Synthesis and comparative molecular field analysis (CoMFA) of antitumor 3-arylisoquinoline derivatives

In this study a series of 3-arylisoquinoline derivatives were synthesized and cytotoxicity against human melanoma tumor cell evaluated, and a three dimensional quantitative structure-activity relationship was investigated using the comparative molecular field analysis (CoMFA). The results suggested that the electrostatic, steric and hydrophobic factors of 3-arylisoquinolines were strongly correlated with the antitumor activity. Considerable predictive ability (cross-validated r2 as high as 0.721) was obtained through CoMFA.     

An experimental study of the flow of dry powders over inclined surfaces

The behavior of dry particulate solids during unconfirmed flow over inclined surfaces has been investigated. The motion of individual particles is found to depend strongly on the nature of the surface over which they flow. For smooth surfaces, flow occurs primarily by sliding at the surface, and little or no shear is introduced into the stream. In the case of highly roughened surfaces consisting of, for example, a stationary layer of the same particles, there appears to be no slip at the surface, and flow occurs entirely by shear within the flowing stream. Surfaces of intermediate roughness lead to flow in which both slip at the surface and shear within the bed contribute significantly.Velocity profiles have been measured experimentally under a variety of conditions, and the effects of such variables as roughness and inclination of the surface, depth of the flowing stream and particle size have been evaluated quantitatively. Empirical relationships have been obtained which describe the flow behavior in all cases studied.     

国内外通用型金属封闭开关设备技术动态（一）

本文介绍通用型金属封闭关设备的国内外总本技术水平,目前产品的结构与特点,国内 自行设计和引进技术以及今后产品发展的前景。     

LED照明亮度控制新技术特征与应用

随着LED应用的不断增加,大功率LED的驱动控制日显重要。本文分析介绍了LED照明亮度控制的新技术特征与应用。     

Low-Dimensional Waveguide Grating Fabrication in GaN with Use of SiCl<Subscript>4</Subscript>/Cl<Subscript>2</Subscript>/Ar-Based Inductively Coupled Plasma Dry Etching

Optimized fabrication of submicron-sized features in gallium nitride (GaN) with the use of inductively coupled plasma (ICP) dry etching, based on SiCl₄/Cl₂/Ar gas mixture, is presented. Dense periodic patterns, i.e., 400-nm-period gratings, were transferred into a gallium nitride waveguide under different etching conditions. ICP power, radiofrequency (RF) power, chamber pressure, and Ar/Cl₂ gas mixing ratio were altered during the experiment. Depths of fabricated grating couplers up to 670 nm were achieved. The most suitable etching conditions are discussed with the assessment based on etching selectivity, scanning electron microscopy (SEM) observation of grating tooth slope, hard-mask erosion process, and etched surface morphology.     

离退休人员门诊规范化服务

该文对微机械气流式水平姿态传感器敏感机理进行了三维的有限元分析.利用ANSYS-FLOTRAN CFD软件,通过建模、划分网格、加载和求解等途径,计算了微机械气流式水平姿态传感器敏感元件密闭腔体中气流速度在不同倾斜状态下的分布.阐明微机械气流式水平姿态传感器的敏感机理,为气流式水平姿态传感器的优化设计开辟了更精确的研究途径.     

High-Power 1.3-μm Quantum-Dot Superluminescent Light-Emitting Diode Grown by Molecular Beam Epitaxy

In this letter, we demonstrate the improved performance of 1.3-mum seven-layered InAs-GaAs quantum-dot superluminescent light-emitting diodes by the engineering of the epitaxial growth conditions alone, namely the thickness of the low-temperature GaAs spacer layer between quantum-dot layers. For laser devices, a significant reduction in threshold current density and increase in external efficiency is observed, while for superluminescent diode structures, a ~4 fold increase in CW power at a given drive current is obtained     

Wet Reflectors in Millimeter-Wave Radiometry-Expenrment and Theory

Microwave radiometers are often required to operate under all weather conditions, including those under which an exposed surface of the antenna system becomes wetted by rain. Here we discuss the special case of a wetted flat reflector, with energy at 20.60 and 31.65 GHz linearly and orthogonally polarized at an incidence angle of 45°. The brightness temperatures produced by the wet reflector are computed from conventional theory, and are measured for various thicknesses of water layer. Both theory and experiment show that the brightness temperatures produced by the wet reflector have the same behavior throughout a range of water-layer thicknesses. The impact of these results on design of radiometers for research and operational application is discussed.     

Seasonal effects on the response of ovarian follicles to IGF1 in mares

The response of follicles to IGF1 was compared between the transition into the ovulatory season (transitional period) and the ovulatory season (ovulatory period) in eight mares using a cross-over experimental design within periods. Granulosa cells were collected from follicles 15-24 or 25-34 mm and expression of IGF1R, IGF2R, FSHR, LHCGR and PAPPA was determined by qPCR. In addition, 10 mg IGF1 or vehicle were injected into the largest follicle (transitional period) or the second largest follicle (ovulatory period) of a follicular wave before the beginning of diameter deviation between the two largest follicles (mean diameters at injection 19.2 and 20.0 mm during transitional and ovulatory periods respectively). Follicular fluid was collected 24 h after injection for determination of free IGF1, IGFBP, inhibin A and oestradiol levels. Granulosa cells from follicles 25-34 mm, but not follicles 15-24 mm, expressed higher levels of IGF1R (P=0.01), FSHR (P<0.007) and LHCGR (P=0.09) during the ovulatory period than during the transitional period, whereas IGF2R expression was higher in transitional than ovulatory follicles (P=0.06). Follicular IGFBP2 levels were not different (P>0.1) between periods and treatments, whereas IGFBP5 levels were higher (P<0.05) during the ovulatory period. Finally, IGF1 injection before the beginning of deviation induced an approximately twofold increase (P=0.01) in follicular inhibin A levels during each period and did not affect oestradiol (P>0.1). These results suggest that, as during ovulatory waves, equine follicles during transitional waves are responsive to IGF1 before the beginning of deviation and that, therefore, inadequate IGF1 responsiveness before deviation may not underlie the deficient development of dominant follicles during transition.