Spinal myoclonus induced by an intrathecal catheter

This 9-year-old boy presented with a multifocal, apparently noninfectious granulomatous process involving the central nervous system. Despite gross-total excision of the large left temporal lesion, it recurred after surgery. Serological studies and cultures failed to demonstrate an infectious agent, and histopathological investigation showed a nonspecific granulomatous process without vasculitis. The patient underwent a second craniotomy and was given corticosteroid therapy. There has been no recurrence during 3 years of follow-up review, the last year of which included no course of steroid medications. The case is presented as a noninfectious idiopathic granulomatous encephalitis that is responsive to surgery and corticosteroid therapy. To the authors' knowledge, it is the first reported case of its kind.     

Gender differences in moral reasoning: A comparison of the use of justice and care orientations.

Examined the adequacy of L. Kohlberg's (1971) cognitive-developmental model as a representation of female moral reasoning. Specifically, the claims of C. Gilligan (1982) that there are 2 conceptions of morality—one described as a morality of justice, on which Kohlberg's scheme is based, and one described as a morality of care, seen by Gilligan as more representative of female thinking about moral conflict—were studied. 101 male and 101 female undergraduates filled out a self-report questionnaire on moral dilemmas they had experienced. They then rated their use of both justice and care orientations in resolving those dilemmas. Ss also completed the Interpersonal Disposition Inventory and semantic differential items. The use of the 2 orientations was examined in relationship to S gender, sex role, and perceptions of the 2 orientations. Few significant differences were obtained, except that female Ss were more consistent in their use of a care orientation and male Ss were more consistent in their use of a justice orientation. More feminine males were more likely to report the use of a care orientation than less feminine males. Male and female reasoning about moral conflict is examined in the light of these 2 perspectives, and the relationship of sex roles to endorsement of each perspective is discussed. (23 ref) (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

Identification of a novel inhibitor (NSC 665564) of dihydroorotate dehydrogenase with a potency equivalent to brequinar

A novel inhibitor of dihydroorotate dehydrogenase (DHO-DH) has been discovered using data from the National Cancer Institute's in vitro drug screen. Upon analysis of cytotoxicity results from the sixty tumor cell lines used in this screen, the COMPARE program predicted that NSC 665564 was likely to have the same mechanism of inhibition as brequinar, a known potent inhibitor of DHO-DH. We validated this prediction experimentally using MOLT-4 lymphoblast and found the IC50 of brequinar (0.5 microM) and NSC 665564 (0.3 microM) were comparable and that this induced cytotoxicity was reversed by either uridine or cytidine. The enzyme target of NSC 665564 was shown to be identical to that of brequinar when incubation with each drug followed by a 1 h pulse with [14C] sodium bicarbonate resulted in cellular accumulation of [14C]N-carbamyl-L-aspartic acid and [14C]L-dihydroorotic acid, with concurrent marked depletion of CTP and UTP. The Ki's for NSC 665564 and brequinar were 0.14 and 0.24 microM, respectively, when partially purified MOLT-4 mitochondria (the site of DHO-DH) were used. These results show that mechanistic predictions obtained using correlations from the COMPARE algorithm are independent of structure since the structure of NSC 665564 is dissimilar to that of other established DHO-DH inhibitors.     

Verbal Representation and Therapeutic Change in Anaclitic and Introjective Inpatients.

This study examined the relation between changes in clinical functioning and changes in verbal expression in 81 seriously disturbed and treatment-resistant young adults seen in a comprehensive, psychoanalytically oriented inpatient treatment. Clinical functioning was evaluated with a battery of clinical and social measures. Verbal representations were assessed using computer-assisted scoring of Thematic Apperception Test responses. Changes in the frequency of verbal content and style in the narratives of these patients covaried with changes in clinical functioning. Significantly different covariations of verbal and clinical change, particularly differences in covariates of referential activity, were found for patients with anaclitic versus introjective personality configurations. The implications of these findings for understanding and treating severe psychopathology are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Improved dynamic cutting force model in ball-end milling. Part I: theoretical modelling and experimental calibration

An accurate cutting force model of ball-end milling is essential for precision prediction and compensation of tool deflection that dominantly determines the dimensional accuracy of the machined surface. This paper presents an improved theoretical dynamic cutting force model for ball-end milling. The three-dimensional instantaneous cutting forces acting on a single flute of a helical ball-end mill are integrated from the differential cutting force components on sliced elements of the flute along the cutter-axis direction. The size effect of undeformed chip thickness and the influence of the effective rake angle are considered in the formulation of the differential cutting forces based on the theory of oblique cutting. A set of half immersion slot milling tests is performed with a one-tooth solid carbide helical ball-end mill for the calibration of the cutting force coefficients. The recorded dynamic cutting forces are averaged to fit the theoretical model and yield the cutting force coefficients. The measured and simulated dynamic cutting forces are compared using the experimental calibrated cutting force coefficients, and there is a reasonable agreement. A further experimental verification of the dynamic cutting force model will be presented in a follow-up paper.     

Creating trauma-informed systems: Child welfare, education, first responders, health care, juvenile justice.

Children and adolescents who are exposed to traumatic events are helped by numerous child-serving agencies, including health, mental health, education, child welfare, first responder, and criminal justice systems to assist them in their recovery. Service providers need to incorporate a trauma-informed perspective in their practices to enhance the quality of care for these children. This includes making sure that children and adolescents are screened for trauma exposure; that service providers use evidence-informed practices; that resources on trauma are available to providers, survivors, and their families; and that there is a continuity of care across service systems. This article reviews how traumatic stress impacts children and adolescents' daily functioning and how various service systems approach trauma services differently. It also provides recommendations for how to make each of these service systems more trauma informed and an appendix detailing resources in the National Child Traumatic Stress Network that have been produced to meet this objective. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Evaluation of the effect of tracer pH on the sealing ability of glass ionomer cement and mineral trioxide aggregate

OBJECTIVES: The aim of this study was to evaluate the sealing ability and physical and chemical properties of glass ionomer cement (GIC) and mineral trioxide aggregate (MTA) using Rhodamine B at different pHs as tracer. METHODS: Chemical analysis, pH and micro-hardness of GIC and MTA were performed. In addition dye leakage was assessed by tracer leakage using Tandem Scanning Confocal Microscope (TSM) after immersion of premolar teeth in a stock and a buffered fluorescent Rhodamine B for 24 h. Ultra-structural changes within the materials were evaluated by viewing under the field emission scanning electron microscope (FESEM). RESULTS: GIC and MTA showed elemental peaks for silicon, aluminium and calcium while MTA also had bismuth. GIC was acidic (P = 0.001) and caused an increase in dye pH (P = 0). Immersion of MTA in any of the test solutions resulted in an increase in the pH of the solution (P < 0.05). Use of a dye solution of lower pH than the material under test increased the cement micro-hardness. GIC demonstrated marginal leakage on TSM and both increase in marginal leakage and material porosity on FESEM. MTA was not affected by the use of acidic dye but showed a tendency to take up dye within the material shown on TSM. CONCLUSIONS: Evaluation of marginal adaptation of dental materials was shown to be dependent on the technique used for viewing the material to tooth interface, the properties of the material under study and the pH of the dye used.     

First lady [Hertha Ayrton biography]

This paper presents a biography of Hertha Ayrton, celebrated as the first woman member of the IEE. The author writes that this feat should not obscure her many other achievements