Implementing assistive technology on wearable computers

What might seem perfectly intuitive to a young rehabilitation engineer designing assistive devices might not be intuitive at all to a disabled or elderly person experiencing a serious loss of function for the first time. When designers understand the complex nature of disabilities, they are more likely to meet the disabled users' needs. Using the results of his work in designing assistive technology, the author describes impaired people's needs and offers design strategies to accommodate them. He also presents his research to develop a wearable computer-based orientation and wayfinding aid for the severely visually impaired.     

An inter-regional comparison: fatal crashes in the southeastern and non-southeastern United States: preliminary findings

The southeastern United States, particularly those states representing the National Highway Traffic Safety Administration's and Federal Highway Administration's Region IV, have consistently had among the highest number of fatal crashes and fatal crash rates compared to the other five regions in the US. These states--Alabama, Florida, Georgia, Kentucky, Mississippi, North Carolina, South Carolina, and Tennessee, are suspected of sharing traits in common that lead to their systematically poor crash record. Inter-regional and intra-regional comparisons, such as the comparison between southeastern and non-southeastern states, raises interesting and challenging research questions that are applicable to similar comparisons. First, is there a sound practical and theoretical justification supporting an inter-regional comparison framework? Second, is there a way to construct a meaningful statistical hypothesis and test to determine whether one region, which is comprised of numerous entities, suffers from a characteristically better or worse crash record? This paper addresses each of these questions. After providing a brief summary of the Southeast's safety record, we discuss the issues pro and con surrounding inter-regional comparisons, illustrating the statistical strategy for such an analysis approach. Then, a simple generalizable statistical procedure is used for testing the hypothesis that southeastern states have a poorer crash record than non-southeastern states. Finally, we explore possible relationships between safety belt use, roadway functional class, vehicle miles of travel, and driver age on fatal crash occurrence. The data used in the analyses are from the Fatal Analysis Reporting System (FARS), primarily data compiled for 1995. The analysis suggests that regional differences in fatal crashes may indeed exist, that these differences are related in part to seat-belt use, VMT by functional classification, and speed limit differences, and that more detailed studies are needed to quantify the effect of these and other factors. The approach developed here lends insight as to where future in-depth studies may reveal causal factors of fatal crashes, and illustrates the relative safety performance records of US regions.     

Biometrics: a tool for information security

Establishing identity is becoming critical in our vastly interconnected society. Questions such as "Is she really who she claims to be?," "Is this person authorized to use this facility?," or "Is he in the watchlist posted by the government?" are routinely being posed in a variety of scenarios ranging from issuing a driver's license to gaining entry into a country. The need for reliable user authentication techniques has increased in the wake of heightened concerns about security and rapid advancements in networking, communication, and mobility. Biometrics, described as the science of recognizing an individual based on his or her physical or behavioral traits, is beginning to gain acceptance as a legitimate method for determining an individual's identity. Biometric systems have now been deployed in various commercial, civilian, and forensic applications as a means of establishing identity. In this paper, we provide an overview of biometrics and discuss some of the salient research issues that need to be addressed for making biometric technology an effective tool for providing information security. The primary contribution of this overview includes: 1) examining applications where biometric scan solve issues pertaining to information security; 2) enumerating the fundamental challenges encountered by biometric systems in real-world applications; and 3) discussing solutions to address the problems of scalability and security in large-scale authentication systems.     

D-Tyrosine as a chiral precusor to potent inhibitors of human nonpancreatic secretory phospholipase A2 (IIa) with antiinflammatory activity

Few reported inhibitors of secretory phospholipase A(2) enzymes truly inhibit the IIa human isoform (hnpsPLA(2)-IIa) noncovalently at submicromolar concentrations. Herein, the simple chiral precursor D-tyrosine was derivatised to give a series of potent new inhibitors of hnpsPLA(2)-IIa. A 2.2-A crystal structure shows an inhibitor bound in the active site of the enzyme, chelated to a Ca(2+) ion through carboxylate and amide oxygen atoms, H-bonded through an amide NH group to His48, with multiple hydrophobic contacts and a T-shaped aromatic-group-His6 interaction. Antiinflammatory activity is also demonstrated for two compounds administered orally to rats.     

The response of lif thermoluminescence dosemeters to photon beams in the energy range from 30 kV x rays to 60Co gamma rays

The energy response of standard (TLD-100) and high-sensitivity (TLD-100H) LiF thermoluminescence dosemeters (TLDs) has been studied for photon beams with mean energies from about 25 keV to 1100 keV. Canadian primary standards for air kerma were used to establish the air kerma rates for each of the photon beams. TLDs were mounted in a PMMA holder and the air kerma response was measured as a function of energy. The EGSnrc Monte Carlo code was used to model the TLD holder and calculate the absorbed dose to the TLD chip per unit air kerma for each beam. The measured and calculated results were combined to obtain the intrinsic dose response of the TLD chip. Broadly, our results are consistent with existing data, which show a marked difference in the energy dependence of the two materials. However, the precision of our measurements (standard uncertainty of about 0.6%) has permitted the identification of features that have not been noted before. In particular, the energy dependence of the two materials is quite different in the important energy region delimited by 137Cs and 60Co gamma rays.     

High-resolution capillary tube NMR. A miniaturized 5-microL high-sensitivity TXI probe for mass-limited samples,off-line LC NMR,and HT NMR

A new triple-resonance (TXI) (1H, 13C, 15N) high-resolution nuclear magnetic resonance (NMR) capillary probe with 2.5-microL NMR-active sample volume (V(obs)) was built and tested for applications with mass- and volume-limited samples and for coupling of microbore liquid chromatography to NMR. This is the first microliter probe with optimized coil geometry for use with individual capillary tubes with an outer diameter of 1 mm. The 90 degree pulse lengths of the 1-mm microliter probe were below 2 micros for proton, below 8 micros for carbon, and below 20 micros for nitrogen, and a spectral line width at signal half-height below 1 Hz was obtained. Compared to a conventional 5-mm probe, the new 600-MHz 1-mm TXI microliter probe with z-gradient shows an increase in mass sensitivity by a factor of 5, corresponding to a 25-fold reduction in measuring time. The consumption of costly deuterated solvent is reduced by at least 2 orders of magnitude. The 1-mm TXI microliter probe with z-gradient allows the measurement of one-dimensional 1H NMR and two-dimensional heteronuclear NMR spectra with a few nanomoles (micrograms) of compound with high sensitivity, speed, and quality. This is a breakthrough for discrete sample NMR spectroscopy with paramount importance for structure elucidation in natural compound chemistry and metabolic research. It offers also advantages for linking chromatographic methods to NMR in a nindustrial environment. Capillary tube NMR may find new applications in areas where high sample throughput is essential, e.g., in the quality control of large sample arrays from parallel chemistry, screening, and compound depositories. It has the potential to increase the sample throughput by 1 order of magnitude or more if new hardware for fast sample handling and exchange becomes available.     

Atmospheric Trace Molecule Spectroscopy (ATMOS) Experiment Version 3 data retrievals

Version 3 of the Atmospheric Trace Molecule Spectroscopy (ATMOS) experiment data set for some 30 trace and minor gas profiles is available. From the IR solar-absorption spectra measured during four Space Shuttle missions (in 1985, 1992, 1993, and 1994), profiles from more than 350 occultations were retrieved from the upper troposphere to the lower mesosphere. Previous results were unreliable for tropospheric retrievals, but with a new global-fitting algorithm profiles are reliably returned down to altitudes as low as 6.5 km (clouds permitting) and include notably improved retrievals of H2O, CO, and other species. Results for stratospheric water are more consistent across the ATMOS spectral filters and do not indicate a net consumption of H2 in the upper stratosphere. A new sulfuric-acid aerosol product is described. An overview of ATMOS Version 3 processing is presented with a discussion of estimated uncertainties. Differences between these Version 3 and previously reported Version 2 ATMOS results are discussed. Retrievals are available at http://atmos.jpl.nasa.gov/atmos.     

Immobilization of DNA hydrogel plugs in microfluidic channels

Acrylamide-modified DNA probes are immobilized in polycarbonate microfluidic channels via photopolymerization in a polyacrylamide matrix. The resulting polymeric, hydrogel plugs are porous under electrophoretic conditions and hybridize with fluorescently tagged complementary DNA. The double-stranded DNA can be chemically denatured, and the chip may be reused with a new analytical sample. Conditions for photopolymerization, hybridization, and denaturation are discussed. We also demonstrate the photopolymerization of plugs containing different DNA probe sequences in one microfluidic channel, thereby enabling the selective detection of multiple DNA targets in one electrophoretic pathway.     

Model for optical forward scattering by nonspherical raindrops

We describe a numerical model for the interaction of light with large raindrops using realistic nonspherical drop shapes. We apply geometrical optics and a Monte Carlo technique to perform ray traces through the drops. We solve the problem of diffraction independently by approximating the drops with area-equivalent ellipsoids. Scattering patterns are obtained for different polarizations of the incident light. They exhibit varying degrees of asymmetry and depolarization that can be linked to the distortion and thus the size of the drops. The model is extended to give a simplified long-path integration.     

Microfluidic temperature gradient focusing

A new technique is described for the concentration and separation of ionic species in solution within microchannels or capillaries. Concentration is achieved by balancing the electrophoretic velocity of an analyte against the bulk flow of solution in the presence of a temperature gradient. With an appropriate buffer, the temperature gradient can generate a corresponding gradient in the electrophoretic velocity, so that the electrophoretic and bulk velocities sum to zero at a unique point, and the analyte will be focused at that point. The technique is demonstrated for a variety of analytes, including fluorescent dyes, amino acids, DNA, proteins, and particles, and is shown to be capable of greater than 10,000-fold concentration of a dilute analyte.