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排序方式: 共有1457条查询结果,搜索用时 15 毫秒
101.
Anna Schüller Daniel Matzner Dr. Christina E. Lünse Prof. Dr. Valentin Wittmann Dr. Catherine Schumacher Sandra Unsleber Prof. Dr. Heike Brötz‐Oesterhelt Prof. Dr. Christoph Mayer Prof. Dr. Gabriele Bierbaum Prof. Dr. Günter Mayer 《Chembiochem : a European journal of chemical biology》2017,18(5):435-440
The ever‐growing number of pathogenic bacteria resistant to treatment with antibiotics call for the development of novel compounds with as‐yet unexplored modes of action. Here, we demonstrate the in vivo antibacterial activity of carba‐α‐d ‐glucosamine (CGlcN). In this mode of action study, we provide evidence that CGlcN‐mediated growth inhibition is due to glmS ribozyme activation, and we demonstrate that CGlcN hijacks an endogenous activation pathway, hence utilizing a prodrug mechanism. This is the first report describing antibacterial activity mediated by activating the self‐cleaving properties of a ribozyme. Our results open the path towards a compound class with an entirely novel and distinct molecular mechanism. 相似文献
102.
Andreas Drakos Theofanis G. Orphanoudakis Christina Politi Alexandros Stavdas Andrew Lord 《Photonic Network Communications》2010,20(1):75-82
Clustering of nodes in optical networks has been proven to be an efficient way to serve end-to-end connectivity. However, clustering requires specific topological characteristics, or alternatively the introduction of significant alterations of an existing topology to achieve the expected performance improvements. The comparison of future dynamic optical networking technologies should therefore include in the set of initial assumptions, apart from the statistical properties of the traffic load, the network topology to draw conclusions regarding the efficiency as well as feasibility and scalability of the proposed solutions. In this article, we show how node clustering under the CANON architecture can be applied in real-life core networks and provide superior performance compared to conventional burst switching techniques in terms of blocking, resource utilization and power consumption. 相似文献
103.
Design of LTCC with High Thermal Expansion 总被引:1,自引:0,他引:1
Markus Eberstein Carsten Glitzky Marion Gemeinert Torsten Rabe Wolfgang A. Schiller Christina Modes 《International Journal of Applied Ceramic Technology》2009,6(1):1-8
New applications of low-temperature co-fired ceramics (LTCC), such as pressure sensors or integrated functional layers, require materials that possess higher coefficients of thermal expansion (CTE). To fabricate LTCC with elevated CTE, two methods of material design are examined: firstly, glass ceramic composites (GCC), which consist of >50 vol% glass in the starting powder, and, secondly, glass-bonded ceramics (GBC), where glass is added as a sintering aid only. The CTE of GBC is mainly determined by the crystalline component. For GCC, the CTE can be well predicted, if CTE and elastic data of each phase in the microstructure are known. A nonlinear characteristic of the CTE versus phase composition was found with increasing E crystals / E glass ratio and absolute CTE difference between the components. The glass composition and glass amount can be used to compensate the fixed properties of a crystalline material in a desired way. However, because the CTE and permittivity of a glass cannot be chosen independently, an optimum glass composition has to be found. For a given LTCC, it is possible to control the devitrification by shifting the glass composition. In this way, the resulting CTE values can be predicted more exactly and tailoring becomes possible. Different LTCC materials, based on the crystalline compounds Ba(La,Nd)2 Ti4 O12 , ZrO2 (Y-TZP), SiO2 (quartz), and specially developed glasses, possessing an elevated CTE of around 10 × 10−6 K−1 while showing permittivity ɛr between 6 and 63, are introduced. 相似文献
104.
P. Maguire, B. Devereux, F. Costello, and A. Cater (see record 2007-08734-012) discussed the Gagné and Shoben (1997) CARIN theory of conceptual combination and, after presenting a sample drawn from the British National Corpus and comparing the two corpora, concluded that the Gagné and Shoben corpus is too small and unrepresentative. They then discussed the mathematical model presented by Gagné and Shoben and claimed that the model does not incorporate relational competition. In this article, the authors present critical aspects of the mathematical model not considered by Maguire et al. and show that the mathematical instantiation of CARIN presented by Gagń and Shoben is, in fact, very sensitive to the number of strong competing relations. The authors then present some new comparisons between the corpora, showing that they correspond surprisingly well. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
105.
We present the transport unaware link improvement protocol (TULIP), which dramatically improves the performance of TCP over
lossy wireless links, without competing with or modifying the transport- or network-layer protocols. TULIP is tailored for
the half-duplex radio links available with today's commercial radios and provides a MAC acceleration feature applicable to
collision-avoidance MAC protocols (e.g., IEEE 802.11) to improve throughput. TULIP's timers rely on a maximum propagation
delay over the link, rather than performing a round-trip time estimate of the channel delay. The protocol does not require
a base station and keeps no TCP state. TULIP is exceptionally robust when bit error rates are high; it maintains high goodput,
i.e., only those packets which are in fact dropped on the wireless link are retransmitted and then only when necessary. The
performance of TULIP is compared against the performance of the Snoop protocol (a TCP-aware approach) and TCP without link-level
retransmission support. The results of simulation experiments using the actual code of the Snoop protocol show that TULIP
achieves higher throughput, lower packet delay, and smaller delay variance.
This revised version was published online in June 2006 with corrections to the Cover Date. 相似文献
106.
107.
Davidson Oranit B.; Eden Dov; Westman Mina; Cohen-Charash Yochi; Hammer Leslie B.; Kluger Avraham N.; Krausz Moshe; Maslach Christina; O'Driscoll Michael; Perrewé Pamela L.; Quick James Campbell; Rosenblatt Zehava; Spector Paul E. 《Canadian Metallurgical Quarterly》2010,95(5):953
A rigorous quasi-experiment tested the ameliorative effects of a sabbatical leave, a special case of respite from routine work. We hypothesized that (a) respite increases resource level and well-being and (b) individual differences and respite features moderate respite effects. A sample of 129 faculty members on sabbatical and 129 matched controls completed measures of resource gain, resource loss, and well-being before, during, and after the sabbatical. Among the sabbatees, resource loss declined and resource gain and well-being rose during the sabbatical. The comparison group showed no change. Moderation analysis revealed that those who reported higher respite self-efficacy and greater control, were more detached, had a more positive sabbatical experience, and spent their sabbatical outside their home country enjoyed more enhanced well-being than others. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
108.
109.
Skinner Darlene M.; Martin Gerard M.; Scanlon Christa-Jo; Thorpe Christina M.; Barry Jeremy; Evans John H.; Harley Carolyn W. 《Canadian Metallurgical Quarterly》2001,115(1):220
The ability of rats to return to the start location was examined with a 4-arm radial water maze. The task required rats to find 2 hidden platforms in sequence. Rats were released from 1 of 3 arms and there was a platform located in the fourth arm. Once a rat found this platform, a 2nd platform was raised in another location, which was either the start location, for 1 group, or another fixed location, for a control group. Across 3 experiments, all rats learned the location of the 1st fixed platform in 80 to 120 trials. However, rats had difficulty finding a 2nd platform if it was at the start location. Control groups revealed that rats could learn 2 platform locations and that the difficulty in learning to return to the start location did not seem to be attributable to its aversive nature. In separate groups, exposure to the start location was increased by starting the rats from an initially stable platform. Rats still did not readily learn to return to the start location. The authors suggest that start location, when varied, cannot readily be used to define the location of a hidden platform. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
110.
Maternal alcohol consumption during pregnancy places the fetus at risk for a number of neurological abnormalities and functional impairments. These deficits are 100% preventable by abstaining from alcohol use during pregnancy. Nevertheless, the worldwide prevalence of Fetal Alcohol Syndrome (FAS), the most severe outcome of prenatal alcohol consumption, is estimated at 0.97 cases per 1,000 live births (see May & Gossage, 2001). This paper examines awareness of the problem in Canada, the United States, the United Kingdom, and Australia along three dimensions: 1) the relationship between alcohol consumption rates and the incidence of FAS; 2) government action and policy creation; and 3) prevention/intervention initiatives and educational efforts. The extent of knowledge within each country affects, and is affected by, the level of research activity, the emphasis on policy creation, and the initiatives that drive educational efforts. At present, Canada and the U.S. have the highest levels of activity and a clear recognition of the problem. Activity in the U.K. and Australia is at the grass-roots level, although some promising movements toward greater public and professional awareness have begun. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献