Reading aloud: Qualitative differences in the relation between stimulus quality and word frequency as a function of context.

Virtually all theories of visual word recognition assume (typically implicitly) that when a pathway is used, processing within that pathway always unfolds in the same way. This view is challenged by the observation that simple variations in list composition are associated with qualitative changes in performance. The present experiments demonstrate that when reading aloud, the joint effects of stimulus quality and word frequency on response time are driven by the presence/absence of nonwords in the list. Interacting effects of these factors are seen when only words appear in the experiment, whereas additive effects are seen when words and nonwords are randomly intermixed. One way to explain these and other data appeals to the distinction between cascaded processing (or interactive activation) on the one hand versus a thresholded mode of processing on the other, with contextual factors determining which mode of processing dominates. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Health and illness: the definition of the World Health Organization

Ethik in der Medizin -     

Separation of a Nonstationary Component from the EEG by a Nonlinear Digital Filter

A new nonlinear digital filter which separates nonstationary waves such as spikes from stationary background waves of the EEG is proposed. This filter is composed of a prediction filter and a simple nonlinear function. Some examples showing the separation of spikes from EEG data of epileptic patients are given.     

Synthetic and Biological Studies of Sesquiterpene Polygodial: Activity of 9‐Epipolygodial against Drug‐Resistant Cancer Cells

Polygodial, a terpenoid dialdehyde isolated from Polygonum hydropiper L., is a known agonist of the transient receptor potential vanilloid 1 (TRPV1). In this investigation a series of polygodial analogues were prepared and investigated for TRPV1‐agonist and anticancer activities. These experiments led to the identification of 9‐epipolygodial, which has antiproliferative potency significantly exceeding that of polygodial. 9‐Epipolygodial was found to maintain potency against apoptosis‐resistant cancer cells as well as those displaying the multidrug‐resistant (MDR) phenotype. In addition, the chemical feasibility for the previously proposed mechanism of action of polygodial, involving the formation of a Paal–Knorr pyrrole with a lysine residue on the target protein, was demonstrated by the synthesis of a stable polygodial pyrrole derivative. These studies reveal rich chemical and biological properties associated with polygodial and its direct derivatives. These compounds should inspire further work in this area aimed at the development of new pharmacological agents, or the exploration of novel mechanisms of covalent modification of biological molecules with natural products.     

Synthesis and Biological Evaluation of Novel Epothilone B Side Chain Analogues

The design, synthesis, and biological evaluation of a series of epothilone analogues with novel side chains equipped with an amino group are described. Their design facilitates potential conjugation to selective drug delivery systems such as antibodies. Their synthesis proceeded efficiently via Stille coupling of a readily available vinyl iodide and heterocyclic stannanes. Cytotoxicity studies and tubulin binding assays revealed two of these analogues to be more potent than epothilones A–D and the anticancer agent ixabepilone, currently in clinical use.     

Coupled mechanical and chemical processes in engineered geothermal reservoirs with dynamic permeability

A model is developed to represent mechanical strain, stress-enhanced dissolution, and shear dilation as innately hysteretic and interlinked processes in rough contacting fractures. The model is incorporated into a numerical simulator designed to examine permeability change and thermal exchange in chemically active and deformable fractured reservoirs. A candidate engineered geothermal reservoir system (EGS) is targeted. The mechanistic model is able to distinguish differences between the evolution of fluid transmission characteristics of (1) small scale, closely spaced fractures, and (2) large-scale, more widely spaced fractures. Alternate realizations of fracture frequency and scale, exhibiting identical initial bulk permeability, lead to significantly different conclusions regarding permeability evolution and thermal drawdown within the reservoir. Reactivation, primarily through mechanical shear, of pervasive, large-scale fractures is shown capable of causing both hydraulic and thermal short circuiting. Small variations in fracture scale impact the balance between the efficiency of thermal transfer and the rate of fluid circulation. Stress-enhanced chemical dissolution, initially at equilibrium within the reservoir, may be reactivated as fractures are forced out of equilibrium during hydraulic fracturing. At the conditions examined (250 °C reservoir with 70 °C injection), however, shear dilation exerts dominant control over changes to permeability. Heterogeneity in permeability, generated from a normal distribution of fracture spacing, impacts thermal breakthrough times at the withdrawal well, as well as withdrawal rates. For the given conditions, spatial variability over ～1 order of magnitude leads to a reduction of ～10% in withdrawal rates compared to a spatially uniform system. Permeability is a strongly dynamic property and at geothermal conditions is influenced by the full suite of THMC interactions.     

Perfluorinated acids in Arctic snow: new evidence for atmospheric formation

Perfluorinated acids (PFAs) are ubiquitously found in water and biota, including remote regions such as the High Arctic. Under environmental conditions, PFAs exist mainly as anions and are not expected to be subject to long-range atmospheric transport in the gas phase. Fluorinated telomer alcohols (FTOHs) are volatile and can be atmospherically oxidized to form perfluorocarboxylic acids. Analogously, fluorosulfamido alcohols can be oxidized to form perfluorooctane sulfonate (PFOS). High Arctic ice caps experience contamination solely from atmospheric sources. By examining concentrations of PFAs in ice cap samples, it is possible to determine atmospheric fluxes to the Arctic. Ice samples were collected from high Arctic ice caps in the spring of 2005 and 2006. Samples were concentrated using solid-phase extraction and analyzed by LC-MS-MS. PFAs were observed in all samples, dating from 1996 to 2005. Concentrations were in the low-mid pg L(-1) range and exhibited seasonality, with maximum concentrations in the spring-summer. The presence of perfluorodecanoic acid (PFDA) and perfluoroundecanoic acid (PFUnA) on the ice cap was indicative of atmospheric oxidation as a source. Ratios of PFAs to sodium concentrations were highly variable, signifying PFA concentrations on the ice cap were unrelated to marine chemistry. Fluxes of the PFAs were estimated to the area north of 65 degrees N for the 2005 season, which ranged from 114 to 587 kg year(-1) for perfluorooctanoic acid (PFOA), 73 to 860 kg year(-1) for perfluorononanoic acid (PFNA), 16 to 84 kg year(-1) for PFDA, 26 to 62 kg year(-1) for PFUnA, and 18 to 48 kg year(-1) for PFOS. The PFOA and PFNA fluxes agreed with FTOH modeling estimations. A decrease in PFOS concentrations through time was observed, suggesting a fast response to changes in production. These data suggest that atmospheric oxidation of volatile precursors is a primary source of PFAs to the Arctic.     

专家问答一一IEC60335问题解答（9）

问：机19．11测试电子线路。双重故障测试如何要求？答：如果一个保护电子电路是用于提供安全性的,在这种情况下,IEC60335—1中的19．11．3条是适用的。     

Koko: an architecture for affect-aware games

The importance of affect in delivering engaging experiences in entertainment and educational games is well recognized. Yet, current techniques for building affect-aware games are limited, with the maintenance and use of affect in essence being handcrafted for each game. The Koko architecture describes a service-oriented middleware that reduces the burden of incorporating affect recognition into games, thereby enabling developers to concentrate on the functional and creative aspects of their applications. The Koko architecture makes three key contributions: (1) improving developer productivity by creating a reusable and extensible environment; (2) yielding an enhanced user experience by enabling independently developed games and other applications to collaborate and provide a more coherent user experience than currently possible; (3) enabling affective communication in multiplayer and social games. Further, Koko is intended to be used as an extension of existing game architectures. We recognize that complex games require additional third party libraries, such as game engines. To enable the required flexibility we define the interfaces of the Koko architecture in a formal manner, thereby enabling the implementation of those interfaces to readily adapt to the unique requirements of game’s other architectural components and requirements.