Accuracy of an automated blood pressure device in stable inpatients: optimum vs routine use

OBJECTIVES: The review lists the child psychiatry day-care centres in Quebec, evaluates their capacity, and describes them according to the age range for admission, the psychopathologies treated, and the parent involvement required. METHOD: The 26 programs selected, which are all associated with a hospital centre, assess and treat children aged 0 to 12 years on a day-care basis. Organization, clinical operation, and research are addressed during a semisupervised interview. RESULTS: The average capacity is 18 children (4 to 40), with a total capacity of 454 children. The number of preschool patients can be compared with the number of school patients. Few programs are dedicated to invasive development disorders, and one-third treat behavioural or emotional disorders. The larger capacity programs treat patients of both genders. Most programs are eclectic and encourage but do not require parental involvement. CONCLUSIONS: Results take into account different theoretical influences, the controversy about integration criteria and parent involvement, and the specificity of the child psychiatry mission.     

Discovery and preliminary SAR studies of a novel, nonsteroidal progesterone receptor antagonist pharmacophore

A series of 6-aryl-1,2-dihydro-2,2,4-trimethylquinolines was synthesized and tested for functional activity on the human progesterone receptor isoform B (hPR-B) in mammalian (CV-1) cells. The lead compound LG001447 (1,2-dihydro-2,2, 4-trimethyl-6-phenylquinoline) was discovered via directed high throughput screening of a defined chemical library utilizing an hPR-B cotransfection assay. Electron-withdrawing substituents at the meta position of the C(6) aryl group afforded substantial improvements in hPR modulatory activity. Several analogues were able to potently block the effects of progesterone in vitro. Two compounds, 10 (LG120753) and 11 (LG120830) with potencies comparable or equal to the steroidal hPR antagonist onapristone (ZK98,299), were demonstrated to act as antiprogestins in vivo after oral administration to rodents. This is the first disclosure of orally active nonsteroidal antiprogestins.     

Evaluation of the factor structure and psychometric characteristics of the General Well-Being Schedule (GWB) with Mexican American women

The General Well-Being Schedule (GWB) is a brief, reliable, and valid measure of subjective well-being that is widely used in research as an indicator of psychological health and dysfunction. The GWB is hypothesized to have six subscales or dimensions (anxiety, depression, positive well-being, self-control, vitality, and general health), but previous research has not yielded a consistent factor structure. Little attention has been paid to the reliability and validity of the GWB with Mexican-Americans, the fastest growing minority group in the U.S. The purpose of this study was to evaluate the reliability and validity of the GWB schedule with Mexican-American women involved in a community-based weight-loss study. Factor analysis indicated a four-factor solution. The GWB and the resulting factors demonstrated acceptable reliability and discriminability.     

Association between in vitro heterophil function and the feathering gene in commercial broiler chickens

We recently showed that in vitro heterophil functional efficiency in commercial broiler chickens is genetically controlled and may be a sex-associated trait. To further characterize the genetic mechanism(s) of heterophil functional efficiency, we wanted to determine whether the feathering gene, present on the Z sex chromosome, contributes to heterophil functional efficiency. Heterophils from two pairs of broiler lines were evaluated; each pair contained a fast feather (FF) (lines A and X) and a slow feather (SF) line (lines B and Y). On days 1 and 4 post-hatch, heterophils isolated from two sets of pure line broilers (A and B, and X and Y) were evaluated for their ability to (1) phagocytize Salmonella enteritidis, and (2) exhibit bactericidal activity against S. enteritidis. On days 1 and 4 post-hatch, heterophils isolated from the FF lines were statistically (P < or = 0.02) more proficient at phagocytizing S. enteritidis than heterophils from SF lines. Bactericidal activity was also statistically (p < or = 0.02) greater on day 1 post-hatch in the heterophils isolated from FF lines compared to heterophils isolated from SF lines. These data indicate that the presence of the FF gene locus on the Z sex chromosome contributes to heterophil function and may contribute to the early innate immune competence of a flock.     

Partial characterization of a cell-directed inhibitor of leukotaxis in human serum

A leukotactic defect is described in a man with a low cerebrospinal fluid leukocyte count in the presence of an acute listeria meningitis. On the basis of subsequent studies with his serum and normal human serum, a leukotactic inhibitor has been identified. This inhibitor, termed the cell-directed inhibitor (CDI), is relatively heat stable and nondialyzable. By ultracentrifugal analysis in sucrose density gradient, the inhibitor has been resolved into two activities with estimated sedimentation coefficients of 7 and 10 S. It interacts directly with neutrophils and monocytes to render them chemotactically defective. CDI also impairs the phagocytic function of neutrophils. Evidence is presented that an antagonist to the inhibitor is present in normal serum. CDI and its antagonist are probably normally occurring regulators of leukotaxis. In the patient studied, an elevated CDI serum level may be related to the development of the listeria infection and failure of cutaneous response to skin test antigens.     

Acute renal failure secondary to acute pyelonephritis

A six year-old girl presented with acute oliguric renal failure, secondary to acute, non-obstructive pyelonephritis. Evidence for pyelonephritis as the cause of renal failure included: the evolution of typical changes on serial intravenous pyelograms, an acute interstitial inflammatory exudate on percutaneous renal biopsy, and gram-positive cocci on gram stain of the biopsy tissue. Although a specific causative organism was not conclusively identified, enterococcus was isolated from the initial catheterized urine specimen. The patient recovered from the acute illness but was left with impaired renal function, hypertension, and cortical scarring. Acute, non-obstructive pyelonephritis can produce acute renal failure in children and must be considered in the differential diagnosis of this syndrome.     

Forced Convection Heat Transfer to Power-Law Non-Newtonian Fluids Inside Triangular Ducts

A hybrid analytical-numerical approach based on the Generalized Integral Transform Technique is employed to simulate the laminar forced convection (hydrodynamically fully developed and thermally developing laminar flow) of power-law non-Newtonian fluids inside ducts with arbitrary shaped cross-sections. The analysis is illustrated through consideration of both right angularly and isosceles triangular ducts subjected to constant wall temperature as thermal boundary condition. Reference results for quantities of practical interest such as dimensionless average temperature and Nusselt numbers within the thermal entry region were produced for different values of power-law index and apex angles. Finally, critical comparisons are performed with results available in the literature for direct numerical and approximate approaches.