了99.8%.使用超临界水氧化法能有效地去除印染废水的COD,达到GB 8978-96规定的一级排放标准.     

Electrochemical Monitoring of Paclitaxel‐Induced ROS Release from Mitochondria inside Single Cells

Mitochondria are believed to be the major source of intracellular reactive oxygen species (ROS). However, in situ, real‐time and quantitative monitoring of ROS release from mitochondria that are present in their cytosolic environment remains a great challenge. In this work, a platinized SiC@C nanowire electrode is placed into a single cell for in situ detection of ROS signals from intracellular mitochondria, and antineoplastic agent (paclitaxel) induced ROS production is successfully recorded. Further investigations indicate that complex IV (cytochrome c oxidase, COX) is the principal site for ROS generation, and significantly more ROS are generated from mitochondria in cancer cells than that from normal cells. This work provides an effective approach to directly monitor intracellular mitochondria by nanowire electrodes, and consequently obtains important physiological evidence on antineoplastic agent‐induced ROS generation, which will be of great benefit for better understanding of chemotherapy at subcellular levels.     

隐藏层与文档段落相关的神经网络分类器

文本分类是数据挖掘的重要课题,它是获取信息资源的重要方式之一。根据对具有主题的大量文本的分析,基于神经网络的文本分类器在网络结构上,与文档的标题和段落结构之间建立了严格的对应关系。比较仔细地描述了神经网络的训练算法,包括正向传播算法和反向修正算法,对于算法的主要步骤,给出较详细计算方法。对基于神经网络的文本分类器的测试表明,该神经网络模型参数设置比较简单,其文本分类性能良好。     

丙烯酸的现状与发展趋势

详细介绍了丙烯酸的制备方法，并简要地概括了它的性能和目前的生产和消费状况。最后，展望了今后丙烯酸的发展趋势。     

RS-102221: a novel high affinity and selective, 5-HT2C receptor antagonist

The 5-HT2C receptor is one of three closely related receptor subtypes in the 5-HT2 receptor family. 5-HT2A and 5-HT2B selective antagonists have been described. However, no 5-HT2C selective antagonists have yet been disclosed. As part of an effort to further explore the function of 5-HT2C receptors, we have developed a selective 5-HT2C receptor antagonist, RS-102221 (a benzenesulfonamide of 8-[5-(5-amino-2,4-dimethoxyphenyl) 5-oxopentyl]-1,3,8-triazaspiro[4.5]decane-2,4-dione). This compound exhibited nanomolar affinity for human (pKi = 8.4) and rat (pKi = 8.5) 5-HT2C receptors. The compound also demonstrated nearly 100-fold selectivity for the 5-HT2C receptor as compared to the 5-HT2A and 5-HT2B receptors. RS-102221 acted as an antagonist in a cell-based microphysiometry functional assay (pA2 = 8.1) and had no detectable intrinsic efficacy. Consistent with its action as a 5-HT2C receptor antagonist, daily dosing with RS-102221 (2 mg/kg intraperitoneal) increased food-intake and weight-gain in rats. Surprisingly, RS-102221 failed to reverse the hypolocomotion induced by the 5-HT2 receptor agonist 1-(3-chlorophenyl)piperazine (m-CPP). It is concluded that RS-102221 is the first selective, high affinity 5-HT2C receptor antagonist to be described.     

Cytokine profiles of stimulated blood lymphocytes in asthmatic and healthy adolescents across the school year

T cell cytokines play an important role in mediating airway inflammation in asthma. The predominance of a Th2 cytokine profile, particularly interleukin (IL)-4 and IL-5, is associated with the pathogenesis and course of asthma. The aim of this study was to test the hypothesis that a stressful life event alters the pattern of cytokine release in asthmatic individuals. Thirteen healthy controls and 21 asthmatic adolescents gave blood samples three times over a semester: midsemester, during the week of final examinations, and 2-3 weeks after examinations. Interferon-gamma (IFN-gamma), IL-2, IL-4, and IL-5 were measured from supernatants of cells stimulated with PHA/PMA for 24 h. Cells from asthmatic subjects released significantly more IL-5 during the examination and postexamination periods, whereas cells from healthy controls released significantly more IL-2 during the midsemester and examination periods, thereby indicating a bias for a Th2-like pattern in asthmatics and a Th1-like pattern in healthy controls. IL-4 and IL-5 production showed a marked decrease during and after examinations in healthy controls, whereas this decline was absent in asthmatics. The ratios of IFN-gamma:IL-4 and IFN-gamma:IL-5 also revealed significant changes in the profile of cytokine release across the semester. These results indicate differential cytokine responses in asthmatics that may become pronounced during periods of cellular activation.     

Geology of the tengchong geothermal field and surrounding area, West Yunnan, China

This paper describes the regional tectonics, active structures and thermal springs of the Tengchong geothermal field and surrounding area. Regional tectonic evidence shows that Tengchong and the surrounding area was a microcontinent between the Gondwanaland and Eurasian plates. The distribution of the thermal springs is controlled by active faults in the “arched” and circular structures. The majority of the thermal areas have a deep circulation within the fault system. Only a few high-temperature hydrothermal systems issuing sodium chloride may be heated by a local magmatic source.     

Distributed adaptive control for vehicular platoon with unknown dead‐zone inputs and velocity/acceleration disturbances

This paper is focused on designing a distributed adaptive control scheme for a vehicular platoon with unknown bounded velocity/acceleration disturbances and unknown nonlinear dead‐zone inputs. Our aim is to design distributed adaptive controllers based on integral sliding mode control techniques that guarantee practical exponential convergence (i.e., exponential stability of an arbitrarily small neighborhood of zero) of the spacing errors and the string stability of the whole vehicular platoon. The contributions of this paper are that: (i) based on a modified constant time headway policy, the whole vehicular platoon is guaranteed to have string stability despite dead zone inputs; (ii) adaptive compensation terms are constructed to compensate for the time‐variant effects caused by unknown bounded velocity/acceleration disturbances, and unknown dead zone inputs; (iii) an efficient numerical method for avoiding the singularity problem of the control law is also proposed. Numerical simulation results show the validity and advantages of the proposed method are significantly higher traffic density and string stability. Copyright © 2016 John Wiley & Sons, Ltd.     

降低板坯纵裂纹生产实践

针对新钢第一炼钢厂板坯1号连铸机纵裂纹现状,对其产生原因进行分析,指出目前水口对中差、液面波动大、保护渣液渣薄是三大主因,并提出了有效解决措施,降低了纵裂纹的下线率和轧后发生率,确保了生产顺行和产品质量稳定.