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91.
DJ Kereiakes AM Lincoff DP Miller JE Tcheng CF Cabot KM Anderson HF Weisman RM Califf EJ Topol 《Canadian Metallurgical Quarterly》1998,97(9):857-864
BACKGROUND: Recent studies indicate that eradication of Helicobacter pylori might prevent peptic ulcer formation in patients treated with non-steroidal anti-inflammatory drugs (NSAIDs). On the other hand, gastric adaptation after repeated exposures to aspirin (ASA) is well documented but the influence of H. pylori on this process remains to be elucidated. AIM: To compare gastric damage and adaptation following repeated exposures to ASA in a group of patients with H. pylori infection, before and after eradication of the bacterium, and in H. pylori-negative controls. METHODS: Eight healthy volunteers without H. pylori infection and eight patients with duodenal ulcer (DU) history and H. pylori infection before and after H. pylori eradication were given ASA 2 g/day for a period of 14 days. Mucosal damage was evaluated by endoscopy and histology of biopsy samples. Gastric microbleeding, DNA synthesis in the gastric mucosa and mucosal expression, as well as luminal content of transforming growth factor-alpha (TGFalpha) were determined on days 0, 3, 7 and 14 of the ASA course. RESULTS: In all patients aspirin-induced gastric damage reached a maximum on day 3. In H. pylori-positive patients, this damage was maintained at a similar level up to day 14, whereas in H. pylori-negative controls and H. pylori-eradicated patients this damage significantly lessened on day 14 and was accompanied by elevated DNA synthesis as well as increased mucosal expression and luminal release of TGFalpha. 相似文献
92.
N Raskin A Jakubowski ID Sizing DL Olson SL Kalled CA Hession CD Benjamin DP Baker LC Burkly 《Canadian Metallurgical Quarterly》1998,161(7):3474-3483
The IL receptor common gamma (gamma c) chain is required for the formation of high affinity cytokine receptor complexes for IL-2, IL-4, IL-7, IL-9, and IL-15, and for signals regulating cell survival, growth, and differentiation. Our current understanding of how gamma c chain associates with multiple ligands and receptor subunits is drawn largely from its structural homology to the human growth hormone (hGH) receptor and known structure of the hGH/hGH receptor complex. These receptors share distinct features in their extracellular portions and are believed to function by a mechanism of ligand-induced association of receptor subunits. Here, we report the first directed mutational analysis of the human gamma c chain by alanine scanning conducted across seven regions likely to contain residues required for intermolecular contact. Functionally distinct, neutralizing anti-gamma c mAbs were employed to define critical residues. One particular mAb, CP.B8, unique in its ability to inhibit IL-2-, IL-4-, IL-7-, and IL-15-induced proliferation and high affinity cytokine binding of normal T cells as an intact mAb and as a Fab fragment, localized critical residues to four noncontinuous stretches, namely residues in loops AB and EF of domain 1, in the interdomain segment, and in loop FG of domain 2. Notably, these residues form a contiguous patch on the gamma c chain surface in a three-dimensional structural model. These results provide functional evidence for the location of contact points on gamma c chain required for its association with multiple ligands. 相似文献
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RM Anderson PA Barr GJ Edwards MM Funnell JT Fitzgerald K Wisdom 《Canadian Metallurgical Quarterly》1996,22(1):28-33
BACKGROUND: Human serum represents an important barrier to the entry of most mucosal organisms into tissues and to the systemic circulation. If at all present, Helicobacter pylori within gastric tissue is rare, and bacteremia for this organism has been described only once. METHODS: To assess the susceptibility of H. pylori to the bactericidal activity present in normal human serum (NHS), we examined 13 H. pylori isolates. To assess the contributions of the classical and alternative complement pathways to killing, we added either C2-deficient or factor B-deficient serum, respectively, to heat-inactivated NHS. Also we assessed the ability of the strains to bind 125I-C3. RESULTS: After incubation for 60 minutes at 37 degrees C, all 13 H. pylori strains were killed by NHS; heating to 56 degrees C for 30 minutes ablated killing, indicating complement dependence for this phenomenon. In the absence of an antibody source, there was no killing when either an alternative or classical complement pathway source was used. Adding B-deficient serum to heat-inactivated normal human serum did not restore killing, but adding C2-deficient serum permitted partial killing. All of the 13 strains bound 125I-C3. Although the kinetics varied from strain to strain, C3 bound was significantly correlated (r = 0.61, p = 0.03) with serum susceptibility. CONCLUSIONS: H. pylori are susceptible to complement, alternative pathway activation appears critical, and C3 binding is a major locus of variability. 相似文献
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R C Barr 《IEEE transactions on bio-medical engineering》1984,31(8):546-550
In cardiac muscle times of excitation, the site of origin of excitation and propagation velocity usually are determined from the intrinsic deflections of a collection of extracellular waveforms. Separate waveforms are measured from each site for which an excitation time is to be found. Most of the information in each measured waveshape is discarded, even though waveshape features have been shown to be closely related to propagation characteristics. The objective of this paper is to examine the possibility of more fully utilizing all of the information in the extracellular waveform. Would a small number of measured waveforms, used more completely, be sufficient to find the site of origin, propagation velocity, and excitation times? A computer simulation of intra-and extracellular excitation along a one-dimensional cylindrical cardiac strand provided the framework for the evaluation. The dimensions and the-conductivity of the strand and the action potential shape were assumed known. Extracellular waveforms were simulated at 2 of 51 points on the strand and thereafter taken to be "measurements.?" The objectives were to calculate, from the "measured" waveforms, the site of origin of excitation (possibly anywhere along the strand), the speed of propagation, and the times of excitaion at all 51 points. Propagation speed was assumed constant, but of unknown magnitude, in both directions away from the site of excitation. Notable results of the study include correctly differentiating among different sequences of excitation having identical time differences between the intrinsic deflections of the two known extracellular waveforms. 相似文献
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