全文获取类型
收费全文 | 1479篇 |
免费 | 66篇 |
国内免费 | 7篇 |
专业分类
电工技术 | 19篇 |
综合类 | 6篇 |
化学工业 | 274篇 |
金属工艺 | 26篇 |
机械仪表 | 21篇 |
建筑科学 | 97篇 |
矿业工程 | 1篇 |
能源动力 | 74篇 |
轻工业 | 223篇 |
水利工程 | 12篇 |
石油天然气 | 4篇 |
无线电 | 68篇 |
一般工业技术 | 207篇 |
冶金工业 | 246篇 |
原子能技术 | 12篇 |
自动化技术 | 262篇 |
出版年
2023年 | 9篇 |
2022年 | 14篇 |
2021年 | 25篇 |
2020年 | 21篇 |
2019年 | 28篇 |
2018年 | 40篇 |
2017年 | 39篇 |
2016年 | 36篇 |
2015年 | 28篇 |
2014年 | 47篇 |
2013年 | 92篇 |
2012年 | 77篇 |
2011年 | 91篇 |
2010年 | 68篇 |
2009年 | 71篇 |
2008年 | 91篇 |
2007年 | 99篇 |
2006年 | 77篇 |
2005年 | 56篇 |
2004年 | 55篇 |
2003年 | 48篇 |
2002年 | 41篇 |
2001年 | 27篇 |
2000年 | 21篇 |
1999年 | 21篇 |
1998年 | 14篇 |
1997年 | 13篇 |
1996年 | 18篇 |
1995年 | 16篇 |
1994年 | 26篇 |
1993年 | 20篇 |
1992年 | 23篇 |
1991年 | 10篇 |
1990年 | 11篇 |
1989年 | 5篇 |
1988年 | 7篇 |
1987年 | 16篇 |
1986年 | 15篇 |
1985年 | 21篇 |
1984年 | 12篇 |
1983年 | 19篇 |
1982年 | 10篇 |
1981年 | 16篇 |
1980年 | 13篇 |
1979年 | 6篇 |
1978年 | 5篇 |
1977年 | 6篇 |
1976年 | 5篇 |
1975年 | 9篇 |
1974年 | 4篇 |
排序方式: 共有1552条查询结果,搜索用时 78 毫秒
41.
Smithwick M Norstrom RJ Mabury SA Solomon K Evans TJ Stirling I Taylor MK Muir DC 《Environmental science & technology》2006,40(4):1139-1143
Perfluoroalkyl substances are globally distributed anthropogenic contaminants. Their production and use have increased dramatically from the early 1980s. While many recent publications have reported concentrations of perfluorooctane sulfonate (PFOS) and other perfluoroalkyl acids (PFAs) in biotic and abiotic samples, only limited work has addressed temporal trends. In this study we analyzed archived polar bear(Ursus maritimus) livertissue samples from two geographic locations in the North American Arctic, collected from 1972 to 2002. The eastern group, taken from the vicinity of northern Baffin Island, Canada, comprised 31 samples, and the western group, from the vicinity of Barrow, Alaska, comprised 27 samples. Samples were analyzed for perfluorocarboxylic acids (PFCAs) from carbon chain length C8 to C15, perfluorohexane sulfonate, PFOS, the neutral precursor perfluorooctane sulfonamide (PFOSA), as well as 8:2 and 10:2 fluorotelomer acids and their alpha,beta unsaturated acid counterparts. Concentrations of PFOS and PFCAs with carbon chain lengths from C9 to C11 showed an exponential increase between 1972 and 2002 at both locations. Doubling times ranged from 3.6 +/- 0.9 years for perfluorononanoic acid in the eastern group to 13.1 +/- 4.0 years for PFOS in the western group. PFOSA showed decreasing concentrations over time at both locations, while the remaining PFAs showed no significant trends or were not detected in any sample. The doubling time for PFOS was similar to the doubling time of production of perfluoroctylsulfonyl-fluoride-based products during the 1990s. 相似文献
42.
Biological monitoring of polyfluoroalkyl substances: A review 总被引:2,自引:0,他引:2
Houde M Martin JW Letcher RJ Solomon KR Muir DC 《Environmental science & technology》2006,40(11):3463-3473
Polyfluoroalkyl substances (PFSs) are used in industrial and commercial products and can degrade to persistent perfluorocarboxylates (PFCAs) and perfluoroalkyl sulfonates (PFSAs). Temporal trend studies using human, fish, bird, and marine mammal samples indicate that exposure to PFSs has increased significantly over the past 15-25 years. This review summarizes the biological monitoring of PFCAs, PFSAs, and related PFSs in wildlife and humans, compares concentrations and contamination profiles among species and locations, evaluatesthe bioaccumulation/biomagnification in the environment, discusses possible sources, and identifies knowledge gaps. PFSs can reach elevated concentrations in humans and wildlife inhabiting industrialized areas of North America, Europe, and Asia (2-30,000 ng/ mL or ng/g of wet weight (ww)). PFSs have also been detected in organisms from the Arctic and mid-ocean islands (< or = 3000 ng/g ww). In humans, PFSAs and PFCAs have been shown to vary among ethnic groups and PFCA/PFSA profiles differ from those in wildlife with high proportions of perfluorooctanoic acid and perfluorooctane sulfonate. The pattern of contamination in wildlife varied among species and locations suggesting multiple emission sources. Food web analyses have shown that PFCAs and PFSAs can bioaccumulate and biomagnify in marine and freshwater ecosystems. Knowledge gaps with respect to the transport, accumulation, biodegradation, temporal/spatial trends and PFS precursors have been identified. Continuous monitoring with key sentinel species and standardization of analytical methods are recommended. 相似文献
43.
Biomagnification of perfluoroalkyl compounds in the bottlenose dolphin (Tursiops truncatus) food web 总被引:2,自引:0,他引:2
Houde M Bujas TA Small J Wells RS Fair PA Bossart GD Solomon KR Muir DC 《Environmental science & technology》2006,40(13):4138-4144
The environmental distribution and the biomagnification of a suite of perfluoroalkyl compounds (PFCs), including perfluorooctane sulfonate (PFOS) and C8 to C14 perfluorinated carboxylates (PFCAs), was investigated in the food web of the bottlenose dolphin (Tursiops truncatus). Surficial seawater and sediment samples, as well as zooplankton, fish, and bottlenose dolphin tissue samples, were collected at two U.S. locations: Sarasota Bay, FL and Charleston Harbor, SC. Wastewater treatment plant (WWTP) effluents were also collected from the Charleston area (n = 4). A solid-phase extraction was used for seawater and effluent samples and an ion-pairing method was used for sediment and biotic samples. PFCs were detected in seawater (range <1-12 ng/L), sediment (range <0.01-0.4 ng/g wet weight (ww)), and zooplankton (range 0.06-0.3 ng/g ww). The highest PFC concentrations were detected in WWTP effluents, whole fish, and dolphin plasma and tissue samples in which PFOS, C8 and C10-PFCAs predominated in most matrices. Contamination profiles varied with location suggesting different sources of PFC emissions. Biomagnification factors (BMFs) ranged from <1 to 156 at Sarasota Bay and <1 to 30 at Charleston. Trophic magnification factors (TMFs) for PFOS and C8-C11 PFCAs indicated biomagnification in this marine food web. The results indicate that using plasma and liver PFC concentrations as surrogate to whole body burden in a top marine predator overestimates the BMFs and TMFs. 相似文献
44.
Evaluating p97 Inhibitor Analogues for Potency against p97–p37 and p97–Npl4–Ufd1 Complexes 下载免费PDF全文
Dr. Lin Gui Dr. Xiaoyi Zhang Dr. Kelin Li Dr. Kevin J. Frankowski Dr. Shan Li Daniel E. Wong Derek R. Moen Patrick R. Porubsky Dr. Henry J. Lin Dr. Frank J. Schoenen Dr. Tsui‐Fen Chou 《ChemMedChem》2016,11(9):953-957
We previously found that the p97 cofactor, p47, significantly decreased the potency of some ATP‐competitive p97 inhibitors such as ML240 [2‐(2‐amino‐1H‐benzo[d]imidazol‐1‐yl)‐N‐benzyl‐8‐methoxyquinazolin‐4‐amine] and ML241 [2‐(2H‐benzo[b][1,4]oxazin‐4(3H)‐yl)‐N‐benzyl‐5,6,7,8 tetrahydroquinazolin‐4‐amine]. In this study, we aimed to evaluate inhibitor potencies against two additional p97 cofactor complexes, p97–p37 and p97–Npl4–Ufd1. We focused on these two cofactor complexes, because the protein sequence of p37 is 50 % identical to that of p47, and the Npl4–Ufd1 heterodimer (NU) is the most‐studied p97 cofactor complex. We screened 200 p97 inhibitor analogues for their ability to inhibit the ATPase activity of p97 alone and of p97–p37 and p97–NU complexes. In contrast to the effect of p47, p37 and NU did not significantly change the potencies of most of the compounds. These results highlight differences among p97 cofactors in influencing p97 conformation and effects of inhibitors on p97 complexes, as compared to p97 alone. Continued efforts are needed to advance the development of complex‐specific p97 inhibitors. 相似文献
45.
Synthetic and Biological Studies of Sesquiterpene Polygodial: Activity of 9‐Epipolygodial against Drug‐Resistant Cancer Cells 下载免费PDF全文
Dr. Ramesh Dasari Annelise De Carvalho Derek C. Medellin Kelsey N. Middleton Dr. Frédéric Hague Marie N. M. Volmar Prof. Liliya V. Frolova Dr. Mateus F. Rossato Jorge J. De La Chapa Nicholas F. Dybdal‐Hargreaves Akshita Pillai Prof. Véronique Mathieu Prof. Snezna Rogelj Prof. Cara B. Gonzales Prof. João B. Calixto Prof. Antonio Evidente Dr. Mathieu Gautier Dr. Gnanasekar Munirathinam Prof. Rainer Glass Prof. Patricia Burth Dr. Stephen C. Pelly Prof. Willem A. L. van Otterlo Prof. Robert Kiss Prof. Alexander Kornienko 《ChemMedChem》2015,10(12):2014-2026
Polygodial, a terpenoid dialdehyde isolated from Polygonum hydropiper L., is a known agonist of the transient receptor potential vanilloid 1 (TRPV1). In this investigation a series of polygodial analogues were prepared and investigated for TRPV1‐agonist and anticancer activities. These experiments led to the identification of 9‐epipolygodial, which has antiproliferative potency significantly exceeding that of polygodial. 9‐Epipolygodial was found to maintain potency against apoptosis‐resistant cancer cells as well as those displaying the multidrug‐resistant (MDR) phenotype. In addition, the chemical feasibility for the previously proposed mechanism of action of polygodial, involving the formation of a Paal–Knorr pyrrole with a lysine residue on the target protein, was demonstrated by the synthesis of a stable polygodial pyrrole derivative. These studies reveal rich chemical and biological properties associated with polygodial and its direct derivatives. These compounds should inspire further work in this area aimed at the development of new pharmacological agents, or the exploration of novel mechanisms of covalent modification of biological molecules with natural products. 相似文献
46.
Kevin J. Schreader Ilker S. Bayer Derek J. Milner Eric Loth Iwona Jasiuk 《应用聚合物科学杂志》2013,127(6):4974-4982
A novel polyurethane‐based foam‐like adhesive reinforced with nanosized hydroxyapatite (HA) particles was developed and investigated for bone‐to‐bone bonding applications in terms of mechanical adhesion and biocompatibility. The adhesive has a hierarchical structure with HA particles at the nanoscale level and pores at the micro‐scale level. This adhesive was tested mechanically in the three principal loading modes anticipated: shear, tension, and compression. Standard testing procedures were used when available. Tensile strength of primed adhesive showed a four‐fold increase in adhesion on unmodified bone and a nearly two‐fold increase in adhesion to primed bone as compared with the conventional bone cement. Biocompatibility was initially assessed in vitro using cell culture tests, which showed positive interaction with the adhesive. Then, a second biocompatibility test was performed using Xenopus laevis limbs to assess an in vivo response. The results indicated that the adhesive material produces a normal response consistent with control specimens. However, long‐term observations and tests with additional species are needed to demonstrate full biocompatibility. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2013 相似文献
47.
48.
Smithwick M Mabury SA Solomon KR Sonne C Martin JW Born EW Dietz R Derocher AE Letcher RJ Evans TJ Gabrielsen GW Nagy J Stirling I Taylor MK Muir DC 《Environmental science & technology》2005,39(15):5517-5523
Perfluoroalkyl substances were determined in liver tissues and blood of polar bears (Ursus maritimus) from five locations in the North American Arctic and two locations in the European Arctic. Concentrations of perfluorooctane sulfonate (PFOS), perfluorohexane sulfonate, heptadecafluorooctane sulfonamide, and perfluoroalkyl carboxylates with C(8)-C(15) perfluorinated carbon chains were determined using liquid chromatography tandem mass spectrometry. PFOS concentrations were significantly correlated with age at four of seven sampling locations, while gender was not correlated to concentration for any compound measured. Populations in South Hudson Bay (2000-2730 ng/g wet wt), East Greenland (911-2140 ng/g wet wt), and Svalbard (756-1290 ng/g wet wt) had significantly (P < 0.05) higher PFOS concentrations than western populations such as the Chukchi Sea (435-729 ng/g wet wt). Concentrations of perfluorocarboxylic acids (PFCAs) with adjacent chain lengths (i.e., C9:C10 and C10:C11) were significantly correlated (P < 0.05), suggesting PFCAs have a common source within a location, but there were differences in proportions of PFCAs between eastern and western location sources. Concentrations of PFOS in liver tissue at five locations were correlated with concentrations of four polychlorinated biphenyl congeners (180, 153, 138, and 99) in adipose tissue of bears in the same populations, suggesting similar transport pathways and source regions of PFOS or precursors. 相似文献
49.
In a highly competitive market, reliable techniques for manufacturing quality control of electronic devices are demanded. Characterisation of modern microelectronic package integrity becomes more difficult due to the continued miniaturisation of electronic device and the complexity of advanced micro-assembling technologies such as chip-scale packages and 3D IC stacks. In this paper, sparse representations of acoustic signals are sought to improve the scanning acoustic microscopy (SAM), a common non-destructive tool for failure analysis of microelectronic packages. Sparse representation of an ultrasonic signal is obtained by decomposing it in an overcomplete dictionary. Detection and location of ultrasonic echoes are then performed on the basis of the resulting redundant representation. The method offers a solution to the deconvolution problem for restoration of the ultrasonic reflectivity function. It can restore closely space overlapping echoes beyond the resolution of the conventional SAM system. It also produces high resolution and accurate estimates for ultrasonic echo parameters, i.e., time-of-flight, amplitude, centre frequency, and bandwidth. These merits of the proposed method are explored in various potential applications for microelectronic package characterisation. 相似文献
50.
Derek Hao Zhi-gang Chen Monika Figiela Izabela Stepniak Wei Wei Bing-Jie Ni 《材料科学技术学报》2021,77(18):163-168
Artificial catalytic synthesis of ammonia has become a hot research frontier in recent years.It is regarded as a promising approach that may replace the Haber-Bosch process and reduce global carbon dioxide emission.However,it is extremely difficult for the cleavage of nitrogen molecules under ambient con-ditions.Thus the ammonia yield rate is still low and the study is still limited in lab scale.If nitrites or nitrates are used as nitrogen sources,rather than nitrogen gas,the catalytic efficiency can be signifi-cantly improved,and the residual nitrate and nitrite contaminations in water systems can be efficiently eliminated and converted to energy sources at the same time.It is an emerging alternative for artificial ammonia synthesis,while there is not enough focus on the reduction of nitrate and nitrite.Herein,we systematically compared the differences between the reduction of nitrogen and nitrates,as well as listed the challenges in this area.The total conversion rate and energy efficiency of catalytic nitrate reduction are much higher than nitrogen gas reduction due to the much higher solubility and better converting pathway,which might be further enhanced by employing catalysts improvement strategies.Further,we also proposed suitable materials as well as a few future researches needs that may help boost the development of artificial ammonia synthesis using nitrate. 相似文献