全文获取类型
收费全文 | 4802篇 |
免费 | 21篇 |
国内免费 | 1篇 |
专业分类
电工技术 | 20篇 |
综合类 | 3篇 |
化学工业 | 124篇 |
金属工艺 | 21篇 |
机械仪表 | 22篇 |
建筑科学 | 28篇 |
矿业工程 | 3篇 |
能源动力 | 18篇 |
轻工业 | 78篇 |
水利工程 | 5篇 |
石油天然气 | 5篇 |
无线电 | 148篇 |
一般工业技术 | 207篇 |
冶金工业 | 4036篇 |
原子能技术 | 15篇 |
自动化技术 | 91篇 |
出版年
2021年 | 11篇 |
2019年 | 6篇 |
2018年 | 15篇 |
2017年 | 12篇 |
2016年 | 7篇 |
2015年 | 9篇 |
2014年 | 11篇 |
2013年 | 42篇 |
2012年 | 24篇 |
2011年 | 40篇 |
2010年 | 24篇 |
2009年 | 21篇 |
2008年 | 32篇 |
2007年 | 48篇 |
2006年 | 29篇 |
2005年 | 23篇 |
2004年 | 25篇 |
2003年 | 29篇 |
2002年 | 25篇 |
2001年 | 27篇 |
2000年 | 12篇 |
1999年 | 155篇 |
1998年 | 1222篇 |
1997年 | 705篇 |
1996年 | 483篇 |
1995年 | 253篇 |
1994年 | 203篇 |
1993年 | 234篇 |
1992年 | 46篇 |
1991年 | 85篇 |
1990年 | 81篇 |
1989年 | 71篇 |
1988年 | 71篇 |
1987年 | 71篇 |
1986年 | 44篇 |
1985年 | 60篇 |
1984年 | 7篇 |
1983年 | 22篇 |
1982年 | 30篇 |
1981年 | 34篇 |
1980年 | 43篇 |
1979年 | 21篇 |
1978年 | 20篇 |
1977年 | 97篇 |
1976年 | 222篇 |
1975年 | 11篇 |
1974年 | 9篇 |
1973年 | 6篇 |
1970年 | 6篇 |
1969年 | 5篇 |
排序方式: 共有4824条查询结果,搜索用时 15 毫秒
41.
42.
S Hunt Gerardo DM Citron MC Claros EJ Goldstein 《Canadian Metallurgical Quarterly》1996,40(10):2413-2415
When the Etest was compared to broth microdilution for susceptibility testing of Streptococcus pneumoniae, levofloxacin, erythromycin, and penicillin results correlated for both methods; azithromycin and clarithromycin showed discrepancies of > or = 2 dilutions for 95.8% and 31.5% of the isolates, respectively. Levofloxacin was active against 141 of 142 isolates (< or = 2.0 micrograms/ml), making it a potentially useful new fluoroquinolone. 相似文献
43.
The redistribution of spin-labeled phospholipid analogs across the plasma membrane of HepG2 cells, either in suspension or grown as monolayers, was investigated. After incorporation into the outer membrane leaflet spin-labeled aminophospholipids phosphatidylserine (PS) and phosphatidylethanolamine (PE) moved rapidly to the inner monolayer, whereas the analog of phosphatidylcholine (PC) disappeared more slowly from the outer leaflet. The fast, inward movement of the aminophospholipids was abolished after adenosine triphosphate (ATP)-depletion of cells, suggesting the presence of an aminophospholipid translocase in the plasma membrane of these cells. Compared with human red blood cells, the activity of the aminophospholipid translocase is two orders of magnitude higher in HepG2 cells. From these data, a transverse phospholipid asymmetry can be inferred with the aminophospholipids mainly concentrated on the inner monolayer and the choline-containing phospholipids on the outer leaflet. The relevance of the enrichment of PC in the outer membrane leaflet for the formation and composition of the bile is discussed. 相似文献
44.
JJ Bull MR Badgett HA Wichman JP Huelsenbeck DM Hillis A Gulati C Ho IJ Molineux 《Canadian Metallurgical Quarterly》1997,147(4):1497-1507
Replicate lineages of the bacteriophage phiX 174 adapted to growth at high temperature on either of two hosts exhibited high rates of identical, independent substitutions. Typically, a dozen or more substitutions accumulated in the 5.4-kilobase genome during propagation. Across the entire data set of nine lineages, 119 independent substitutions occurred at 68 nucleotide sites. Over half of these substitutions, accounting for one third of the sites, were identical with substitutions in other lineages. Some convergent substitutions were specific to the host used for phage propagation, but others occurred across both hosts. Continued adaptation of an evolved phage at high temperature, but on the other host, led to additional changes that included reversions of previous substitutions. Phylogenetic reconstruction using the complete genome sequence not only failed to recover the correct evolutionary history because of these convergent changes, but the true history was rejected as being a significantly inferior fit to the data. Replicate lineages subjected to similar environmental challenges showed similar rates of substitution and similar rates of fitness improvement across corresponding times of adaptation. Substitution rates and fitness improvements were higher during the initial period of adaptation than during a later period, except when the host was changed. 相似文献
45.
46.
Robotic synthesis is making possible the synthesis of large, systematically designed sets of compounds. We analyze a 512-compound set that is a 2(9) full factorial experimental design using a recursive partitioning algorithm, FIRM, and a high-dimension visualization tool, TempleMVV. These techniques are used to quickly and easily identify the main trends in the data set and also identify unusual observations. We show that analytical and visualization methods can be used synergistically to analyze a large, complex, high-dimensional data set. We also show that a fractional factorial design of 128 compounds would give essentially the same information. 相似文献
47.
48.
There is now strong evidence that the chorioretinal degeneration associated with ornithine-delta-aminotransferase (OAT) deficiency is a consequence of hyperornithinemia. Therefore development of a metabolic system for clearing ornithine from the circulation is being pursued as a potential treatment. The skin is considered an attractive location for such a metabolic system because autologous cells can be safely and easily utilized. This study was undertaken to determine the ornithine metabolizing capacity of epidermal keratinocytes expressing normal and superphysiologic amounts of OAT. The data show that overexpression of OAT in keratinocytes cultured from a gyrate atrophy patient restores ornithine metabolism and results in a rate of ornithine disappearance from the medium that is significantly higher than the rate of disappearance from the medium bathing normal keratinocytes. In addition, OAT activity determined in soluble protein prepared from sonicates suggests that the capacity to maintain plasma ornithine within the normal range is contained within an accomplishable graft of keratinocytes overexpressing OAT. However, the actual rate of ornithine disappearance from the media was significantly less than predicted from enzyme activity assays. Following ornithine metabolite production by intact cells suggests that ornithine metabolism is limited primarily by clearance of downstream metabolites, as opposed to substrate delivery. 相似文献
49.
50.