物流企业实施ISO9001:2000咨询效果分析

通过对中国物流行业发展现状的分析，对国内物流企业如何整合物流资产、物流业务、物流信息、物流人才以及整合物流企业进行了探讨。对物流企业建立、健全适合自身发展的管理机制和服务体系提出了建议。以期物流企业提高服务质量和管理水平，真正实现与国际规则接轨。     

大时滞系统的智能控制研究

在实际控制应用中常常有大时滞存在，用传统控制方法较难获得满意的控制效果。为解决这个问题，该文提出了基于模糊神经网络控制器，模拟手动控制过程，根据过程状态的动态变化实施控制器的在线调整，仿真和实践结果均表明了该控制方案的优越性。     

基于物理层信息加密的卫星隐蔽通信研究

为了增强卫星通信信号的隐蔽性和安全性,提出一种基于物理层信息加密的加权分数傅里叶变换（WFRFT）调制方式。结合WFRFT的低概率截获特性以及无线信道状态信息（CSI）的动态唯一性,在WFRFT系统中构造一个具有加密性质的酉矩阵,克服了传统WFRFT方法的不足,增加了信号处理的多样性。加密酉矩阵的生成利用了卫星通信系统的物理层信道特征,合法通信双方通过约定方式将合法信道的CSI转化为相位旋转因子,并以此为密钥完成对传输信号的加密和解调。仿真结果表明,经酉矩阵加密后的卫星信号在保持原WFRFT信号统计特性的基础上具有更复杂的星座分布,窃听者的误码率始终保持在0.5左右,有效保证了信息的安全传输。     

The cortisol response to psychological stress in temporomandibular dysfunction

Recombinant antibody fragments can be produced in large quantities using bacterial expression systems and could potentially be useful for the generation of biofilters for the selective removal of viral particles from fluids. A human single chain-Fv antibody library, derived from synthetic repertoires of germ line VH-gene segments rearranged in vitro and paired to a single light chain (Nissim et al., 1994, EMBO J., 13, 692-698), has recently been used to isolate hundreds of different binding specificities by panning with antigen. Antibodies from this library typically have affinities in the 10(6)-10(7) M-1 range. Occasionally, better binders are isolated but at other times the affinities recovered are poor. In the latter situation binding cannot be detected with soluble antibodies, but only by high-avidity display of multiple copies of antibodies on phage. By panning with human cytomegalovirus (HCMV)-coated immunotubes, we have isolated a number of antibody clones from this library that bound to the antigen only if displayed on the filamentous phage, but not in soluble form. One of these clones was selected for an affinity maturation procedure, achieved by combinatorial mutagenesis of the complementarity determining region 3 (CDR3) of the antibody light chain, followed by selection of the resulting library for HCMV binding. By this means, we were able to isolate a number of binders, some of which exhibited specific HCMV binding in soluble form. The clone that gave the strongest ELISA signal was expressed in bacteria, purified in solution, characterised using a novel capture methodology with surface plasmon resonance detection on a BIAcore instrument and used for the production of an immunofilter for the removal of HCMV form human serum. The filter removed more than 99% of applied HCMV in 10 min circulation time, while the amount of HCMV retained non-specifically in a cartridge derivatised with a non-specific antibody was less than 10% under similar conditions.     

Microbiologic contamination during dental radiographic film processing

Arteriosclerotic intimal proliferation is one of the main long-term complications of organ transplantation. Low-molecular-weight, heparin-like molecules prevent myointimal proliferation in arterial wall injury and limit rejection in skin allografts. Cyclosporin limits rejection but has no major effect on intimal proliferation. Therefore, an experimental protocol was designed to test whether heparin-like molecules interacted with low doses of cyclosporin to prevent arterial wall immune system injury and response in a model of arterial graft rejection in normotensive and hypertensive rats. Aortic allografts were performed in spontaneously hypertensive rats (SHRs) and Wistar-Kyoto (WKY) normotensive control rats. Four groups of 10 allografted (SHR and WKY) rats were used: one group was treated with placebo, one with low doses of cyclosporin (2 mg/kg body wt per day), one with low-molecular-weight, heparin-like molecule (1 mg/kg body wt per hour), and one with low doses of cyclosporin plus low-molecular-weight, heparin-like molecule. Ten SHRs and 10 WKYs were isografted and served as the control groups. All rats were killed 8 weeks after aortic grafting. Structural parameters of the grafted segment were measured by morphometric analysis on formalin-fixed sections with specific stains. The classical signs of immune system injury and response were present in the untreated allografts in SHRs and WKYs: inflammatory infiltration of the adventitia, medial injury, and intimal proliferative response. Low doses of cyclosporin had a significant beneficial effect on immune medial injury by increasing medial thickness and the number of remaining smooth muscle cells and decreasing the extracellular matrix injury. Cyclosporin had no protective effect on intimal proliferation.(ABSTRACT TRUNCATED AT 250 WORDS)     

Functional nucleotide excision repair is required for the preferential removal of N-ethylpurines from the transcribed strand of the dihydrofolate reductase gene of Chinese hamster ovary cells

Cervid species represent a growing livestock enterprise in the United States of America (USA). The zoonotic threat of bovine tuberculosis (Mycobacterium bovis) is the only significant public health risk posed by this alternative livestock industry. This paper examines the potential sources of tuberculosis exposure as related to public health and compares and contrasts the status of tuberculosis in Cervidae with the situation in the cattle industry in the USA. Based on the existing prevalence of the disease and the limited potential of human exposure to infected meat or meat products, bovine tuberculosis in Cervidae poses a minimal threat to public health. The only significant public health concern is exposure to infected free-ranging cervids of hunters who field-dress carcasses and may unknowingly incise tuberculous lesions. This risk is mitigated only by the small size of the cervid population at risk when compared to the general population of cervids hunted yearly.     

基于直流电抗电压的柔性直流配电网故障测距方法

故障测距是柔性直流配电网发展所需的关键技术之一,传统的高压直流输电系统故障测距方法在直流配电系统中适应性不好。因此在考虑线路配置直流电抗器的情况下,提出一种基于直流电抗电压的直流配电网双端故障测距方法。该方法从直流故障的电容放电阶段进行研究,利用线路两端直流电抗电压构建包含故障距离和过渡电阻的两个未知参数的时域微分方程,并利用最小二乘法进行求解。PSCAD仿真结果表明该方法能够有效地进行故障定位,并且能够计算出故障点过渡电阻,可以满足直流配电网的故障测距要求。     

Criterion validity and the utility of reactive and proactive aggression: comparisons to attention deficit hyperactivity disorder, oppositional defiant disorder, conduct disorder, and other measures of functioning

Human immunodeficiency virus (HIV)-associated nephropathy (HIVAN) is a clinicopathologic entity that includes proteinuria, azotemia, focal segmental glomerulosclerosis or mesangial hyperplasia, and tubulointerstitial disease. The incidence of HIVAN is increased in black patients and variable depending on the age and geographic area. The objective of this study was to describe relevant clinical and pathological findings in 30 children with HIVAN followed at the Children's National Medical Center in Washington, D.C. Our experience of the last 12 years showed a spectrum of HIVAN that seems to be coincident with the degree of acquired immunodeficiency syndrome (AIDS) symptomatology. By renal sonograms and frequent urinalysis, we identified children undergoing the early stages of HIVAN with enlarged echogenic kidneys, proteinuria, and "urine microcysts". HIVAN did not necessarily progress rapidly to end-stage renal disease. Nephrotic syndrome or chronic renal insufficiency were late manifestations of HIVAN. Children with HIVAN were likely to develop transient electrolyte disorders, heavy proteinuria, and acute renal failure due to systemic infectious episodes or nephrotoxic drugs. HIVAN was associated with other HIV-induced illnesses and high mortality rates. Early detection and careful clinical follow-up of children with HIVAN may reduce the incidence of renal-cardiovascular complications and improve their quality of life.     

收发频谱不一致条件下的变换域通信系统基函数设计

针对变换域通信系统收发频谱不一致条件下接收端基函数存在错误而导致系统性能下降的问题,提出了具有信噪比次优解的基函数设计方法。详细分析了系统的收发过程,在此基础上研究了系统误码率的最优化与接收端基函数组成的关系,在收发频谱不一致而无法获得最优基函数的情况下,采用类似等增益合并的方法设计了接收端基函数,从而以该基函数完成数据解调。仿真结果表明:在单用户和多用户环境下,当收发频谱不一致比例较高时,接收端采用类似等增益合并的基函数设计方法可以完成系统的次优接收。在单用户环境下,相比不一致比例为40%时,次优接收方法的信噪比增益可达4dB左右,并且发送端频谱可用率为80%时,相比最优接收法的信噪比损失在1.5dB以内。     

星用光纤通信系统中的发光二极管的总剂量效应研究

介绍了星用光纤通信系统中的发光二极管在 6 0 Co- γ射线辐照下的总剂量效应试验研究 ,通过对不同剂量辐照情况下发光二极管的发光光谱、伏安特性及 P- I曲线进行测试 ,给出了在不同剂量的 γ- 6 0 Co射线辐照下发光二极管的发光光谱、伏安特性及 P- I曲线