Curved finite elements for the analysis of shallow and deep arches

The paper considers the analysis of shallow and deep arches by curved beam finite elements, the interest in this problem being that it forms a limiting case of the shell problem. The individual elements are assumed to be shallow with respect to a local base line and different types of strain-displacement equations are utilised. Particular attention is focussed on the choice of the displacement patterns for the elements and models based both on independently-interpolated displacement components, of up to quintic order, and on assumed strain distributions are considered. Numerical applications using the various models show that of those tested only quintic-quintic models and assumed-strain models are generally satisfactory.     

Vibration analysis of rectangular mindlin plates by the finite strip method

A finite strip analysis of the vibration of rectangular Mindlin plates with general boundary conditions is described. The normal modes of vibration of Timoshenko beams are used to represent the spatial variation along a strip of the deflection and the two cross-sectional rotations. For the crosswise representation equal-order polynomial interpolation is employed for each of these three basic quantities. The accuracy of the approach is demonstrated by the results of a number of applications to square plates with combinations of simply supported, clamped and free edges.     

Buckling of rectangular mindlin plates

The elastic buckling of rectangular Mindlin plates is considered using two related methods of analysis. These methods are the Rayleight-Ritz method and one of its piece-wise forms, the finite strip method. Arbitrary combinations of the standard boundary conditions of clamped, simply-supported and free edges are accommodated by the use in the assumed displacement fields of the normal modes of vibration of Timoshenko beams. The applied membrane stress field leading to buckling can comprise biaxial direct stress plus shear stress. A range of numerical applications is described for isotropic and transversely isotropic plates of thin and moderately thick geometry. The results obtained using the two methods compare closely to one another and to other published results where these are available. A direct relationship between unidirectional buckling stress and frequency of vibration is demonstrated for a category of plates having one pair of opposite edges simply supported.     

The photosensitivity dermatitis and actinic reticuloid syndrome (chronic actinic dermatitis) occurring in seven young atopic dermatitis patients

This study describes the translocation of the brain specific protein kinase C gamma isoenzyme (PKCgamma) in the hippocampus during food rewarded spatial learning. The holeboard test was used for spatial orientation, and immunoblot analysis was used for assessment of PKCgamma in cytosolic, membrane-inserted and membrane-associated fractions. Membrane-associated PKCgamma was increased during early acquisition of spatial learning, but not in a later phase of training. This transient and apparently temporary intracellular PKCgamma translocation was only observed in the posterior but not in the anterior hippocampus, and was only detected within 10 min after termination of the learning trial. This study supports the idea that PKCgamma is significantly involved in the biochemical events underlying learning and memory, notably during the period of novel information processing. The results further promote the hypothesis that the hippocampus is specifically involved in temporal information processing, which requires the engagement of PKCgamma.     

A Flexi-PEGDA Upconversion Implant for Wireless Brain Photodynamic Therapy

Near-infrared (NIR) activatable upconversion nanoparticles (UCNPs) enable wireless-based phototherapies by converting deep-tissue-penetrating NIR to visible light. UCNPs are therefore ideal as wireless transducers for photodynamic therapy (PDT) of deep-sited tumors. However, the retention of unsequestered UCNPs in tissue with minimal options for removal limits their clinical translation. To address this shortcoming, biocompatible UCNPs implants are developed to deliver upconversion photonic properties in a flexible, optical guide design. To enhance its translatability, the UCNPs implant is constructed with an FDA-approved poly(ethylene glycol) diacrylate (PEGDA) core clad with fluorinated ethylene propylene (FEP). The emission spectrum of the UCNPs implant can be tuned to overlap with the absorption spectra of the clinically relevant photosensitizer, 5-aminolevulinic acid (5-ALA). The UCNPs implant can wirelessly transmit upconverted visible light till 8 cm in length and in a bendable manner even when implanted underneath the skin or scalp. With this system, it is demonstrated that NIR-based chronic PDT is achievable in an untethered and noninvasive manner in a mouse xenograft glioblastoma multiforme (GBM) model. It is postulated that such encapsulated UCNPs implants represent a translational shift for wireless deep-tissue phototherapy by enabling sequestration of UCNPs without compromising wireless deep-tissue light delivery.     

大速比多项作业车辆采用一种牵引弧锥环轮式无级变速传动和牵引行星传动的变速箱

采用一牵引无级变速传动和一行星牵引定速比传动的一种新型变速箱已经设计、研制与试验。本文将以功率流概念和新部件结构两方面来描述这种变速箱的设计。把这种无级变速传动和行星传动综合成一体，可以据此由三个功率流实现总速比２０∶１以上的大无级变速范围。不加其他设备可实现空档与倒档。该变速箱已装于０．５ｔ轻型货车做大速比车辆变速箱有关试验。     

Finite strip buckling and free vibration analysis of stepped rectangular composite laminated plates

A general spline finite strip method is presented which allows the spline knots to be located arbitrarily along the plate strip and also facilitates the use of analytical integration in evaluating strip properties. The development takes place in the contexts of first‐order shear deformation plate theory and of classical plate theory, and encompasses composite laminated material. The prediction of natural frequencies and buckling stresses of stepped rectangular plates is considered using the new approach in which refinement of knot spacings is used local to a step change. The superstrip concept is used as part of an efficient solution procedure. A number of applications demonstrate the validity and practicability of the developed method. Copyright © John Wiley & Sons, Ltd.     

A Large Potential Methane Source—Natural Gas Hydrates

Abstract

Natural gas, essentially methane, can be obtained from natural gas hydrate (NGH). NGH reserves are difficult to pinpoint in the subsurface, but large sources have been identified by seismic reflection. This is particularly so below the sea floor near continental shelf plates in the oceans deeper than 300 m as NGH is stable at 4°C and 50 bar pressure. When extracted, 1 m³ of NGH can contain 160 sm³ of gas. Currently, estimates of this gas resource are very uncertain, but recent estimates suggest perhaps 2,500 trillion sm³, but how much gas can actually be produced from these accumulations is totally unclear at present. NGH could possibly solve much of the energy needs after 2020, but safe ways of extraction still have to be designed. Possible methods include the injection of hot water or inhibitor or reduction of reservoir pressure, but none have yet been commercially tested. Great caution will be needed because catastrophic environmental damage is likely if the methane is carelessly released from the sediments. This article reviews the ‘state of the art’ of NGH.     

Experimental Studies of the Effects of Permeability Variations on Immiscible Flow

Abstract

The properties of hydrocarbon reservoirs are generally derived from core experiments and use theories of fluid flow that normally assume homogeneous core properties. Reservoirs, however, are generally heterogeneous, and interpretations of the results of these experiments are likely to be unreliable if the core from which the data are derived is heterogeneous. This article examines experimentally immiscible displacement through well-defined permeability heterogeneities, modeled using 2-D visual models packed with clear beads of different permeabilities.

The results indicated that the displacement patterns were dominated by capillary pressure effects and that they were different from those found in miscible systems. This understanding is needed, since in reservoir simulators, the simulator codes must contain the correct physics, and in core analysis, the effluent profiles must be correctly interpreted for sensible predictions.