AZ31B镁合金/镀锌钢板电阻点焊接头形成机理

针对2.0 mm厚的AZ31B镁合金以及1.0 mm厚的SPHC镀锌钢板,采用KDWJ-17型三相次级整流电阻焊机进行焊接试验,通过光学金相、扫描电镜等方法分析接头各区域的组织结构和成分分布.提出了镁锌低熔点化合物挤压机制,分析了Zn元素在镁合金和镀锌钢板电阻点焊中的作用.结果表明,Zn与Mg元素形成的低熔点化合物MgZn₂在电极压力的作用下能填满由于焊接变形引起的间隙,使反应界面密封,促进Fe,Al元素在界面发生处扩散,Fe与Al元素在界面处发生反应生成Fe₂Al₅化合物,从而形成高强度的镁合金与镀锌钢板的电阻点焊接头.     

A study of surface topography, friction and lubricants in metalforming

In this paper are presented the results of investigations concerning the relation between friction behaviour and surface topography using various lubricants and initial workpiece surface conditions in ring upsetting and rod extrusion processes. The tests were carried out using either a liquid lubricant or under clean dry conditions. Two types of workpiece surfaces, random and directional, were prepared by either shotblasting, or EDM or turning to different levels of surface finish. Not only has the friction effect of lubricant and initial surface been studied, but also the surface topography of the finished products has been examined in detail, to obtain a better understanding of the mechanism of lubrication and surface interaction. It was found that, for random surfaces, smoother ones could retain more lubricant and decrease friction resistance. The experimentation also demonstrated that turned surfaces were effective in reducing friction, but the final surface finish of the workpiece was not as good as that from random surfaces.     

数学史上的三次重大危机

在教学发展史上,无理数的出现,无穷小量以及集合悖论的困惑,引起人们极大的混乱,给数学的发展以深刻的影响,俗称数学史上的三次重大危机。依据历史事实研究它们产生和突破的过程,从中分析理论和实践的关系,数学与逻辑的关系,运用唯物辩证法来指导数学的教学与研究工作。     

V形坡口和K形坡口Q345/SUS304异种钢对接接头残余应力和变形

以ABAQUS软件为平台,开发热-弹-塑性有限元方法模拟了V形坡口和K形坡口Q345/SUS304异种钢多层焊对接接头的温度场、残余应力和焊接变形.同时采用试验的方法测量了接头的残余应力和角变形.计算结果与试验测量结果吻合良好,验证了计算方法的妥当性.数值结果表明,不同坡口Q345/SUS304异种钢接头的Q345母材与焊缝交界处的应力分布均出现不连续性,且SUS304侧的高拉伸残余应力区明显宽于Q345侧;K形坡口开口朝向Q345侧相较于开口朝向SUS304侧的接头,Q345/焊缝交界处附近的峰值应力和高拉伸残余应力区均明显较小.试验和数值结果表明,坡口形式对接头的角变形有明显的影响.     

基于伺服电机的焊机进给系统

电阻单面凸焊作为一种重要的焊接工艺方法,已广泛应用于航空、航天、汽车制造、电子技术等工业领域。为了实现对电阻单面凸焊进给系统的精确控制,提高电阻单面凸焊的生产效率、减轻工人的劳动强度及确保工人的生命安全,以STM32系列单片机为控制器,将伺服电机用于焊接机床的进给系统,合理的设计系统的软件和硬件,以期方便而又稳定地控制机床进给,实现焊接机床的自动化。介绍了该控制系统的总体方案、系统硬件构成和软件总体框图。     

Development and Characterization of a Multiplex Assay to Quantify Complement-Fixing Antibodies against Dengue Virus

Antibodies capable of activating the complement system (CS) when bound with antigen are referred to as “complement-fixing antibodies” and are involved in protection against Flaviviruses. A complement-fixing antibody test has been used in the past to measure the ability of dengue virus (DENV)-specific serum antibodies to activate the CS. As originally developed, the test is time-consuming, cumbersome, and has limited sensitivity for DENV diagnosis. Here, we developed and characterized a novel multiplex anti-DENV complement-fixing assay based on the Luminex platform to quantitate serum antibodies against all four serotypes (DENV1-4) that activate the CS based on their ability to fix the complement component 1q (C1q). The assay demonstrated good reproducibility and showed equivalent performance to a DENV microneutralization assay that has been used to determine DENV serostatus. In non-human primates, antibodies produced in response to primary DENV1-4 infection induced C1q fixation on homologous and heterologous serotypes. Inter-serotype cross-reactivity was associated with homology of the envelope protein. Interestingly, the antibodies produced following vaccination against Zika virus fixed C1q on DENV. The anti-DENV complement fixing antibody assay represents an alternative approach to determine the quality of functional antibodies produced following DENV natural infection or vaccination and a biomarker for dengue serostatus, while providing insights about immunological cross-reactivity among different Flaviviruses.     

Transcriptional Modulation of the Hippo Signaling Pathway by Drugs Used to Treat Bipolar Disorder and Schizophrenia

Recent reports suggest a link between positive regulation of the Hippo pathway with bipolar disorder (BD), and the Hippo pathway is known to interact with multiple other signaling pathways previously associated with BD and other psychiatric disorders. In this study, neuronal-like NT2 cells were treated with amisulpride (10 µM), aripiprazole (0.1 µM), clozapine (10 µM), lamotrigine (50 µM), lithium (2.5 mM), quetiapine (50 µM), risperidone (0.1 µM), valproate (0.5 mM), or vehicle control for 24 h. Genome-wide mRNA expression was quantified and analyzed using gene set enrichment analysis (GSEA), with genes belonging to Hippo, Wnt, Notch, TGF- β, and Hedgehog retrieved from the KEGG database. Five of the eight drugs downregulated the genes of the Hippo pathway and modulated several genes involved in the interacting pathways. We speculate that the regulation of these genes, especially by aripiprazole, clozapine, and quetiapine, results in a reduction of MAPK and NFκB pro-inflammatory signaling through modulation of Hippo, Wnt, and TGF-β pathways. We also employed connectivity map analysis to identify compounds that act on these pathways in a similar manner to the known psychiatric drugs. Thirty-six compounds were identified. The presence of antidepressants and antipsychotics validates our approach and reveals possible new targets for drug repurposing.     

Induction of Tertiary Phase Epileptiform Discharges after Postasphyxial Infusion of a Toll-Like Receptor 7 Agonist in Preterm Fetal Sheep

Background: Toll-like receptor (TLR) agonists are key immunomodulatory factors that can markedly ameliorate or exacerbate hypoxic–ischemic brain injury. We recently demonstrated that central infusion of the TLR7 agonist Gardiquimod (GDQ) following asphyxia was highly neuroprotective after 3 days but not 7 days of recovery. We hypothesize that this apparent transient neuroprotection is associated with modulation of seizure-genic processes and hemodynamic control. Methods: Fetuses received sham asphyxia or asphyxia induced by umbilical cord occlusion (20.9 ± 0.5 min) and were monitored continuously for 7 days. GDQ 3.34 mg or vehicle were infused intracerebroventricularly from 1 to 4 h after asphyxia. Results: GDQ infusion was associated with sustained moderate hypertension that resolved after 72 h recovery. Electrophysiologically, GDQ infusion was associated with reduced number and burden of postasphyxial seizures in the first 18 h of recovery (p < 0.05). Subsequently, GDQ was associated with induction of slow rhythmic epileptiform discharges (EDs) from 72 to 96 h of recovery (p < 0.05 vs asphyxia + vehicle). The total burden of EDs was associated with reduced numbers of neurons in the caudate nucleus (r² = 0.61, p < 0.05) and CA1/2 hippocampal region (r² = 0.66, p < 0.05). Conclusion: These data demonstrate that TLR7 activation by GDQ modulated blood pressure and suppressed seizures in the early phase of postasphyxial recovery, with subsequent prolonged induction of epileptiform activity. Speculatively, this may reflect delayed loss of early protection or contribute to differential neuronal survival in subcortical regions.