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排序方式: 共有778条查询结果,搜索用时 11 毫秒
41.
42.
Laura Moss Derek Sleeman Malcolm Sim Malcolm Booth Malcolm Daniel Lyndsay Donaldson Charlotte Gilhooly Martin Hughes John Kinsella 《Knowledge》2010,23(4):309-315
Within the medical domain there are clear expectations as to how a patient should respond to treatments administered. When these responses are not observed it can be challenging for clinicians to understand the anomalous responses. The work reported here describes a tool which can detect anomalous patient responses to treatment and further suggest hypotheses to explain the anomaly. In order to develop this tool, we have undertaken a study to determine how Intensive Care Unit (ICU) clinicians identify anomalous patient responses; we then asked further clinicians to provide potential explanations for such anomalies. The high level reasoning deployed by the clinicians has been captured and generalised to form the procedural component of the ontology-driven tool. An evaluation has shown that the tool successfully reproduced the clinician’s hypotheses in the majority of cases. Finally, the paper concludes by describing planned extensions to this work. 相似文献
43.
This prospective study examined the predictive validity of the Structured Assessment of Violence Risk in Youth (SAVRY) and the Psychopathy Checklist: Youth Version (PCL: YV) in 99 male adolescents who were assessed in custody and followed up 12 months post release. Outcome data on recidivism were based on official Home Office records. The base rates for violent and general recidivism, respectively, were 38.4% and 70.7%. The predictive validity of the SAVRY Risk Total and the SAVRY Risk Rating was moderate for both violent and general recidivism, but both showed incremental validity in predicting outcomes compared with the PCL: YV. Data are discussed in relation to the limited published international literature. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
44.
This study examined associations among family type (same-sex vs. opposite-sex parents), adolescent gender, family and relationship variables, and the peer relations of adolescents. Participants included 44 adolescents parented by same-sex female couples and 44 adolescents parented by opposite-sex couples, matched on demographic characteristics and drawn from a national sample. On both self-reported and peer-reported measures of relations with peers, adolescents were functioning well, and the quality of their peer relations was not associated with family type. Regardless of family type, adolescents whose parents described closer relationships with them reported higher quality peer relations and more friends in school and were rated as more central in their friendship networks. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
45.
Cut order planning is the problem of planning the fabric cut for a set of apparel orders. A specified set of garments is ordered by the customer to be produced by a given date. Affiliated with this order is a set of garment sizes, and patterns for cutting each size. The fabric for cutting the order must be arranged on the cutting table in such a way as to minimize the cost of cutting the order. This plan must incorporate a partition of the pattern pieces to be arranged on top of the fabric layout. A mathematical model of the problem is developed and analyzed. On the basis of this analysis, solution approaches are developed that have been implemented on a desktop PC-based computer. Validated on representative industry problems, the approach is shown to be effective and versatile. 相似文献
46.
Charlotte T.M. Kwok Author VitaeAuthor Vitae Edmund G. Seebauer Author Vitae Author Vitae 《Automatica》2008,44(9):2241-2247
Self-diffusion in crystalline silicon is controlled by a network of elementary steps whose activation energies are important to know in a variety of applications in microelectronic fabrication. The present work employs maximum a posteriori (MAP) estimation to improve existing values for these activation energies, based on self-diffusion data collected at different values of the loss rates for interstitial atoms to the surface. Parameter sensitivity analysis shows that for high surface loss fluxes, the energy for exchange between an interstitial and the lattice plays the leading role in determining the shape of diffusion profiles. At low surface loss fluxes, the dissociation energy of large-atom clusters plays a more important role. Subsequent MAP analysis provides significantly improved values for these parameters. 相似文献
47.
Charlotte C. Appel Gianluigi A. Botton y Horsewell W. Michael Stobbs 《Journal of the American Ceramic Society》1999,82(2):429-435
Solid solution of manganese in yttria-stabilized zirconia (YSZ) may occur in the electrolyte of solid oxide fuel cells. Possible changes in valence, coordination, and site occupancy of Mn in YSZ are of interest. Also, subsequent structural modification of the cubic YSZ, as well as the possible ordering of vacancies, has important consequences for the ionic conductivity. Electron energy loss spectroscopy was used to measure the O K and the Mn L edge of Mn in solid solution in a zirconia host lattice. The ratio Mn L 3 / L 2 was determined for some manganese oxides and for Mn in solid solution. It is shown that the L 3 / L 2 ratio does not simply reflect the oxidation state of the Mn ions in solid solution. Selected area diffraction experiments were also made in the TEM. This showed ordering of the cations and the anion vacancies at high doping levels. It is concluded that the number of O ions surrounding each Mn ion may be very important in interpreting the obtained L 3 / L 2 ratio. 相似文献
48.
49.
Thioether Analogues of Disulfide‐Bridged Cyclic Peptides Targeting Death Receptor 5: Conformational Analysis,Dimerisation and Consequences for Receptor Activation
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Dr. Karolina Pulka‐Ziach Dr. Valeria Pavet Neila Chekkat Dr. Karine Estieu‐Gionnet Roman Rohac Dr. Marie‐Charlotte Lechner Dr. Cristian R. Smulski Dr. Gabrielle Zeder‐Lutz Dr. Danièle Altschuh Dr. Hinrich Gronemeyer Prof. Dr. Sylvie Fournel Dr. Benoit Odaert Dr. Gilles Guichard 《Chembiochem : a European journal of chemical biology》2015,16(2):293-301
Cyclic peptides containing redox‐stable thioether bridges might provide a useful alternative to disulfide‐bridged bioactive peptides. We report the effect of replacing the disulfide bridge with a lanthionine linkage in a 16‐mer cyclic peptide that binds to death receptor 5 (DR5, TRAIL‐R2). Upon covalent oligomerisation, the disulfide‐bridged peptide has previously shown similar behaviour to that of TNF‐related apoptosis inducing ligand (TRAIL), by selectively triggering the DR5 cell death pathway. The structural and biological properties of the DR5‐binding peptide and its desulfurised analogue were compared. Surface plasmon resonance (SPR) data suggest that these peptides bind DR5 with comparable affinities. The same holds true for dimeric versions of these peptides: the thioether is able to induce DR5‐mediated apoptosis of BJAB lymphoma and tumorigenic BJELR cells, albeit to a slightly lower extent compared to its disulfide homologue. NMR analysis revealed subtle variation in the conformations of the two peptides and suggests that the thioether peptide is slightly less folded than its disulfide homologue. These observations could account for the different capability of the two dimers to cluster DR5 receptors on the cell surface and to trigger apoptosis. Nevertheless, our results suggest that the thioether peptide is a potential candidate for evaluation in animal models. 相似文献
50.
Claus Crone Fuglsang Charlotte Johansen Stephan Christgau Jens Adler-Nissen 《Trends in Food Science & Technology》1995,6(12)
Antimicrobial enzymes are ubiquitous in nature, playing a significant role in the defense mechanisms of living organisms against infection by bacteria and fungi. Hydrolytic antimicrobial enzymes function by degrading key structural components of the cell walls of bacteria and/or fungi, whereas antimicrobial oxidoreductases exert their effects by the generation in situ of reactive molecules. The potential of these enzymes in food preservation is still far from realized at present. 相似文献