Electromechanical Behavior of Al/Al2O3 Multilayers on Flexible Substrates: Insights from In Situ Film Stress and Resistance Measurements

A series of Al and Al/Al₂O₃ thin-film multilayer structures on flexible polymer substrates are fabricated with a unique deposition chamber combining magnetron sputtering (Al) and atomic layer deposition (ALD, Al₂O₃, nominal thickness 2.4–9.4 nm) without breaking vacuum and thoroughly characterized using transmission electron microscopy (TEM). The electromechanical behavior of the multilayers and Al reference films is investigated in tension with in situ X-ray diffraction (XRD) and four-point probe resistance measurements. All films exhibit excellent interfacial adhesion, with no delamination in the investigated strain range (12%). For the first time, an adhesion-promoting naturally forming amorphous interlayer is confirmed for thin films sputter deposited onto polymers under laboratory conditions. The evolution of Al film stresses and electrical resistance reveal changes in the deformation behavior as a function of oxide thickness. Strengthening of Al is observed with increasing oxide thickness. Significant embrittlement can be avoided for oxide layer thicknesses ≤2.4 nm.     

DNA-oligonucleotide encapsulating liposomes as a secondary signal amplification means

A novel liposome-based signal amplification system was developed by encapsulating DNA oligonucleotides within antibody-tagged liposomes and subsequently detecting the oligonucleotide with dye-encapsulating liposomes for double signal enhancement. In this sandwich immunoassay, the model analyte, protective antigen protein from B. anthracis, was captured by one set of antibodies immobilized in microtiter plate wells and detected using a second antibody conjugated to oligonucleotide-encapsulating liposomes. Bound liposomes were lysed releasing the encapsulated fluorescein-tagged DNA 25-mer probe, which was then permitted to hybridize with its complementary sequence immobilized in a second plate. Finally, the amount of oligonucleotide was detected through the addition of anti-fluorescein antibody tagged dye-encapsulating liposomes. These secondary liposomes allowed for a approximately 400x lower LOD than detection of the fluorescein-labeled probe alone. Several aspects were investigated, including the encapsulation of various oligonucleotide concentrations within liposomes; oligonucleotide hybridization times and buffers; degree of anti-fluorescein antibody coverage on the liposomes; and immobilized anti-protective antigen antibody concentration. We found that the encapsulation efficiency increased with the starting oligonucleotide concentration. As many as 4000 DNA 25-mers were successfully entrapped in the liposome, and minimal leakage was observed over the course of 8 months. When used in the sandwich immunoassay, a limit of detection of 4.1 ng/mL protective antigen was observed with an upper limit of 5000 ng/mL. Due to the endless combination of DNA oligonucleotide sequences, this assay lends itself perfectly for multiplexing on the order of tens to hundreds of analytes.     

Weld residual stress effects on fatigue crack growth behaviour of aluminium alloy 2024-T351

The interaction between residual stress and fatigue crack growth rate has been investigated in middle tension and compact tension specimens machined from a variable polarity plasma arc welded aluminium alloy 2024-T351 plate. The specimens were tested at three levels of applied constant stress intensity factor range. Crack closure was continuously monitored using an eddy current transducer and the residual stresses were measured with neutron diffraction. The effect of the residual stresses on the fatigue crack behaviour was modelled for both specimen geometries using two approaches: a crack closure approach where the effective stress intensity factor was computed; and a residual stress approach where the effect of the residual stresses on the stress ratio was considered. Good correlation between the experimental results and the predictions were found for the effective stress intensity factor approach at a high stress intensity factor range whereas the residual stress approach yielded good predictions at low and moderate stress intensity factor ranges. In particular, the residual stresses accelerated the fatigue crack growth rate in the middle tension specimen whereas they decelerated the growth rate in the compact tension sample, demonstrating the importance of accurately evaluating the residual stresses in welded specimens which will be used to produce damage tolerance design data.     

Effect of tool profile and fatigue loading on the local hardness around scratches in clad and unclad aluminium alloy 2024

Nanoindentation has been used to study the hardness changes produced by scratching of aluminium alloy AA2024, with and without a clad layer of pure aluminium. The hardness was mapped around scratches made with diamond tools of different profiles. One tool produced significant plastic damage with associated hardening at the scratch root, whilst the other produced a ‘cleaner’ cut with no hardening. The different behaviours are attributed to whether the tool makes the scratch by a ‘cutting’ or a ‘ploughing’ mechanism. The degree of plastic damage around the scratches has been correlated with peak broadening data obtained using synchrotron X-ray diffraction.There was no change observed in the local hardness around the scratch with fatigue loading.     

异步片上网络研究综述

异步片上网络具有低动态功耗、对延迟抖动的不敏感、统一的网络接口、较低的系统集成复杂度和较好的电磁兼容能力等众多特性,是下一代片上多核微处理器和多核片上系统的标准片上通信架构之一.在简单介绍异步电路的相关理论后,从多个方面概述了当前异步片上网络的研究成果,包括网络拓扑、同步?异步接口、流控制、服务质量、路由算法、低功耗设计、容错和可测性设计以及设计自动化;然后介绍并分析了一些具有代表性的异步片上网络设计案例.研究显示,异步片上网络具有众多同步片上网络所不具备的优点,大量的片上多核系统将使用异步片上网络作为其片上通信系统,但它们的易用性和网络性能亟待提高.     

Coarse-to-fine adaptive masks for appearance matching of occluded scenes

In this paper, we discuss an appearance-matching approach to the difficult problem of interpreting color scenes containing occluded objects. We have explored the use of an iterative, coarse-to-fine sum-squared-error method that uses information from hypothesized occlusion events to perform run-time modification of scene-to-template similarity measures. These adjustments are performed by using a binary mask to adaptively exclude regions of the template image from the squared-error computation. At each iteration higher resolution scene data as well as information derived from the occluding interactions between multiple object hypotheses are used to adjust these masks. We present results which demonstrate that such a technique is reasonably robust over a large database of color test scenes containing objects at a variety of scales, and tolerates minor 3D object rotations and global illumination variations. Received: 21 November 1996 / Accepted: 14 October 1997     

Computer assisted education in health economics for medical advisers

A computer-based distance learning study aid on health economics (HELP) for medical advisers was developed from an existing paper course using a user-centred, prototyping approach. We illustrate and discuss this approach. The prototypes were iteratively tested and refined with potential users. The initial prototype was used for market research which included a survey of medical and pharmaceutical advisers. Results from the market research established the study aid's feasibility. The design of the study aid was guided by the market research and by application of an architectural analysis and design framework. HELP was designed in the form of an electronic, frame-based book with self-tests and navigational facilities that permit additional exploration. On-line journal articles were included for users' reference. The strategy adopted for delivery of the new course consists of presenting the computer study aid together with the paper course. The authoring shell that was developed is generically reusable for other courses with other teaching and learning strategies.     

Detection of river/sea ice deformation using satellite interferometry: limits and potential

In this paper, we present a study consisting of the application of radar interferometry for river/sea ice monitoring in inhabited regions and on commercial waterways. The sites studied are located in Canadian regions where ice jams constitute a common winter hazard that can cause extensive socio-economic damage and impose severe restrictions on ship traffic. ERS and Radarsat images were jointly used with traditional in situ observations to detect ice break-up in order to prevent ice jams and related problems. A coherence study served to define the synthetic aperture radar interferometry (InSAR) limits for river/sea ice dynamics monitoring. Other factors that also help to define the limits of InSAR technology for this application include the frequency of image acquisition, the minimum dimension of detected ice floes and the determination of appropriate ice types. Significant phase shifts were found for small ice floes of several hundred metres with ERS-tandem images. The analysis of the interferograms showed that it is possible to detect deformations in the ice shelf and to discriminate quantitatively the horizontal and vertical components of ice movement when the interferograms are combined with traditional observations such as meteorological data, water level, water flow and ice charts. The deformation estimated on a piece of fast river ice can be interpreted as the first sign of the ice break-up. On an estuary river that is a busy seaway, a qualitative interpretation of the interferograms served to highlight the interaction of river and tidal flows affecting the ice cover. We showed, in particular, the potential of radar interferometry and its integration with other techniques to help the authorities to prevent problems related to ice jams.     

An algorithm for the inference of tree grammars

An algorithm for the inference of tree grammars from sample trees is presented. The procedure, which is based on the properties of self-embedding and regularity, produces a reduced tree grammar capable of generating all the samples used in the inference process as well as other trees similar in structure. The characteristics of the algorithm are illustrated by experimental results.Work supported by the Office of Naval Research, Arlington, Virginia, under contract N00014-71-A-0121-0005.     

The influence of the process characteristics on the role of the human operator in process control

Rational design of a process control system using an on-line computer requires a definition of the total control task and an allocation of function between the human operator and the machine. Both the nature of the total task and its subdivision depend very much on the process characteristics, which vary widely between different processes. The functions normally performed by a process control computer are described and those consequently left to the operator are defined. The wide variety of the operator's functions and the implications of this for studies of the operator's performance and for the design of the man-machine interface are emphasised. This article was originally presented as a paper at a symposium on Data Reduction, Communication and Presentation for Process Operation organised by the Institute of Measurement and Control at the University of Sussex, Brighton.