Completeness of reporting of diagnosed HIV-infected hospital inpatients

To assess the completeness of human immunodeficiency virus (HIV) reporting among hospital inpatients whose records listed diagnostic codes for HIV infection but who did not meet the 1987 AIDS case definition, we conducted a statewide hospital study of admissions between January 1, 1986 and December 31, 1990. Of the 396 HIV-infected hospital inpatients identified, 313 (79%) had been reported to the State HIV Registry. HIV reporting was less complete for patients who were older and/or were blood product recipients. Of the 313 reported patients, 189 (60%) had been reported prior to their first hospital admission. Temporal improvements were noted in the completeness of HIV reporting among the hospital patients (1986: 65%; 1987: 81%; 1988: 64%; 1989: 82%; 1990: 86%; Chi square for linear trend 9.6, p < 0.01) and prior to their first hospital admission (1986: 31%; 1987: 34%; 1988: 49%; 1989: 64%; 1990: 72%; Chi square for linear trend 26.6; p < 0.01). Women were more likely than men to be reported prior rather than during or after their first hospital admission (71% vs. 55%; p < 0.01). Of the 155 patients with CD4+ T-lymphocyte test results, 41 had CD4+ counts < 200 mm3 and met the 1993 but not the 1987 AIDS case definition. In South Carolina most (79%) diagnosed, hospitalized, HIV-infected patients had been reported to the State HIV REgistry, with improvements in reporting occurring over time. Findings suggest that the 1993 AIDS case definition will improve our ability to monitor severe morbidity related to HIV.     

Fraud storm surges toward HMOs

The veterinary surgeon G. C. HAUBNER (1806-1882) was teacher for veterinary science at the Royal prussian academia for agriculture in Eldena near Greifswald (1836-1852) and at the royal school of veterinary science in Dresden (1853-1879). He stimulated animal nutrition in different ways. First of all he disclosed the theoretical gaps in the field of animal nutrition during the first half of the 19th century, furthermore he transferred the knowledge in agriculture chemistry and animal physiology to feeding praxis and altogether he favoured the transition from the empirical to the scientific based animal nutrition, last not least by starting exactly planned and practiced feeding experiments (s. Table 2). Most remarkable are his very early work on digestion physiology in ruminants (1837), his proof (1854), that fiber is digestible in ruminants or horses as well as his investigations on nutrition related diseases in cattle (smelting-house-smoke- and deficiency-diseases).     

Lithium-induced follicular hyperkeratosis

Scanning with Tc-99m labeled RBC was performed in two patients with recurrent postoperative gastrointestinal bleeding after partial colonic resection. Imaging correctly identified the source of bleeding at the anastomotic site in the large bowel, effectively contributing in the patient's treatment planning. Radionuclide scintigraphy provides a simple, noninvasive modality to diagnose and manage difficult clinical situations such as postoperative bleeding.     

An atomic model of the outer layer of the bluetongue virus core derived from X-ray crystallography and electron cryomicroscopy

BACKGROUND: Bluetongue virus (BTV), which belongs to the Reoviridae family and orbivirus genus, is a non-enveloped, icosahedral, double-stranded RNA virus. Several protein layers enclose its genome; upon cell entry the outer layer is stripped away leaving a core, the surface of which is composed of VP7. The structure of the trimeric VP7 molecule has previously been determined using X-ray crystallography. The articulated VP7 subunit consists of two domains, one which is largely alpha-helical and the other, smaller domain, is a beta barrel with jelly-roll topology. The relative orientations of these two domains vary in different crystal forms. The structure of VP7 and the organizations of 780 subunits of this molecule in the core of virus is central to the assembly and function of BTV. RESULTS: A 23 A resolution map of the core, determined using electron cryomicroscopy (cryoEM) data, reveals that the 260 trimers of VP7 are organized on a rather precise T = 13 laevo icosahedral lattice, in accordance with the theory of quasi-equivalence. The VP7 layer occupies a shell that is between 260 A and 345 A from the centre of the core. Below this radius (230-260 A) lies the T = 1 layer of 120 molecules of VP3. By fitting the X-ray structure of an individual VP7 trimer onto the cryoEM BTV core structure, we have generated an atomic model of the VP7 layer of BTV. This demonstrates that one of the molecular structures seen in crystals of the isolated VP7 corresponds to the in vivo conformation of the molecule in the core. CONCLUSIONS: The beta-barrel domains of VP7 are external to the core and interact with protein in the outer layer of the mature virion. The lower, alpha-helical domains of VP7 interact with VP3 molecules which form the inner layer of the BTV core. Adjacent VP7 trimer-trimer interactions in the T = 13 layer are mediated principally through well-defined regions in the broader lower domains, to form a structure that conforms well with that expected from the theory of quasi-equivalence with no significant conformational changes within the individual trimers. The VP3 layer determines the particle size and forms a rather smooth surface upon which the two-dimensional lattice of VP7 trimers is laid down.     

认知定位系统的自适应精度研究

为了能够实现定位精度的自适应,本文分析了认知无线电定位系统(cognitive positioning systems,CPS)的原理。该系统利用频谱及环境感知等模块中的传感器单元来获取所需的定位参数,并将其与到达时间(time of arrival,TOA)定位估计算法相结合,以克拉美罗下界(Cramer-Rao lower bound,CRLB)为准则分析最大似然(maximum likelihood,ML)定位精度自适应算法。本文还对单径和多径环境条件下定位精度自适应性能进行了比较。仿真结果表明,该算法能够实现定位精度的自适应,并能通过改善系统可用的频带带宽、分散频谱的数目、信号的调制方式等因素来提高定位精度。     

基于REST架构的矿山数字移动办公平台

基于面向资源思想以及REST架构,首次提出了矿山资源抽象层的概念,将矿山中各个异构系统的功能、文档、界面、工作流等抽象为能够通过标准URI来唯一标识的抽象资源元数据,在决策或智能分析层通过对元数据的分析和处理来实现相应操作或得出相关的分析结果;提出了基于REST框架的矿山数字移动办公平台设计方案,并以神木张家峁矿业有限公司移动办公平台的建设为例,介绍了将多个异构系统快速集成在移动终端的实现方法。应用结果表明,该移动办公平台运行稳定,操作流畅,使得工作人员能够随时、随地、随手办公,大大提高了办公灵活性及效率。     

Web模式的仿真想定编辑与管理系统设计

基于虚拟战场对战场态势信息的需求,构建了Web模式的仿真想定编辑与管理系统,该系统包括仿真想定的输入,管理,编辑,标绘,输出等功能模块。在地理信息系统（Geographic Information System,GIS）和军标库等的支持下,用户可以根据具体的仿真需求,通过对仿真想定进行可视化编辑,简单灵活地实现对战场初始态势信息的输入。同时系统加强对已有的仿真想定的统一管理,建立仿真想定库,便于用户获取已有的仿真想定,大大提高其重用率,减少了不必要的重复劳动。     

NMR studies of a D2 single crystal in the ordered phase

We report the first experimental study of the NMR lineshape anisotropy in the orientationally ordered cubic phase of a D₂ single crystal. The para-D₂ concentration covered the range 0.72<X<0.82. The observed line shapes were obtained by means of Fourier transform techniques from the solid echoes recorded with a pulsed NMR spectrometer operating at 5.9 MHz. Theoretical line shapes and their second moments forp-D₂ (with angular momentumJ=1 and spinI=1) and foro-D₂ (withJ=0, I=2) were calculated as a function of the applied field direction from the theory by A. B. Harris. Good agreement was obtained for all directions, provided that, just as for solid H₂, a Gaussian function for the distribution of molecular axial alignment was assumed with an rms spreading angle of 6 deg forX=0.77. No change in the anisotropy of the second moment in the disordered phase was detected between the initial (hcp) crystal and after repeated thermal cyclings through the martensitic transition. This result implies no change in the orientation of the plane for the sliding nets during repeated passages through the transition. Furthermore, we report measurements of the longitudinal relaxation time for bothp-D₂ ando-H₂ versusT over the temperature range 0.5<T<3.5 K. The complex behavior reported previously for both H₂ and D₂ was confirmed. Measurements of the relaxation times as a function of the applied field direction in the ordered phase at 1.2 K showed no anisotropy within experimental error, and this result is discussed in the light of predictions by Hardy and Berlinsky. Finally, the polarization of theJ=0 molecules is studied as a function of the concentrationX of theJ=1 molecules and their state of orientational order over a wide range ofX andT in the ordered and disordered states. The results are compared with predictions of A. B. Harris and with previous data on polycrystalline samples.     

Thermal transport properties and size effects in very dilute superfluid mixtures of3He in4He

The effective thermal conductivity _eff has been measured for 1.6 K for mixtures with 10^–6–2. Both _eff and the derived impurity mass diffusion coefficient D_iso show an unexpected dependence on the height h of the fluid layer. A scaled representation of D_iso leads to a purely phenomenological model involving an effective length scale, proportional to X^–1 and temperature independent. The relations so obtained are consistent with the observations as well as with the observed transition curve Q_C(X) to non-linear behavior.     

Establishment of a reference library for evaluating computer ECG measurement programs

As a result of an international cooperative project entitled "Common Standards for Quantitative Electrocardiography" (CSE), an ECG reference data base has been established with the aim of standardizing computer-derived ECG measurements. The objective of the project is to reduce the wide variation in wave measurements currently obtained by ECG analysis programs. A library of 250 ECGs with selective ECG abnormalities was established and a comprehensive reviewing scheme was devised for the visual determination of the onsets and offsets of P, QRS, and T. This task was performed by a board of cardiologists on highly amplified, selected complexes from the library. A subset was examined in order to study beat-to-beat and intraobserver variability. By using a modified Delphi approach, individual outlying point estimates were eliminated in four successive rounds. In this way final referee estimates were obtained which proved to be highly reproducible and precise. A reference library has thereby been developed which allows testing of the performance of ECG measurement programs and is a useful instrument in establishing recommendations for more precise measurement rules and definitions.