A multistage amplifier technique with embedded frequencycompensation

A new multistage operational amplifier topology requires only N-2 embedded compensation networks for N gain stages. The compensation circuits do not load the output stage, and noninverting gain stages are not required as in previous multistage approaches. Consequently, high gain, wide bandwidth, fast slewing, and excellent power efficiency are achieved. A low-power resistance-capacitance compensation technique assures stability and fast settling over process, voltage, and temperature variations. Implemented in a 0.6-μm n-well CMOS process, a single ended three-stage prototype dissipates 6.9 mW at 3.0 V with 102 dB gain, 47 MHz bandwidth, and 69 V/μs average slew rate with 40 pF load     

CMOS retinal prosthesis with on-chip electrode impedance measurement

A retinal prosthesis device with built-in self-test capability is proposed and demonstrated. The measurement of electrode impedance as a self-test is achieved without increasing the chip area by employing analogue multiplexers to allow the electrodes to be used for both stimulation of retinal cells and measurement of impedance. Measurement is performed using a four-terminal method to ensure good accuracy. A prototype stimulus chip with 16/spl times/16 channels is fabricated using standard 0.6 /spl mu/m CMOS technology, and is demonstrated to provide self-test functionality with error of as little as 0.05% in the frequency range of 100 Hz to 100 kHz.     

Fast minimization methods for solving constrained total-variation superresolution image reconstruction

In this paper, we study the problem of reconstructing a high-resolution image from several decimated, blurred and noisy low-resolution versions of the high-resolution image. The problem can be formulated as a combination of the total variation (TV) inpainting model and the superresolution image reconstruction model. The main purpose of this paper is to develop an inexact alternating direction method for solving such constrained TV image reconstruction problem. Experimental results are given to show that the proposed algorithm is effective and efficient.     

Injectable Collagen–Genipin Gel for the Treatment of Spinal Cord Injury: In Vitro Studies

Spinal cord injury (SCI) often results in a cavitary lesion, contained within the dura, which involves only a portion of the cord. Injectable biopolymers are an attractive treatment option for SCI to re‐establish cell migratory pathways within the lesion while minimizing the collateral damage attendant to an open surgical procedure. In this study we evaluate a thermoresponsive soluble collagen gel incorporating genipin, an amine reactive covalent cross‐linker with low cytotoxicity and fluorogenic attributes. Unlike previous studies, genipin is being investigated as an in situ covalent cross‐linker that will continue to act on the gel after injection. Physical characterization studies show that the addition of genipin provides control over the mechanical and degradative behavior of the gel, to meet design specifications of an injectable material for neural tissues. Additionally, an improved in situ assay to predict the extent of cross‐linking reaction is investigated. Encapsulation of mesenchymal stem cells (MSCs) in collagen–genipin gels show the gels support cell viability and proliferation, and thus serve as a cell delivery vehicle. Neural stem cells are found to be more sensitive to genipin, with respect to toxicity, as compared to MSCs. From our studies, 0.25‐0.5 mM is an appropriate genipin concentration to use for an in situ forming scaffold capable of delivering cells and therapeutic agents.     

Efficient FPGA implementation of bit-stream multipliers

A four-input adder structure for the FPGA implementation of a sigma-delta bit-stream multiplier is proposed. Conventional bit-stream multiplier implementations involve two-input adder circuits. It is shown that the four-input adder structure is more resource-efficient (over 40% hardware savings) and faster (over 20% higher clock frequency) when implemented using state-of-the-art FPGA architecture featuring six-input look-up tables     

The biomechanics of lumbar graded facetectomy under anterior-shear load

In this paper, an anatomically accurate three-dimensional finite-element (FE) model of the human lumbar spine (L2-L3) was used to study the biomechanical effects of graded bilateral and unilateral facetectomies of L3 under anterior shear. The intact L2-L3 FE model was validated under compression, tension, and shear loading and the predicted responses matched well with experimental data. The gross external (translational and coupled) responses, flexibilities, and facet load were delineated for these iatrogenic changes. Results indicted that unilateral facetectomy of greater than 75% and bilateral facetectomy of 75% or more resection markedly alter the translational displacement and flexibilities of the motion segment. This study suggests that fixation or fusion to restore strength and stability of the lumbar spine may be required for surgical intervention of greater than 75% facetectomy.     

Numerical investigation of self-heating effects of oxide-confined vertical-cavity surface-emitting lasers

We present a comprehensive numerical model to simulate self-heating effects of oxide-confined vertical-cavity surface-emitting lasers (VCSELs) under continuous-wave operation. The model self-consistently accounts for the close interaction between optical, electrical, and thermal processes in VCSELs. In particular, hot carriers and nonequilibrium optical phonons in the quantum wells are modeled by solving a carrier energy balance equation and an optical phonon rate equation. Our numerical simulations reveal that they are responsible for aggravated thermal rollovers in VCSELs' L-I characteristics. Detailed comparisons are made and good agreement is obtained between simulations and experiments for the L-I-V and lasing wavelength characteristics of VCSELs with varying oxide aperture size. Various mechanisms that result in the L-I thermal rollover behavior are also investigated with the aid of simulations.     

Control of high common mode voltage during transthoracicdefibrillation

A high common mode voltage (V_cm) relative to earth ground is produced on the myocardium during the delivery of a defibrillator pulse and can generate a differential error signal when potential gradients are recorded with bipolar electrodes and isolation amplifiers. The error signal is proportional to V_cm, and therefore, a reduction in V_cm improves the accuracy of the potential gradient data. Experiments were conducted on 5 dogs to determine whether V_cm can be controlled using a bridge circuit. The bridge circuit consisted of a 5 kΩ power rheostat in parallel with the transthoracic resistance of the dog. The variable contact of the rheostat was connected to earth ground, and by adjusting the rheostat, V_cm on the myocardium could be varied. In each dog, 20 A shocks were delivered through stainless steel transthoracic electrodes. Point contact electrodes sutured to the epicardium were used to measure V_cm. It was determined that V_cm could be reduced to approximately zero at a given electrode on the heart. In addition, for the 5 dogs studied, the maximum measured V_cm on the heart was only 10% of the transthoracic voltage when the bridge circuit was balanced for an interior point in the heart     

On the use of Reed-Solomon codes in improving digital FMtransmission performance in Rayleigh fading

Reed Solomon codes with interleaving are used in a binary FM transmission affected by Rayleigh fading as encountered in land mobile radio. A new decoding algorithm is proposed which can be implemented in simple hardware. The error performance of the binary FM system with the RS code with one and two degrees of interleaving is measured. A significant reduction of error rate floor as a function of fading speed is noted and discussed     

DOA estimation of wideband sources without estimating the number of sources

In this paper, we propose a new technique to estimate wideband source directions from the sensor snapshots without requiring to know the number of sources present in the scenario. This work is motivated by the fact that the existing model order estimation (number of sources) techniques for wideband source scenario are either inaccurate or computationally expensive. Direction-of-arrival (DOA) estimation is realized using a beamformer framework which imposes nulls in the spatial spectrum along the source directions. The null width along the frequency axis is widened by introducing a new data dependent term into the optimization problem, thus achieving wideband capability. Furthermore, the temporal processing of the data snapshots drastically reduces the number of snapshots required for wideband DOA estimation. The effectiveness of the proposed formulation is studied with simulated experiments.