Effects of STN DBS on rigidity in Parkinson's disease.

We quantified the effects of deep brain stimulation (DBS) of the subthalamic nucleus (STN) and medication on Parkinsonian rigidity using an objective measure of work about the elbow joint during a complete cycle of imposed 1-Hz sinusoidal oscillations. Resting and activated rigidity were analyzed in four experimental conditions: 1) off treatment; 2) on DBS; 3) on medication; and 4) on DBS plus medication. Rigidity at the elbow joint was also assessed using the Unified Parkinson's Disease Rating Scale (UPDRS). We tested ten patients who received STN DBS and ten age-matched neurologically healthy control subjects. The activated rigidity condition increased work in both Parkinson's disease (PD) patients and control subjects. In PD patients, STN DBS reduced both resting and activated rigidity as indicated by work and the UPDRS rigidity score. This is the first demonstration that STN stimulation reduces rigidity using an objective measure such as work. In contrast, the presurgery dose of antiparkinsonian medication did not significantly improve the UPDRS rigidity score and reduced work only in the activated rigidity condition. Our results suggest that STN DBS may be more effective in alleviating rigidity in the upper limb of PD patients than medications administered at presurgery dosage level.     

An Improved Triggering Method for a High Power Cycloconverter-Induction Motor Drive

A triggering method is discussed which is specifically designed for a traction drive consisting of a high-frequency alternator, a phase-controlled cycloconverter, and an induction motor. Because the motor operates with controlled slip the power-factor characteristics are known, and this is utilized to obtain cycloconverter simplification and to optimize machine sizes. Specific advantages over a conventional phase-controlled cycloconverter are 1) significantly higher alternator power factor, and 2) elimination of interphase reactors and current polarity sensing circuitry. Test results are described for a single cycloconverter-induction motor drive operating from a 420-Hz alternator in both motoring and electrical braking and for two drives operating in parallel from the same alternator. Motor efficiencies are within 1.5 percent of the sine-wave efficiencies and the alternator power factor varies from 0.78 to 0.84 over the motor speed range at full power. Electrical braking was achieved into grid resistors connected to the motor without requiring ``real' power from the alternator. Operation of the two parallel drives from one alternator was successful despite severe alternator voltage distortion.     

Quantitative analysis of harmonic convergence in mosquito auditory interactions

This article analyses the hearing and behaviour of mosquitoes in the context of inter-individual acoustic interactions. The acoustic interactions of tethered live pairs of Aedes aegypti mosquitoes, from same and opposite sex mosquitoes of the species, are recorded on independent and unique audio channels, together with the response of tethered individual mosquitoes to playbacks of pre-recorded flight tones of lone or paired individuals. A time-dependent representation of each mosquito''s non-stationary wing beat frequency signature is constructed, based on Hilbert spectral analysis. A range of algorithmic tools is developed to automatically analyse these data, and used to perform a robust quantitative identification of the ‘harmonic convergence’ phenomenon. The results suggest that harmonic convergence is an active phenomenon, which does not occur by chance. It occurs for live pairs, as well as for lone individuals responding to playback recordings, whether from the same or opposite sex. Male–female behaviour is dominated by frequency convergence at a wider range of harmonic combinations than previously reported, and requires participation from both partners in the duet. New evidence is found to show that male–male interactions are more varied than strict frequency avoidance. Rather, they can be divided into two groups: convergent pairs, typified by tightly bound wing beat frequencies, and divergent pairs, that remain widely spaced in the frequency domain. Overall, the results reveal that mosquito acoustic interaction is a delicate and intricate time-dependent active process that involves both individuals, takes place at many different frequencies, and which merits further enquiry.     

Strategies to obtain pattern fidelity in nanowire growth from large-area surfaces patterned using nanoimprint lithography

Position controlled nanowire growth is important for nanowire-based optoelectronic components which rely on light emission or light absorption. For solar energy harvesting applications, dense arrays of nanowires are needed; however, a major obstacle to obtaining dense nanowire arrays is seed particle displacement and coalescing during the annealing stage prior to nanowire growth. Here, we explore three different strategies to improve pattern preservation of large-area catalyst particle arrays defined by nanoimprint lithography for nanowire growth. First, we see that heat treating the growth substrate prior to nanoimprint lithography improves pattern preservation. Second, we explore the possibility of improving pattern preservation by fixing the seed particles in place prior to annealing by modifying the growth procedure. And third, we show that a SiN _x growth mask can fully prevent seed particle displacement. We show how these strategies allow us to greatly improve the pattern fidelity of grown InP nanowire arrays with dimensions suitable for solar cell applications, ultimately achieving 100% pattern preservation over the sampled area. The generic nature of these strategies is supported through the synthesis of GaAs and GaP nanowires.

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Towards an optimised lab procedure for long-term oxidative ageing of asphalt mix specimen

Ageing of bitumen leads to increased stiffness and brittleness. Thus, bituminous bound pavements become more prone to failure by low-temperature and fatigue cracking. Therefore, the ageing behaviour of bitumen has a crucial impact on durability, as well as recyclability of pavements. To assess ageing of bitumen, the rolling thin film oven test and pressure ageing vessel are standardised methods for short-term and long-term ageing in the lab. For lab-ageing of hot mix asphalt (HMA), various methods have been developed in the last decades. This paper presents a study on the potential of employing a highly oxidant gas for simulating the long-term oxidative ageing of asphalt mix specimens in the lab. Based on the results, an optimised lab-ageing procedure (Viennese Ageing Procedure – VAPro) for compacted HMA specimens to assess mix performance of long-term lab-aged specimens is developed. Thus, it is possible to optimise mix design not only for short-term performance but to take into account effects of oxidative ageing during its in-service life. VAPro is based on a triaxial cell with forced flow of a gaseous oxidant agent through the specimen. The oxidant agent is enriched in ozone and nitric oxides to increase the rate of oxidation. It is shown by stiffness tests of unaged and lab-aged specimens, as well as by Dynamic Shear Rheometer tests of recovered binder from aged specimens that asphalt mixes can be long-term aged at moderate temperatures (+60°C) and within 4 days and a flow rate of 1 l/min by applying VAPro. Thus, an ageing procedure is at hand that can simulate long-term ageing at conditions that are representative of conditions that occur in the field within an efficient amount of time.     

R&D,worker training and innovation: firm-level evidence

Firms that invest in R&D and also in worker training are expected to be successful innovators; yet, the extent to which these investments are mutually reinforcing has not been established. This paper addresses that question by analysing the decision to innovate and the number of innovations introduced. Our findings, which are based on a sample of Spanish manufacturing firms, confirm that R&D is more effective when firms also invest in worker training. Moreover, for some smaller firms, investing in workers’ skills (via training programs) boosts innovation even in absence of R&D. Meanwhile, on-the-job training in large firms might serve mainly to reinforce the effects of R&D. Regarding the number of innovations, our result signals that a higher absorptive capacity via higher ability of qualified workers (through schooling or training) leads to improved innovation performance.     

Sketch‐to‐Design: Context‐Based Part Assembly

Designing 3D objects from scratch is difficult, especially when the user intent is fuzzy and lacks a clear target form. We facilitate design by providing reference and inspiration from existing model contexts. We rethink model design as navigating through different possible combinations of part assemblies based on a large collection of pre‐segmented 3D models. We propose an interactive sketch‐to‐design system, where the user sketches prominent features of parts to combine. The sketched strokes are analysed individually, and more importantly, in context with the other parts to generate relevant shape suggestions via adesign galleryinterface. As a modelling session progresses and more parts get selected, contextual cues become increasingly dominant, and the model quickly converges to a final form. As a key enabler, we use pre‐learned part‐based contextual information to allow the user to quickly explore different combinations of parts. Our experiments demonstrate the effectiveness of our approach for efficiently designing new variations from existing shape collections.