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排序方式: 共有10000条查询结果,搜索用时 15 毫秒
91.
92.
DL Lacey JM Erdmann SL Teitelbaum HL Tan J Ohara A Shioi 《Canadian Metallurgical Quarterly》1995,136(6):2367-2376
Interleukin 4 (IL-4) is an immune cytokine that inhibits bone resorption in mice and suppresses osteoclastic cell formation in vitro through an undefined mechanism. In this report, we have established the cellular identity of the IL-4 target cell using a variety of bone marrow/stromal cell coculture methods. Initially, we found that the majority of IL-4's inhibition of osteoclastic cell formation was due to its effect on bone marrow cells, not stromal cells. Consequently, bone marrow macrophages were used as osteoclastic cell progenitors after they had been transiently exposed to IL-4 (48 h), before the addition of stromal cells, 1,25-dihydroxyvitamin D3, and dexamethasone. In this circumstance, IL-4 impaired subsequent osteoclastic cell formation, suggesting that the macrophage may be potentially targeted by many factors known to influence osteoclast formation. Consequently, we discovered that interferon-gamma (IFN gamma), prostaglandin E (PGE), and cell-permeant cAMP analogs also impacted osteoclastic cell formation when used to selectively treat bone marrow macrophages. IFN gamma suppressed osteoclastic cell formation, whereas PGE and cAMP analog treatment led to the formation of significantly enlarged osteoclastic cells. Importantly, PGE antagonized the inhibitory effects of both IL-4 and IFN gamma on the osteoclastic cell-forming potential of bone marrow macrophages. Collectively, these findings establish bone marrow macrophages as osteoclastic cell precursors with the degree of their commitment to the osteoclast pathway sensitive to the effects of soluble mediators, including IL-4, IFN gamma, and PGE. 相似文献
93.
94.
RG Wilde JT Billheimer SJ Germain EA Hausner PC Meunier DA Munzer JK Stoltenborg PJ Gillies DL Burcham SM Huang JD Klaczkiewicz SS Ko RR Wexler 《Canadian Metallurgical Quarterly》1996,4(9):1493-1513
Acyl-CoA:cholesterol acyltransferase (ACAT) is the enzyme largely responsible for intracellular cholesterol esterification. A systemic inhibitor of ACAT is believed to be able to slow or even reverse the atherosclerotic process. Towards that goal, a series of cyclic sulfides, derived from the hetero-Diels-Alder reaction of thioaldehydes with 1,3-dienes, and bearing carboxamide substituents, were prepared and evaluated for in vitro (in several tissues and species) and ex vivo ACAT inhibition. Minor changes in subsequent structure were found to have a significant effect in optimization of the biological activity of this series of compounds. 相似文献
95.
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97.
R Bascom J Kesavanathan TK Fitzgerald KH Cheng DL Swift 《Canadian Metallurgical Quarterly》1995,103(11):1026-1030
Nasal mucociliary clearance (NMC) is a biomarker of nasal mucosal function. Tobacco smokers have been shown to have abnormal NMC, but the acute effect of environmental tobacco smoke (ETS) on nonsmokers is unknown. This study evaluated acute tobacco smoke-induced alterations in NMC in 12 healthy adults. Subjects were studied on 2 days, separated by at least 1 week. Subjects underwent a 60-min controlled exposure at rest to air or sidestream tobacco smoke (SS) (15 ppm CO) in a controlled environmental chamber. One hour after the exposure, 99mTc-sulfur colloid was aerosolized throughout the nasal passage and counts were measured with a scintillation detector. Six out of 12 subjects showed more rapid clearance after smoke exposure than after air exposure, and 3/12 had rapid clearance on both days. However, substantial decreases in clearance occurred in 3/12 subjects, all of whom had a history of ETS rhinitis. In two subjects, more than 90% of the tracer remained 1 hr after tracer administration (2 hr after smoke exposure). Understanding the basis for biologic variability in the acute effect of tobacco smoke on NMC may advance our understanding of pathogenesis of chronic effects of ETS. 相似文献
98.
一种高性能的适用于AVS的二维整数逆变换实现结构 总被引:1,自引:0,他引:1
针对AVS视频标准中的整数逆变换,本文提出了一种高性能的硬件实现方案.本方案采用两个一维逆变换核和4个16(16的双口SRAM.通过合理控制SRAM的读写方式,避免了数据的预处理与后处理,流水线的深度也得到减少.在列变换时,改变数据运算次序,从而保证了4个双口SRAM不影响运算速度.处理8(8的数据块,本结构仅需要37个时钟,与传统的实现方案相比,在同等运算速度下,面积节约28%.实验表明该结构适用于采用AVS标准的HDTV编解码器. 相似文献
99.
文章对非标准工况下的空分设备增产氩措施进行了研究。以宝钢6#60000m3/h空分设备为例,通过设计型算法和校核型算法,建立了空分设备精馏的数学模型,通过改变数学模型的参数,分析了在非标准工况下精馏塔内的组分浓度分布,并提出了优化后的操作方案和操作参数,实施后提高了空分设备的氩提取率,取得了显著的经济效益。 相似文献
100.
高压注水管柱受力分析 总被引:3,自引:3,他引:0
进行高压注水管柱受力分析的目的就是根据注水条件研究注水管柱在不同过程中的各类效应,以及这些效应对管柱产生的受力和变形规律,从而明确注水管柱的工作状态,保障注水管柱有效合理地工作。较详细地分析了高压注水管柱在锚定、坐封以及注水3个过程中的受力状态和变形情况,并分析了高压注水管柱在不同过程中受到的各种效应的影响,推导出注水管柱在不同过程中的应力及变形的计算公式,并给出了算例。 相似文献