Point/Counterpoint

POINT: AOP Will See Widespread Adoption Adrian Colyer, Rob Harrop, Rod Johnson, and Alexandre Vasseur AOP offers both the short--and long-term return on investment needed to ensure its widespread adoption. COUNTERPOINT: AOP Has Yet to Prove Its Value Danio Beuche and Cédric Beust Where is the proof that nonhierarchical modularization into aspects makes systems development cheaper or better?     

Spray cooling effects on milk production, milk, and rectal temperatures of cows during a moderate temperate summer season

During summer 1982, responses of lactating Holstein and Guernsey cows were measured by milk temperature recorded by a Digital Dataloger with thermocouples attached to Boumatic flow meters. Maximum air temperature and temperature-humidity index averaged 30.8 degrees C and 75.6 for July. Breed did not affect milk temperature, but within-breed milk temperature increased with production. In a second study, benefits of spray cooling were evaluated with 24 Holsteins in midlactation assigned randomly to two groups of 12 and maintained under loose-housing conditions. Spray nozzles were installed in the walkways and under the manger shade for the spray treatment group. Maximum temperature and temperature-humidity index during the spray study were 27 degrees C and 73.9. Rectal temperature taken following milking averaged less for treatment than control (38.8 versus 39.1 degrees C). Milk temperature was similar (37.8 versus 38.1 degrees C). Daily milk yield was .70 kg higher than controls. Milk temperature may provide reliable indication of climate stress similar to rectal temperature, and spray cooling improves cow comfort and lessens summer decline of milk production.     

Paraneoplastic syndromes in patients with ovarian neoplasia

The prevalence of several paraneoplastic syndromes associated with ovarian cancer was determined from a clinicopathological study of 908 patients with primary ovarian malignancy in the North East Thames Region. The diversity and rarity of these manifestations are great and the explanation for them is difficult. Circumstantial evidence suggests that in some cases an autoimmune phenomenon is the most plausible cause.     

Global self-ratings of health and mortality: hazard in the North Carolina Piedmont

We analyzed the first 5 years of surveillance data from the Established Population for the Epidemiologic Studies of the Elderly (EPESE) in the Piedmont of North Carolina (n = 4162) to estimate the effect of a global self-rating of health on survival. Covariates used in Cox proportional hazard models included sociodemographic factors, chronic medical conditions, activities of daily living, use of health services, health risk behaviors, cognitive function, affective mood, and negative life events. Adjusted risk of mortality associated with poor (compared to excellent) self-ratings of health was significantly elevated among urban men only. Confounders of the association between survival and overall health assessment varied widely by subgroup. Pooled estimates from heterogeneous populations may mask significant subgroup differences both in the pattern of variables that mediate crude risk and also in the magnitude of residual risk of global self-ratings of health.     

The effects of growth factors on Tenon''s capsule fibroblasts in serum-free culture

Recent studies from our laboratory have shown that in the mouse and rat nephron Ca2+ and Mg2+ are not reabsorbed in the medullary part of the thick ascending limb (mTAL) of Henle's loop. The aim of the present study was to investigate whether the absence of transepithelial Ca2+ and Mg2+ transport in the mouse mTAL is due to its relative low permeability to divalent cations. For this purpose, transepithelial ion net fluxes were measured by electron probe analysis in isolated perfused mouse mTAL segments, when the transepithelial potential difference (PDte.) was varied by chemical voltage clamp, during active NaCl transport inhibition by luminal furosemide. The results show that transepithelial Ca2+ and Mg2+ net fluxes in the mTAL are not driven by the transepithelial PDte. At zero voltage, a small but significant net secretion of Ca2+ into the tubular lumen was observed. With a high lumen-positive PDte generated by creating a transepithelial bath-to-lumen NaCl concentration gradient, no Ca2+ and Mg2+ reabsorption was noted; instead significant and sustained Ca2+ and Mg2+ net secretion occurred. When a lumen-positive PDte was generated in the absence of apical furosemide, but in the presence of a transepithelial bath-to-lumen NaCl concentration gradient, a huge Ca2+ net secretion and a lesser Mg2+ net secretion, not modified by ADH, were observed. Replacement of Na+ by K+ in the lumen perfusate induced, in the absence of PDte changes, important but reversible net secretions of Ca2+ and Mg2+. In conclusion, our results indicate that the passive permeability of the mouse mTAL to divalent cations is very low and not influenced by ADH. This nephron segment can secrete Ca2+ and Mg2+ into the luminal fluid under conditions which elicit large lumen-positive transepithelial potential differences. Given the impermeability of this epithelium to Ca2+ and Mg2+, the secretory processes would appear to be of cellular origin.     

Constructions of particular random processes

This paper reviews how to construct sets of random numbers with particular amplitude distributions and correlations among values. These constructions support both high-fidelity Monte Carlo simulation and analytic design studies. A variety of constructions is presented to free engineering models from “white or normal” limitations embodied in many current simulations. The methods support constructions of conventional stationary and normally distributed processes, nonstationary, nonnormal signal and interference waveforms, nonhomogeneous random scenes, nonhomogeneous volumetric clutter realizations, and snapshots of randomly evolving, nonhomogeneous scenes. Each case will have specified amplitude statistics, e.g., normal, log-normal, uniform, Weibull, or discrete amplitude statistics; and selected correlation, e.g., white, pink, or patchy statistics, clouds. or speckles. Sets of random numbers with correlation, nonstationarities, various tails for the amplitude distributions, and multimodal distributions can be constructed. The paper emphasizes aspects of probability theory necessary to engineering modeling