Clinical approach to the analysis of causes of death in the first two years of life of very-low-birthweight infants in a multicentre setting

Mortality in the first 2 years of 634 very-low-birthweight infants admitted to eight neonatal intensive care units in Italy, and the factors associated with the net probability of death from each cause, were studied by means of the Cox proportional hazard model. A clinical classification of the causes of death was used. Overall mortality was 33.7% (intercentre range 12.6-52.9%). The highest cause-specific mortality rates were observed for respiratory problems, intra-ventricular haemorrhage (IVH) and infections (14.5%, 6.3% and 5.7% respectively). The leading causes of death were respiratory problems and IVH in the first week of life, infections from the second week up to the end of the first month, and bronchopulmonary dysplasia (BPD) afterwards. Birthweight < 1000 g, gestational age < 30 weeks, absence of spontaneous respiratory activity, unknown body temperature and pH < 7.20 at admission were associated with death from respiratory problems and IVH. Male sex, birthweight < 1000 g and unknown body temperature at admission were associated with death from BPD. Mortality from infections was higher in one centre; no other differences emerged among the eight NICUs. The classification of the causes of death employed and the use of the net probabilities of death appear as practical and useful instruments to study the relationship between specific aspects of medical care and mortality, and to investigate the reasons for differences in performance between neonatal units.     

Speech perception, vocabulary, and the development of reading skills in english among Korean- and English-speaking children.

This study examined the roles of speech perception and phonological processing in reading and spelling acquisition for native and nonnative speakers of English in the 1st grade. The performance of 50 children (23 native English speakers and 27 native Korean speakers) was examined on tasks assessing reading and spelling, phonological processing, speech perception, and receptive vocabulary at the start and end of the school year. Korean-speaking children outperformed native English speakers on each of the literacy measures at the start and end of 1st grade, despite differences in their initial phonological representations and processing skills. Furthermore, speech perception and phonological processing were important contributors to early literacy skills, independent of oral language skills, for children from both language groups. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Mechanisms for the acquisition of situation awareness in situated agents

Situation awareness (SA) is the understanding required to operate a complex system in a highly dynamic environment. We evaluate theories of individual SA and the processes by which individuals maintain their understanding of a situation. We support a situated approach, which holds that individual operators make use of limited internal representation, and rely extensively on interactions with external props and tools to achieve and maintain SA. We also propose a synthesis of Durso et al. (2007) [Durso, F., Rawson, K., and Girotto, S., 2007. Comprehension and situation awareness. In: F. Durso, et al., eds. Handbook of applied cognition. 2nd ed. Hoboken, NJ: Wiley, 163–194.] Construction-Integration model of scene analysis with Sperber and Wilson's (1995) [Sperber, D. and Wilson, D., 1995. Relevance: communication and cognition. 2nd ed. Oxford: Blackwell.] Relevance Theory of comprehension. We show that the combination of the two theories can provide a more complete account of the mechanisms and processes underlying situation assessment, or sense-making, and is consistent with the situated approach to SA.     

Differential proteomics via probabilistic peptide identification scores

Relative quantitation is key to enable differential proteomics and hence answer biological questions by comparing samples. Classical approaches involve stable isotope labeling with/without spiked standards. Although stable isotopes may lead to precise results, their application is not straightforward. In Proteomics, 2004, 4, 2333-2351, we proposed an approach where we summed peptide identification scores to derive a semiquantitative abundance indicator. In this study, we combine such an indicator with a statistical test to detect differentially expressed proteins. We demonstrate the effectiveness of this method by using mixtures of purified proteins and human plasma spiked with proteins at low-nanomolar concentrations. The impact of the number of repeated experiments is discussed, and we show that the statistical test we use performs well with two to three repetitions, whereas a classical t-test would require at least four repetitions to achieve the same performance. Typically, 2.5-5-fold changes are detected with 90-95% confidence in human plasma. The method is finally characterized by deriving estimates of its false positive and negative rates. This new characterization is valid for a wider class of methods such as spectrum sampling (Liu, H.; Sadygov, R. G.; Yates, J. R. III. Anal. Chem. 2004, 76, 4193-4201).     

The motor intentional core of situation awareness

The situated approach to situation awareness (SA) claims that system operators often offload information instead of constructing detailed, stable and internal representations of dynamic situations. Offloading, which can be more or less deliberate, is the attenuation of internal processes in favor of augmenting external ones. Operators do this to minimise costly internal processing and storage. This paper uses empirical evidence and phenomenological analysis to argue that situated SA presupposes a motor intentional core. This core refers to embodied skills whose function is to present states of the system as being a certain way. They include, for example, the skillful eye scan patterns of experts and various epistemic actions that involve manipulating objects in the physical world to make information available to other cognitive processes. Through these motor intentional skills, offloaded information can be accessed on an as-needed basis. We discuss metrics for assessing the motor intentional core, as well as implications for interface design and the training of system operators, arguing that many motor intentional skills can be taught directly.     

Phonological awareness and reading acquisition in English- and Punjabi-speaking Canadian children.

This study examined whether the same component processes are involved in reading acquisition for native and nonnative speakers of English in the 1st grade. The performance of 88 children was examined on tasks assessing reading skill, phonological processing, and syntactic awareness. Fifty children were native English speakers (L1), and 38 children were from Punjabi-speaking families (ESL). Although measures of word recognition and phonological processing successfully discriminated between average and poor readers, they did not discriminate between the 2 language groups. Analyses of word reading errors revealed similar error patterns for ESL and L1 children, yet different error patterns for average and poor readers. For both L1 and ESL children, reading difficulties appear to be strongly linked with impaired phonological processing. (PsycINFO Database Record (c) 2010 APA, all rights reserved)