Differential effects of elevated potassium ion concentration and of theophylline on growth hormone release by rat adenohypophyses in vitro

The effects of 27 mM K+ and of 6.7 mM theophylline on the release of growth hormone (GH) by rat hemipituitaries in vitro were investigated using bioassay (rat tibia test) and radioimmunoassay (RIA). Both agents markedly increased the release of immunoreactive GH. High K+ also promoted the release of bioactive GH but to a much lesser degree than RIA-GH. Theophylline did not consistently affect the release of bioassay-detectable GH. The results suggest that these agents promote massive release of a form of immunoreactive GH (possibly "immature") that has little or no activity in the bioassay. Theophylline is relatively more effective in this regard than is elevated K+.     

Fractal analysis of pressure fluctuations in a three phase bubble column reactor operating at low pressure

Pressure fluctuations in a three phase bubble column reactor operating at relatively low pressure (92 KPa) have been analyzed by adopting the spectral and fractal analyses to get the engineering informations for the on-line control and fault diagnosis of the reactors. The mean value, standard deviation, skewness and kurtosis of the pressure fluctuations have been obtained. The local fractal dimension has been determined from the Pox diagram obtained by means of the rescaled range analysis of the pressure fluctuations based on the fractional Brownian motion. The local fractal dimension of pressure fluctuations has increased and thus the pressure fluctuation signals have become less persistent and irregular, with increases in the gas flow rate reaction temperature, particle size and solid content in the slurry phase. The local fractal dimension has been well correlated in terms of the operating variables.     

Fully plastic analyses for notched bars and plates using finite element limit analysis

In the present work, fully plastic analyses for notched bars and (plane strain) plates in tension are performed, via finite element (FE) limit analysis based on non-hardening plasticity, from which plastic limit loads and stress fields are determined. Relevant geometric parameters are systematically varied to cover all possible ranges of the notch depth and radius. For the limit loads, it is found that the FE solutions for the notched plate agree well with the existing solution. For the notched bar, however, the FE solutions are found to be significantly different from known solutions, and accordingly the new approximation is given. Regarding fully plastic stress fields, it is found that, for the notched plate, the maximum hydrostatic (mean normal) stress overall occurs in the center of the specimen, which strongly depends on the relative notch depth and the notch radius-to-depth ratio. On the other hand, for the notched bar, the maximum hydrostatic stress can occur in between the center of the specimen and the notch tip. The maximum hydrostatic stress for a given notch depth can occur not for the cracked case, but for the notched case with a certain radius. This is true for both bars and plates. For a given notch radius, on the other hand, the maximum hydrostatic stress increases monotonically with the decreasing notch radius.     

Comments on “Quadratic stabilization of continuous timesystems with state-delay and norm-bounded time-varyinguncertainties”

In the above mentioned paper by Mahmoud-Muthairi (ibid. vol.39 (1994)) a sufficient condition for memoryless stabilization of a class of uncertain linear systems with a variable-state delay and norm-bounded time-varying uncertainties is derived in terms of an algebraic Riccati equation. This Riccati equation depends on several free matrix variables, and a subsequent result in the paper, Theorem 2, states that failure or success of the stabilization algorithm is independent of the selection of these matrix variables. In this paper, we give a counterexample to this Theorem 2 as well as providing a fix     

Using regression splines to assess the impact of information technology investments on productivity in the health care industry

Abstract. This paper explores the impact of information technology (IT) investments on productivity using a new technique, multivariate adaptive regression splines (MARS). We believe that it provides additional insights on the nature of the impact of IT investments on productivity. The results from our study are compared with findings from a previous study that has also used the same data set. While the results of a previous study indicate that IT investments have a positive but uniform impact on productivity, our study suggests that the impact of IT on productivity is not uniform but is contingent on other complementary factors. Our findings describe that the complementary relationship exists between IT and non‐IT related investments. Thus, improved organizational productivity cannot be expected from investment in IT alone but only together with non‐IT investments. Our findings also point out that further investment may not necessarily bring on higher organizational productivity.     

Internet-based Real-time obstacle avoidance of a mobile robot

In this research, a remote control system has been developed and implemented, which combines autonomous obstacle avoidance in real-time with force-reflective tele-operation. A teleoperated mobile robot is controlled by a local two-degrees-of-freedom force-reflective joystick that a human operator holds while he is monitoring the screen. In the system, the force-reflective joystick transforms the relation between a mobile robot and the environment to the operator as a virtual force which is generated in the form of a new collision vector and reflected to the operator. This reflected force makes the tele-operation of a mobile robot safe from collision in an uncertain and obstacle-cluttered remote environment. A mobile robot controlled by a local operator usually takes pictures of remote environments and sends the images back to the operator over the Internet. Because of limitations of communication bandwidth and the narrow viewangles of the camera, the operator cannot observe shadow regions and curved spaces frequently. To overcome this problem, a new form of virtual force is generated along the collision vector according to both distance and approaching velocity between an obstacle and the mobile robot, which is obtained from ultrasonic sensors. This virtual force is transferred back to the two-degrees-of-freedom master joystick over the Internet to enable a human operator to feel the geometrical relation between the mobile robot and the obstacle. It is demonstrated by experiments that this haptic reflection improves the performance of a tele-operated mobile robot significantly.     

Field measurement and estimation of ventilation flow rates by using train-induced flow rate through subway vent shafts

This study measured and estimated the subway vent shaft air flow rate induced by moving trains in the tunnel. This work estimated the flow rate via the tunnel structure and train movement to determine the quantitative effect of vent shafts as air purification systems of natural ventilation to improve the air quality management of a subway. The amount of air suctioned into the tunnel is significantly larger than that vented from the tunnel. Thus, placing vent shafts near subway stations is desirable for natural ventilation systems. Experimental approaches to measure train-induced flow rates have not yet been published. Results of this study provide useful fundamental data to study the natural ventilation in a subway. Therefore, this study suggested the significant design factors required to control indoor air quality in a subway.     

Layered Nanoprobe for Long‐Lasting Fluorescent Cell Label

A long‐lasting particle‐based fluorescent label is designed for extended cell imaging studies. This onion‐like nanoprobe is constructed through layer‐by‐layer fabrication technology. The nanoprobes are assembled with multiple layers of optically quenched polyelectrolytes, the fluorescence signal of which can be released later by intracellular proteolysis. Upon incubation with cells, the assembled nanoprobes are taken up efficiently. The tight packing and layered assembly of the quenched polyelectrolytes slow subsequent intracellular degradation, and then result in a prolonged intracellular fluorescence signal for up to 3 weeks with no noticeable toxicity.     

Identification of cellulolytic bacteria associated with tunic softness syndrome in the sea squirt, Halocynthia roretzi

The edible ascidian, sea squirt Halocynthia roretzi (Drasche) is marine invertebrate that is a valuable source of foods and bioactive compounds. A severe disease of the sea squirt characterized by degeneration of tunic fibers formed of bundled cellulose microfibrils has occurred. We hypothesized that bacteria lyse the cellulose fibril structure, cellulase activity may be a causative agent of the disease. Among the bacteria isolated from diseased sea squirt, Pseudoalteromonas sp. NO3 had cellulase activity based on a Congo red overlay assay and starch-reducing activity. Sea squirts exhibited 40–100% cumulative mortality after injection with Pseudoalteromonas sp. NO3 using doses of 2×10⁶?2×10⁸ colony forming unit (CFU)/individual. Dead sea squirts possess thinner and ruptured tunics, which were similar to natural outbreaks. These results suggest that Pseudoalteromonas sp. NO3 possessing cellulase activity is one of the causes of tunic softness syndrome in sea squirt.