基于软件无线电的GNSS干扰和多径监测系统设计

针对干扰和多径导致全球导航卫星系统(GNSS)不能精确、安全和可靠地提供位置、速度和时间服务等问题,分析了研制GNSS干扰和多径监测系统的意义,介绍了当前干扰和多径常用的检测方法,设计了一套针对当前四大导航系统(美国GPS、俄罗斯GLONASS、欧盟Galileo和中国BDS)各信号带内以及附近频率的干扰和多径监测系统.系统基于软件无线电(SDR)思想,采用模块化设计,具有良好的功能扩展性和配置灵活性.根据不同干扰的特点,结合实际应用改进了其检测算法:采用能量阈值法检测不同形式的压制式干扰,采用基于捕获多相关峰法判别欺骗式干扰,采取基于最大似然准则的多径估计延迟锁定环(MEDLL)技术估计多径信号的参数.实验结果表明系统能够有效检测各种干扰和多径信号的存在,使用户获取其特征参数,为干扰源的定位、查处、排除、规避以及多径信号的抑制提供决策依据.     

单倍型异基因造血干细胞-脐带间充质干细胞联合移植治疗1例急性白血病

目的研究急性粒细胞白血病异基因造血干细胞-人脐带源间充质干细胞（hUG—MSC）联合移植效果。方法急性髓性白血病-M2,供者为其胞兄,HLA单倍型相合,移植物为经粒细胞集落刺激因子（Granulocyte Clony—Stimulating Factor,G—CSF）动员的骨髓以及外周血造血干细胞,加入分离、扩增的hUC—MSC。移植物抗宿主病（Graft—Versus—Host Disease,GVHD）预防采用环孢菌素A＋ATG^＋霉酚酸酯＋短程甲氨喋呤和CD25单抗。结果输注供者的MSC总数和CD34细胞数分别为7．92×10^8/L和3．78×10^6／L。中性粒细胞大于0．5×10^9／L和血小板大于20×10^9／L的时间分别为14d和15d。24d嵌合体100％,40d左右出现Ⅰ度aGVHD,治疗后好转,未出现其他严重并发症。结论异基因造血干细胞-人脐带源间充质干细胞（hUC—MSC）联合移植安全简便,可加速造血功能恢复。     

Fortification of Bread with L-Lysine HCI: Losses Due to Baking Process

A Brasilian water bread was formulated with wheat flour (100%), salt (2%), yeast (5%), water (60%), fungal amylase (130 SKB/100g wheat flour), ascorbic acid (0.02%), and polysorbate-60 (1%). To the formulation was added Lysine.HCl at levels of 0.1, 0.2, 0.3, 0.4, and 0.5% as related to wheat flour in the formulation. The breads (fortified and control) were baked at 220°C for 20 min. The retention of lysine was estimated by measuring the free Lysine·HCl in bread with FDNB. A regression equation was developed relating the input and retention of lysine, which indicated a loss or destruction of 11.3% of added lysine during baking process.     

差动汇流环制造工艺与质量控制

汇流环装置作为雷达的一个有机组成部分,起着重要的作用.差动汇流环是汇流环中的一种特殊形式,它具有结构紧凑、轴向尺寸小、传递信号多等优点,因其传动系统为一差动轮系而得名,被广泛应用于各种车载、地面测控、舰载测控等雷达设备中.文中介绍了差动汇流环在制造工艺设计与质量控制方面,为保证其使用可靠性而采取的措施与实施要点.     

西藏地区需水量预测分析

通过对西藏水资源的现状分析,摸清了西藏水资源的基本状况。根据西藏地区过去分行业的用水情况及未来社会经济发展的预测,分析了西藏地区需水量预测的影响因素,应用灰色系统理论建立西藏地区需水预测模型,对西藏自治区2010年和2020年需水进行了预测分析,有助于西藏地区采取合理的用水规划措施,减少成本开支,促进西藏经济社会的可持续发展。2010～2020年,随着经济发展逐步进入稳定时期,社会总体科技水平将有较大发展,节水政策、节水技术和设施得到较好的实施,全社会用水水平也逐渐趋于平稳,年需水增长速度减缓,并逐步达到基本平稳,平均年递增率为1.5％。     

Drugs and immunity: cannabinoids and their role in decreased resistance to infectious disease

Marijuana, Cannabis sativa, elicits a variety of effects in experimental animals and humans. Delta-9-tetrahydrocannabinol (THC) is the major psychoactive component in marijuana. This substance has been shown, also, to be immunosuppressive and to decrease host resistance to bacterial, protozoan, and viral infections. Macrophages, T lymphocytes, and natural killer cells appear to be major targets of the immunosuppressive effects of THC. Definitive data which directly link marijuana use to increased susceptibility to infection in humans currently is unavailable. However, cumulative reports indicating that THC alters resistance to infection in vitro and in a variety of experimental animals support the hypothesis that a similar effect occurs in humans.     

Detection and characterization of the electron paramagnetic resonance-silent glutathionyl-5,5-dimethyl-1-pyrroline N-oxide adduct derived from redox cycling of phenoxyl radicals in model systems and HL-60 cells

Rapidly growing knowledge about the nature and behaviour of breast cancer has led to many treatment modalities. Consequently, the possibilities of individualizing the treatment of breast cancer increase. The major tool for the determination of an optimal treatment plan is the estimation of the extent of the disease: in other words, staging. As a consequence, together with the expected result of the treatment, the stage of the disease gives information on the prognosis of the patient. Current staging systems insufficiently describe the clinically important features of breast cancer with respect to management and outcome: local and regional extent, invasiveness, aggressiveness, the state of dissemination, and the effectiveness of different treatment modalities. For staging of the local and regional extent, histology plays a prominent role and should be incorporated in future staging systems. Histological workup therefore needs standardisation. Histological parameters as tumour size, grade, nodal status, and vascular invasion are also the most important prognostic factors. Many so-called biological prognostic factors are related to the invasiveness and aggressiveness (metastatic potential) of the tumour, and therefore to the prognosis of the patient. However, these factors do not necessarily predict the effectiveness of certain systemic treatments. Only if the biological foundation of a prognostic factor is completely clarified can treatment be based on this knowledge, and the factor will become a predictor for the treatment effect. Many "biological" prognostic factors do not fulfil this main criterion and are therefore not useful for clinical decision making. A clinically useful staging system covers three primary aims: (1) to guide locoregional treatment, (2) to prognosticate the chance of survival, and (3) to indicate who needs what kind of adjuvant treatment. For the conception of a new staging system the following steps should be taken: standardization of all aspects of histology, identification of regional nodal involvement, and validation of prognostic factors with respect to their predictive value to treatment outcome.     

Food allergy to peanuts in France--evaluation of 142 observations

BACKGROUND: The increase in frequency of peanut allergy and fatal cases have been reported. OBJECTIVES: The objective of this study is to document the severity of food allergy to peanuts by evaluating the reactive dose of peanuts and to search for the role of peanut oil. METHODS: This study is carried out on the basis of 142 observations collected according to the same diagnostic methodology in two allergy centres in France. Skin-prick-tests were performed with peanut powder, peanut oil and peanut oil proteinic extract. Labial provocation tests were performed on 121 patients. The reactive dose of peanuts and the role of peanut oil were determined by standardized oral provocation tests in 50 and 62 patients respectively. The data are computerized and the data bank includes 509 food allergic patients. RESULTS: Allergy to peanuts represents 28% of food allergies and occurs under 1 year of age in 46% of cases, under 15 years of age in 93%. The clinical features were atopic dermatitis (40%), angioedema (37%), asthma (14%), anaphylactic shock (6%) and digestive symptoms (1.4%). The specific IgE were class 3 or higher in 80% of cases. The total reactive dose was less than 100 mg in 25% of cases, from 100 mg to 1 g in 62.5%. All patients reacted to a dose of less than 7.1 g. The threshold of peanut reactivity was lower than the threshold of egg reactivity. An allergy to peanut oil was demonstrated in 14 patients. CONCLUSION: The severity of peanut allergy and the early onset of the occurrence of this allergy is documented. The role of residual allergenic proteins in peanut oil is established by positive skin-prick tests to proteic extracts from peanut oil and by double-blind placebo-controlled challenges to peanut oil. The increased consumption of allergens in the form of peanut oil and fats can contribute to the occurrence or persistence of symptoms and may be suspected to increase the risk of sensitisation.     

Efficient lymphocyte migration across high endothelial venules of mouse Peyer's patches requires overlapping expression of L-selectin and beta7 integrin

Lymphocyte migration into lymphoid organs is regulated by adhesion molecules including L-selectin and the beta7 integrins. L-selectin and alpha4beta7 are predominantly hypothesized to direct the selective migration of lymphocytes to peripheral lymph nodes and the gut-associated lymphoid tissues, respectively. To further characterize interactions between L-selectin and beta7 integrins during lymphocyte recirculation, mice deficient in both receptors (L-selectin/beta7 integrin-/-) were generated. The simultaneous loss of L-selectin and beta7 integrin expression prevented the majority of lymphocytes (>95% inhibition) from attaching to high endothelial venules (HEV) of Peyer's patches and other lymphoid tissues during in vitro binding assays. Moreover, the inability to bind HEV eliminated the vast majority of L-selectin/beta7 integrin-/- lymphocyte migration into Peyer's patches during short-term and long-term in vivo migration assays (>99% inhibition,p < 0.01). The lack of lymphocyte migration into Peyer's patches correlated directly with the dramatically reduced size and cellularity (99% reduced) of this tissue in L-selectin/beta7 integrin-/- mice. High numbers of injected L-selectin/beta7 integrin-/- lymphocytes remaining in the blood of wild-type mice correlated with markedly increased numbers of circulating lymphocytes in L-selectin/beta7 integrin-/- mice. Loss of either L-selectin or the beta7 integrins alone resulted in significant but incomplete inhibition of Peyer's patch migration. Collectively, the phenotype of L-selectin/beta7 integrin-/- mice demonstrates that these two receptors primarily interact along the same adhesion pathway that is required for the vast majority of lymphocyte migration into Peyer's patches.