Proteome analysis of substantia nigra and striatal tissue in the mouse MPTP model of Parkinson's disease

The dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) replicates many of the pathological hallmarks of Parkinson's disease (PD) in mice via selective destruction of dopamine neurons of the substantia nigra and striatum. Although MPTP has been widely used to study downstream effects following the degeneration of dopaminergic neurons, the underlying mechanisms of MPTP action remain poorly understood. To determine the underlying mechanisms of MPTP action at the protein level, a 2-DE-based proteomics approach was used to evaluate the changes in protein expression in substantia nigra and striatal tissue in C57BL/6 mice after MPTP administration. We identified nine proteins that were markedly altered and are likely to be involved in mitochondrial function, heat shock protein activity, and which contribute enzyme activities for energy metabolism and protein degradation.     

Distinguishing the medicinal herb Oldenlandia diffusa from similar species of the same genus using fluorescence microscopy

The light microscope is routinely used for microscopic identification of Chinese Materia Medica (CMM). However, the fluorescence microscope has not been used for this purpose until now. The CMM, Baihuasheshecao, mostly used as a component of herb tea, is a well known folk-medicine in China. According to the Chinese Pharmacopoeia, its source is the species Oldenlandia diffusa (Willd.) Roxb. Two other species of the same genus, namely O. corymbosa (L.) Lam and O. tenelliflora Bl., had been found in use as Baihuasheshecao. To find a quick and easy method to distinguish O. diffusa from these similar species of the same genus, the fluorescence microscope was used to investigate the fluorescence emission characteristics of the three tissues, which were compared with light microscopy images of the same material. The results showed that some tissues of the three herbs emit autofluorescence. Specially, the wall of endoderm cells of O. diffusa and O. tenelliflora emit autofluorescence, while similar tissue of O. corymbosa does not. Hence, fluorescence microscopy can be helpful in the identification of CMM.     

PROFIBUS和AS-I总线在汽车生产线中的应用

本文简单介绍了PROFIBUS和AS-I现场总线的原理并详细说明了它们在汽车生线的应用.     

Windows9x中串并行并存通讯系统设计与实现

详细介绍了运用面向对象程序设计语言VB5．0,开发在同一智能系统中同时采用RS232串口和GPIB并口的综合性实时数据采集处理系统的实现,解决了MSComm控件在VB5．0及5．0以上版本中应用于仪器命令字的ASCⅡ码传送时的特殊问题。     

Influence-based model decomposition for reasoning about spatially distributed physical systems

Many important science and engineering applications, such as regulating the temperature distribution over a semiconductor wafer and controlling the noise from a photocopy machine, require interpreting distributed data and designing decentralized controllers for spatially distributed systems. Developing effective computational techniques for representing and reasoning about these systems, which are usually modeled with partial differential equations (PDEs), is one of the major challenge problems for qualitative and spatial reasoning research.

This paper introduces a novel approach to decentralized control design, influence-based model decomposition, and applies it in the context of thermal regulation. Influence-based model decomposition uses a decentralized model, called an influence graph, as a key data abstraction representing influences of controls on distributed physical fields. It serves as the basis for novel algorithms for control placement and parameter design for distributed systems with large numbers of coupled variables. These algorithms exploit physical knowledge of locality, linear superposability, and continuity, encapsulated in influence graphs representing dependencies of field nodes on control nodes. The control placement design algorithms utilize influence graphs to decompose a problem domain so as to decouple the resulting regions. The decentralized control parameter optimization algorithms utilize influence graphs to efficiently evaluate thermal fields and to explicitly trade off computation, communication, and control quality. By leveraging the physical knowledge encapsulated in influence graphs, these control design algorithms are more efficient than standard techniques, and produce designs explainable in terms of problem structures.     

智能软件:由面向对象到面向Agent

文章对照了面向Agent与面向对象的概念、基本思想和运行机制,分析了面向对象的不足和面向Agent在封装、通信、运行等方面的优势,说明了由面向对象到面向Agent将是分布和智能化软件的必然选择。     

求解货郎担问题(TSP)的佳点集遗传算法

文章针对求解货郎担问题（ＴＳＰ）,给出了一种佳点集遗传算法。通过对ＣＨＮ１４４实例的仿真求解,取得了令人满意的结果,可以看出该算法不仅提高了求解的效率和精度,还有效地避免了“早熟”现象。     

"农业经营簿记系统"的设计和实现

Internet技术的发展为传统MIS系统的设计和实现注入了新的内容。本文以“农业经营簿记系统”为实例,详细介绍了系统的设计、实现及其功能模块,并对一些典型问题进行了探讨。     

Pseudoelastic behavior in Y1−xPrxBa2Cu3Oy compounds

Tensile tests show that ferroelastic loops always occur at 100–150 K, 200–250 K and room temperature in the Y_1–xPr_xBa₂Cu₃O_y samples withx=0 and 0.1 for whichT _c is 92 K and 82.5 K respectively, and the shape memory effect is always observed in the compact sample near 130 K, just similar to that of thermal elastic martensitic alloys. The loss fraction (W/W) which is proportional to the area of ferroelastic loop as a function of temperature shows that there always exist static hysteresis (W/W) peaks at 130 K and 110 K which are attributed to the phaselike transition (PLT) characterized by the jump of lattice parameters. No ferroelastic loops and shape memory effect are observed in the range of 100 K to 150 K for the lowerT _c samples withx=0.3, 0.4 and 0.6.     

Intranet网在企业中的应用

本文提出了一个在企业内部实现Intranet网的方案,该系统是为一个具有多个、分散在不同地域的子公司的集团性企业而设计。整个企业的网络是面向多地区服务的广域企业信息网,它能有效地集中管理企业内部信息和各种资源。总公司及其分公司分别构建本地局域网,再通过接入Internet网连成广域网。该网的拓扑结构是建立在可靠、合理、安全和经济的原则上而设计的,网络的软件系统选定包括网络和客户端操作系统、网络协议、数据库管理系统、办公自动化应用系统及管理信息系统等,均考虑到使其具有良好的开放性和可扩充性。网络中亦考虑到了系统的安全性。