全文获取类型
收费全文 | 1885篇 |
免费 | 18篇 |
国内免费 | 1篇 |
专业分类
电工技术 | 8篇 |
综合类 | 1篇 |
化学工业 | 146篇 |
金属工艺 | 30篇 |
机械仪表 | 20篇 |
建筑科学 | 9篇 |
能源动力 | 16篇 |
轻工业 | 32篇 |
石油天然气 | 1篇 |
无线电 | 68篇 |
一般工业技术 | 171篇 |
冶金工业 | 1330篇 |
原子能技术 | 3篇 |
自动化技术 | 69篇 |
出版年
2022年 | 4篇 |
2021年 | 17篇 |
2020年 | 7篇 |
2019年 | 5篇 |
2018年 | 10篇 |
2017年 | 7篇 |
2016年 | 18篇 |
2015年 | 11篇 |
2014年 | 14篇 |
2013年 | 35篇 |
2012年 | 22篇 |
2011年 | 24篇 |
2010年 | 20篇 |
2009年 | 23篇 |
2008年 | 16篇 |
2007年 | 24篇 |
2006年 | 21篇 |
2005年 | 21篇 |
2004年 | 16篇 |
2003年 | 24篇 |
2002年 | 18篇 |
2001年 | 11篇 |
2000年 | 12篇 |
1999年 | 51篇 |
1998年 | 430篇 |
1997年 | 226篇 |
1996年 | 141篇 |
1995年 | 94篇 |
1994年 | 75篇 |
1993年 | 94篇 |
1992年 | 24篇 |
1991年 | 21篇 |
1990年 | 23篇 |
1989年 | 30篇 |
1988年 | 27篇 |
1987年 | 36篇 |
1986年 | 18篇 |
1985年 | 21篇 |
1984年 | 12篇 |
1983年 | 15篇 |
1982年 | 11篇 |
1981年 | 11篇 |
1980年 | 16篇 |
1978年 | 4篇 |
1977年 | 42篇 |
1976年 | 65篇 |
1975年 | 4篇 |
1973年 | 6篇 |
1972年 | 5篇 |
1970年 | 5篇 |
排序方式: 共有1904条查询结果,搜索用时 15 毫秒
51.
Chirag Desai 《Drug development and industrial pharmacy》2015,41(10):1589-1607
Context: The clinical applications of cilostazol (CLZ) are limited by its low aqueous solubility (<5?µg/ml) and high biovariability.Objective: The aim of this study was to enhance the solubility of CLZ by forming inclusion complexes (ICs) with beta cyclodextrin (β-CD) and formulating them into oral disintegrating tablets.Methods: Phase solubility study of CLZ with β-CD was performed in water. Job’s plot was constructed to determine the stoichiometry of ICs. ICs, prepared by spray-drying technique, were characterized using Fourier transform infrared spectroscopy, differential scanning calorimetry, hot stage microscopy, powder X-ray diffraction and nuclear magnetic resonance. Molecular modeling studies were performed to understand the mode of interaction of CLZ with β-CD. The formulation process was undertaken using a reproducible design of experiment generated model, attained by variation of diluents and disintegrants at three levels. Tablets were evaluated for drug content, hardness, friability, disintegration time (DT), wetting time (WT) and dissolution profiles.Results and discussion: Phase solubility studies suggested an AL type curve with stability constant (Ks) of 922.52?M?1. Job’s plot revealed 1:2 stoichiometry. All analytical techniques confirmed inclusion complexation. Molecular modeling revealed dispersive van der Waals interaction energy as a major contributor for stabilization of complex. The spray-dried complexes showed higher solubility and faster dissolution compared to plain CLZ. The optimized formulation showed DT of 11.1?±?0.8?s, WT of 8.7?±?0.9?s and almost complete dissolution of CLZ in 15?min.Conclusion: The prepared tablets with low DT and fast dissolution will prove to be a promising drug delivery system with improved bioavailability and better patient compliance. 相似文献
52.
53.
Janish Desai Dr. Yang Wang Dr. Ke Wang Dr. Satish R. Malwal Prof. Eric Oldfield 《ChemMedChem》2016,11(19):2205-2215
We synthesized potential inhibitors of farnesyl diphosphate synthase (FPPS), undecaprenyl diphosphate synthase (UPPS), or undecaprenyl diphosphate phosphatase (UPPP), and tested them in bacterial cell growth and enzyme inhibition assays. The most active compounds were found to be bisphosphonates with electron‐withdrawing aryl‐alkyl side chains which inhibited the growth of Gram‐negative bacteria (Acinetobacter baumannii, Klebsiella pneumoniae, Escherichia coli, and Pseudomonas aeruginosa) at ~1–4 μg mL?1 levels. They were found to be potent inhibitors of FPPS; cell growth was partially “rescued” by the addition of farnesol or overexpression of FPPS, and there was synergistic activity with known isoprenoid biosynthesis pathway inhibitors. Lipophilic hydroxyalkyl phosphonic acids inhibited UPPS and UPPP at micromolar levels; they were active (~2–6 μg mL?1) against Gram‐positive but not Gram‐negative organisms, and again exhibited synergistic activity with cell wall biosynthesis inhibitors, but only indifferent effects with other inhibitors. The results are of interest because they describe novel inhibitors of FPPS, UPPS, and UPPP with cell growth inhibitory activities as low as ~1–2 μg mL?1. 相似文献
54.
55.
In processes, such as melt spinning, the crystallization behavior of syndiotactic polypropylene (sPP) is found to be substantially different from that of most other linear polymers. The anisotropic stress field in such processes leads invariably to extension as well as alignment (orientation) of the chains in the melt, both of which contribute usually to dramatic enhancement in the rate of crystallization. However, since the primary structure of the sPP chain in its most preferred crystal form is comprised of a “coiled helical,” ? (T2G2)2? , sequence, stress‐induced chain extension can lead to conformational sequences that are not favorable for crystallization in this form. As a consequence, process conditions that generate higher stress levels can cause a diminution in the rate of crystallization of this polymer. Such conformation‐related aspects of oriented crystallization of sPP have been addressed through an analysis of the structure and properties of melt‐spun fibers, produced over a range of spinning speeds. The results serve to identify a refinement that is needed in current models of oriented crystallization and also a mechanism to promote the nucleation of crystallization of sPP. © 2001 John Wiley & Sons, Inc. J Appl Polym Sci 81: 2305–2317, 2001 相似文献
56.
Sachin D. Kore P. P. Date S. V. Kulkarni Satendra Kumar Dolly Rani M. R. Kulkarni S. V. Desai R. K. Rajawat K. V. Nagesh D. P. Chakravarty 《The International Journal of Advanced Manufacturing Technology》2011,54(9-12):949-955
The ability to manufacture a product using different metal combinations greatly increases flexibility in design and production. Joining of dissimilar metal combinations like Copper-to-Stainless Steel (Cu-to-SS) is, however, a challenging task owing to the large differences in physical and chemical properties. The application of electromagnetic (EM) impact technique is demonstrated for welding copper (Cu) to stainless steel (SS) sheets. The welding Cu-to-SS is accomplished by using Al drivers to accelerate Cu and SS work sheets. The tensile shear strength test and the metallographic studies are carried out for Cu-to-SS EM welds. 相似文献
57.
58.
DD Lund FM Faraci H Ooboshi BL Davidson DD Heistad 《Canadian Metallurgical Quarterly》1999,30(1):120-125
OBJECTIVE: Regional presynaptic dopaminergic function and its regulation by dopamine agonists in different stages of PD can be measured by L-[11C]dopa and PET. In the current investigation, we studied the effects of therapeutic apomorphine on L-[11C]dopa uptake in patients with early and advanced PD. BACKGROUND: With disease progression and chronic dopamine agonist treatment, motor response complications supervene in a majority of PD patients. It is assumed that both presynaptic and postsynaptic changes in the dopaminergic system act to modify dopaminergic efficacy. METHODS: Patients with early and advanced stages of PD were included in the study. All patients were investigated twice with PET and L-[11C]dopa drug free and during a subsequent standardized therapeutic apomorphine infusion. RESULTS: Subregional analysis of the striatum showed differences in the effects of apomorphine infusion on the L-[11C]dopa influx rate in the two patient categories. In patients with early and uncomplicated PD, apomorphine infusion decreased the L-[11C]dopa influx rate. This decrease was most pronounced in the dorsal part of the putamen. In advanced PD patients, apomorphine did not affect the striatal L-[11C]dopa influx rate. CONCLUSIONS: We suggest that in mild and stable PD an upregulated presynaptic inhibitory feedback regulation, particularly in the dorsal putamen, acts to maintain congruity within the dopaminergic system in response to antiparkinsonian medication. However, this inhibitory feedback regulation is diminished with the progression of nigrostriatal degeneration and chronic dopamine agonist treatment. 相似文献
59.
The ability of biomaterial surfaces to regulate cell behavior requires control over surface chemistry and material microstructure. One of the goals in the development of silicon-based biomedical devices such as biosensors or drug delivery systems is improved biocompatibility which may be achieved through the deposition or adsorption of thin films. In this study, films of single crystal silicon, stoichiometric and low stress silicon nitride, doped and undoped polysilicon, as well as Arg-Gly-Asp (RGD) peptide adsorbed surfaces characterized in terms of protein adsorption or cellular adhesion for a period of four days. Protein adsorption studies using fibrinogen and albumin, two proteins implicated in cellular adhesion and surface activity, reveal that low stress silicon nitride surfaces have a 223%±2.50% greater protein adsorption compared to undoped polysilicon surfaces, followed by silicon nitride, unmodified silicon, and doped polysilicon surfaces, respectively. The thickness of the adsorbed albumin and fibrinogen layer on various thin films was measured by ellipsometry and compared to contact angle measurements. The greatest cellular adhesion was observed on undoped polysilicon, followed by unmodified (control) silicon, low stress silicon nitride, silicon nitride, and doped polysilicon surfaces. Cellular binding supports the differential protein adsorption found on modified and unmodified silicon surfaces. Understanding the biological response to thin films will allow us to design more appropriate interfaces for implantable diagnostic and therapeutic silicon-based microdevices. 相似文献
60.
This work describes a solid-phase immunoassay for 6-keto-prostaglandin F1alpha, the stable hydrolysis product of prostacyclin (prostaglandin I2). Prostacyclin, a potent vasodilator with antiplatelet and antiproliferative properties is an effective treatment for primary pulmonary hypertension and pulmonary arterial hypertension associated with scleroderma and scleroderma-like syndrome. Levels of 6-keto-prostaglandin F1alpha can be directly correlated with levels of prostacyclin. Therefore, 6-keto-prostaglandin F1alpha, has become the indicator of choice to measure prostacyclin levels. The single-step immunoassay for 6-keto-prostaglandin F1alpha reported here was developed using the bioluminescent protein aequorin as a label. Analyte-label conjugates were constructed by linking the carboxyl group of 6-keto-prostaglandin F1alpha and lysine residues of aequorin by chemical conjugation methods. The binding properties of 6-keto-prostaglandin F1alpha toward its antibody and the bioluminescent properties of aequorin were retained in the conjugate, which was then used to generate a dose-response curve for the analyte in a convenient microtiter plate format. The concentration of 6-keto-prostaglandin F1alpha after extraction from plasma showed good correlation with the concentration of 6-ketoprostaglandin F1alpha obtained without prior extraction of the same plasma sample. This measurement demonstrated that the assay allows the measurement of 6-keto-prostaglandin F1alpha directly in plasma without any pretreatment of the samples, which results in a much simpler method with a faster assay time. 相似文献