Peptidyl Virus-Like Nanovesicles as Reconfigurable “Trojan Horse” for Targeted siRNA Delivery and Synergistic Inhibition of Cancer Cells

The self-assembly of peptidyl virus-like nanovesicles (pVLNs) composed of highly ordered peptide bilayer membranes that encapsulate the small interfering RNA (siRNA) is reported. The targeting and enzyme-responsive sequences on the bilayer's surface allow the pVLNs to enter cancer cells with high efficiency and control the release of genetic drugs in response to the subcellular environment. By transforming its structure in response to the highly expressed enzyme matrix metalloproteinase 7 (MMP-7) in cancer cells, it helps the siRNA escape from the lysosomes, resulting in a final silencing efficiency of 92%. Moreover, the pVLNs can serve as reconfigurable “Trojan horse” by transforming into membranes triggered by the MMP-7 and disrupting the cytoplasmic structure, thereby achieving synergistic anticancer effects and 96% cancer cell mortality with little damage to normal cells. The pVLNs benefit from their biocompatibility, targeting, and enzyme responsiveness, making them a promising platform for gene therapy and anticancer therapy.     

基于CBS模式的档案管理数字化系统的研究

随着我国经济和社会的飞速发展.人民对信息的要求日益提高.档案管理在这种新的形势下.面临巨大的挑战.传统的档案管理已经不能适应新形势的发展,档案管理数字化系统进行研究势在必行.本文主要对档案管理的涵义、数字化系统方案设计.文档图像处理和系统软件部分等进行了相应的阐述.本文的研究对以后指导档案管理工作具有一定的理论意义和现实意义.     

Scalable multi-variate analytics of seismic and satellite-based observational data

Over the past few years, large human populations around the world have been affected by an increase in significant seismic activities. For both conducting basic scientific research and for setting critical government policies, it is crucial to be able to explore and understand seismic and geographical information obtained through all scientific instruments. In this work, we present a visual analytics system that enables explorative visualization of seismic data together with satellite-based observational data, and introduce a suite of visual analytical tools. Seismic and satellite data are integrated temporally and spatially. Users can select temporal ;and spatial ranges to zoom in on specific seismic events, as well as to inspect changes both during and after the events. Tools for designing high dimensional transfer functions have been developed to enable efficient and intuitive comprehension of the multi-modal data. Spread-sheet style comparisons are used for data drill-down as well as presentation. Comparisons between distinct seismic events are also provided for characterizing event-wise differences. Our system has been designed for scalability in terms of data size, complexity (i.e. number of modalities), and varying form factors of display environments.     

A comparative study of two techniques for improving power‐handling capability of CMOS T/R switches

This article proposes an asymmetric topology for transmit/receive (T/R) switches and more importantly presents a comparative study of both LC‐tuned and resistive body‐floating techniques for improving the power‐handling capability of the T/R switches in the same 0.18‐μm triple‐well CMOS. It is shown from simulations and measurements that the switches adopting either technique achieve comparable performances. For instance, the switch employing the LC‐tuned body‐floating technique exhibits insertion loss of 1.5 dB, isolation of 23.5 dB, and power‐handling capability of 22.5 dBm at 5.2 GHz, whereas the switch using the resistive body‐floating technique exhibits insertion loss of 1.3 dB, isolation of 24 dB, and power‐handling capability of 22.2 dBm, respectively. Therefore, one can conclude that the asymmetric topology with the resistive body‐floating technique is more suitable for designing T/R switches for wireless local area network applications as it consumes smaller silicon area. © 2010 Wiley Periodicals, Inc. Int J RF and Microwave CAE, 2010.     

Tuning of multi-loop PI controllers based on gain and phase margin specifications

In this paper, a single-iteration strategy is proposed for the design of a multi-loop PI controller to achieve the desired gain and phase margins for two-input and two-output (TITO) processes. To handle loop interactions, a TITO system is converted into two equivalent single loops with uncertainties drawn from interactions. The maximum uncertainty is estimated for the initial controller design in one loop and single-input and single-output (SISO) controller design is applied. This controller is substituted to other equivalent loop for design, and finally, the first loop controller is refined on knowledge of other loop controller. For SISO controller tuning, a new method is presented to determine the achievable gain and phase margins as well as the relevant controller parameters. Examples are given for illustration and comparison.     

3带紧支撑的正交小波

本文首先通过Householder矩阵扩充构造了3带紧支撑的正交小波．当尺度函数具有紧支撑对称正交性时,本文通过仿酉矩阵对称扩充构造了3带紧支撑对称的正交小波,并且研究了所构造对称小波的结构．所构造小波函数的支撑不超过尺度函数的支撑,构造方法容易推广到一般d带的情形．另外,本文还给出了容易实施的显式构造算法．最后,给出了构造算例．     

基于ExtJS技术与SSH框架的权限管理研究

根据政务信息管理的特点,采用基于Ajax的前端开发技术ExtJS和SSH框架的后台技术设计了一个社区管理信息平台.以信息平台中的权限管理系统为例,对系统中使用的ExtJS技术和SSH框架进行了介绍,分析了整个权限管理系统功能结构,并在系统分析和设计中说明了ExtJS树形结构在权限管理系统中的具体应用.ExtJS多级动态树结构实现了AjaX技术异步加载树节点,提高了权限管理系统的实用性和可扩展性.     

Further results of recursive evaluation for compound distribution with the severity distribution of mixed type

Yang et al. [J.P. Yang, S.H. Cheng, Q. Wu, Recursive equations for compound distribution with the severity distribution of the mixed type, Science in China Series A 48 (2005) 594-609] investigated a recursive procedure for a kind of compound distributions with the number of claims belonging to (a,b)-family and the severity distribution of the mixed type. In this paper, we extend their results by assuming that the claim number belongs to a larger class. As applications, the excess-of-loss reinsurance treaty is discussed and concrete examples are considered in some detail.     

基于Mapobjects的双地图窗口的交互查询设计

介绍基于Ｍａｐｏｂｊｅｃｔｓ的双地图窗口的交互查询的设计方法。