Material-specific lateralization of prefrontal activation during episodic encoding and retrieval

Although numerous neuroimaging studies have examined the functional neuroanatomy supporting episodic memory for verbal material, there have been few investigations of non-verbal episodic encoding and retrieval. We used fMRI to directly compare prefrontal activation elicited by verbal and non-verbal material during encoding and during retrieval. Regardless of the mnemonic operation (encoding/retrieval), inferior prefrontal activation lateralized based on material type. Verbal encoding and retrieval resulted in greater left inferior prefrontal activation, whereas non-verbal encoding and retrieval resulted in greater right inferior prefrontal activation. The similarity between inferior prefrontal activity during encoding and during retrieval indicates that these mnemonic operations depend on shared processes mediated by inferior prefrontal regions.     

The effects of aging in delay and trace human eyeblink conditioning.

Normal aging has been shown to impact performance during human eyeblink classical conditioning, with older adults showing lower conditioning levels than younger adults. Previous findings showed younger adults can acquire both delay and trace conditioning concurrently, but it is not known whether older adults can learn under the same conditions. Present results indicated older adults did not produce a significantly greater number of conditioned responses during acquisition, but their ability to time eyeblink responses prior to the unconditioned stimulus was preserved. The decline in eyeblink conditioning that typically accompanies aging has been extended to concurrent presentations of delay and trace conditioning trials. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Multiband,miniaturized, maze shaped antenna with an air‐gap for wireless applications

A novel maze shaped multiband monopole antenna with a miniaturized size of only 6 × 4 × 1.6 mm³ is proposed. To further achieving excellent radiation performances across the desired operating bands, an air‐gap is set between the proposed antenna and system ground. To assess the performances of the antenna, simulations are initially carried out by loading a 1.6 mm thick nonconducting Polycarbonate material (analogous to an air‐gap) between the antenna and system ground, and a simplified equivalent circuit (EC) model of the proposed antenna is also derived. The proposed antenna has excited two different resonance frequencies, in which the lower band (f_L) and upper band (f_U) can yield broad 10‐dB impedance bandwidths of 6.5% (2.37‐2.53 GHz) and 16% (5.05‐5.90 GHz), respectively. Furthermore, desirable gain and radiation efficiency of 2.85 to 6.40 dBi and 57% to 85%, respectively across the two operating bands were also achieved. A practical experiment is also carried out by installing the proposed antenna into a real laptop computer (L412 Think Pad Lenovo).     

An approach to regional wetland digital elevation model development using a differential global positioning system and a custom-built helicopter-based surveying system

Accurate topographic data are critical to restoration science and planning for the Everglades region of South Florida, USA. They are needed to monitor and simulate water level, water depth and hydroperiod and are used in scientific research on hydrologic and biologic processes. Because large wetland environments and data acquisition challenge conventional ground-based and remotely sensed data collection methods, the United States Geological Survey (USGS) adapted a classical data collection instrument to global positioning system (GPS) and geographic information system (GIS) technologies. Data acquired with this instrument were processed using geostatistics to yield sub-water level elevation values with centimetre accuracy (±15 cm). The developed database framework, modelling philosophy and metadata protocol allow for continued, collaborative model revision and expansion, given additional elevation or other ancillary data.     

A low‐profile wideband dual‐polarized antenna with gain enhancement,low gain variations,and low cross polarization for 5G indoor communications

A low‐profile wideband dual‐polarized antenna with high gain, low gain variations, and low cross‐polarization for the fifth generation (5G) indoor distribution system is proposed. By using circular‐thread vase‐shaped structure, a low profile of 0.23λ₀ (λ₀ is the free‐space wavelength at the starting frequency) as well as low gain variation feature can be achieved by the vertically polarized (VP) radiating element. An eight‐way power divider network is employed to feed the horizontally polarized (HP) dipoles so that wideband performance is obtained. Here, eight pairs of arc‐shaped parasitic strips are used to broaden the bandwidth, and eight pairs of director elements are introduced to enhance the gain and reduce the gain variations. In addition, the protruded stubs that are extended from the circular ground plane will help to reduce the cross polarization in the VP direction. Measured results show that a bandwidth of 46.5% (3.3‐5.3 GHz) (S₁₁ < ?10 dB) with a gain of 0.85 ± 0.35 dBi, and another bandwidth of 85.0% (2.5‐6.2 GHz) with a gain of 4.75 ± 1.75 dBi can be realized in the HP and VP directions, respectively. Furthermore, high isolation (>27 dB) and low cross polarization (<?24 dB) can also be attained. Therefore, the proposed antenna is a good candidate for 5G indoor distributed system.     

Dual open‐slot antennas integrated in metal frame and metal case of tablet computer for long‐term evolution applications

Dual open‐slot antennas were integrated in the metal back case and metal frame of a tablet computer for long‐term evolution applications. The single feed dual excitation source antennas were sufficiently narrow (2 mm) for installation between the metal frame and metal back case of the tablet computer. Each antenna had two open‐slot radiators (slot 1 and slot 2) with embedded filter circuits to enable wideband (699‐906 and 1710‐2690 MHz) operation required for LTE applications. The filter circuit values were adjusted to make the impedance more smooth and excite the desired modes. The proposed multiple‐input‐multiple‐output antennas were installed lengthwise on the long sides of the tablet and facing in operate directions. In this configuration, the user hand grip did not interfere with antenna performance, and isolation was improved (> 20 dB). The operating mechanism of the proposed antenna with matching circuits is described in detail. The effects of the user hand grip and the embedded display panel are also discussed.     

Self-Irradiation Damage of a Curium-Doped Titanate Ceramic Containing Sodium-Rich High-Level Nuclear Waste

The polyphase titanate ceramic containing sodium-rich simulated high-level nuclear waste was doped with 0.69 wt% of ²⁴⁴Cm to accelerate long-term self-irradiation due to α decays. α autoradiography showed that α emissions were almost uniformaly distributed throughout the curium-doped samples on a >20-μm scale although micropore surfaces and titanium oxide agglomerates were free of α-emitting nuclides. The phase assemblage of the curium-doped titanate ceramic included freudenbergite and loveringite in addition to the more abundant oxide phases: hollandite, perovskite, and zirconolite. Accumulation of α decays was accompanied by a gradual decrease in density. The increment of density was – 1% after an equivalent age of 5000 yr. Leach tests showed a slight trend toward higher total release of curium with equivalent age. The release of soluble nonradioactive elements (e.g., Na, Cs, Sr, and Ca) in the oldest specimens (equivalent age, 2000 yr) varied from specimen to specimen but, on average, were higher than specimens that had suffered a lower radiation dose.     

Processing difficulties and instability of carbohydrate microneedle arrays

Background: A number of reports have suggested that many of the problems currently associated with the use of microneedle (MN) arrays for transdermal drug delivery could be addressed by using drug-loaded MN arrays prepared by moulding hot melts of carbohydrate materials. Methods: In this study, we explored the processing, handling, and storage of MN arrays prepared from galactose with a view to clinical application. Results: Galactose required a high processing temperature (160°C), and molten galactose was difficult to work with. Substantial losses of the model drugs 5-aminolevulinic acid (ALA) and bovine serum albumin were incurred during processing. While relatively small forces caused significant reductions in MN height when applied to an aluminium block, this was not observed during their relatively facile insertion into heat-stripped epidermis. Drug release experiments using ALA-loaded MN arrays revealed that less than 0.05% of the total drug loading was released across a model silicone membrane. Similarly, only low amounts of ALA (approximately 0.13%) and undetectable amounts of bovine serum albumin were delivered when galactose arrays were combined with aqueous vehicles. Microscopic inspection of the membrane following release studies revealed that no holes could be observed in the membrane, indicating that the partially dissolved galactose sealed the MN-induced holes, thus limiting drug delivery. Indeed, depth penetration studies into excised porcine skin revealed that there was no significant increase in ALA delivery using galactose MN arrays, compared to control (P value < 0.05). Galactose MNs were unstable at ambient relative humidities and became adhesive. Conclusion: The processing difficulties and instability encountered in this study are likely to preclude successful clinical application of carbohydrate MNs. The findings of this study are of particular importance to those in the pharmaceutical industry involved in the design and formulation of transdermal drug delivery systems based on dissolving MN arrays. It is hoped that we have illustrated conclusively the difficulties inherent in the processing and storage of carbohydrate-based dissolving MNs and that those in the industry will now follow alternative approaches.     

Sex differences in the representation of visuospatial functions in the human brain.

Investigated sex differences in the representation of visuospatial functions in the human brain in 20 Ss with right hemisphere stroke and 40 stroke-free control Ss with the Complex Figure Test, Wechsler Adult Intelligence Scale—Revised (WAIS—R) Block Design, and Judgment of Line Orientation. Also, 3 models of sex differences in the representation of visuospatial functions in the human brain were evaluated. The stroke and control groups were composed of equal proportions of men and women. Results suggest that women may be disproportionately impaired in visuospatial functioning relative to men following right hemisphere stroke. It is proposed that visuospatial functions were bilaterally represented in the brains of men, allowing them to rely upon left hemisphere visuospatial systems following right hemisphere stroke, and that these functions were represented in the right hemisphere of women, resulting in their disproportionate impairment despite comparable lesions. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Sniffing and smelling: separate subsystems in the human olfactory cortex

The sensation and perception of smell (olfaction) are largely dependent on sniffing, which is an active stage of stimulus transport and therefore an integral component of mammalian olfaction. Electrophysiological data obtained from study of the hedgehog, rat, rabbit, dog and monkey indicate that sniffing (whether or not an odorant is present) induces an oscillation of activity in the olfactory bulb, driving the piriform cortex in the temporal lobe, in other words, the piriform is driven by the olfactory bulb at the frequency of sniffing. Here we use functional magnetic resonance imaging (fMRI) that is dependent on the level of oxygen in the blood to determine whether sniffing can induce activation in the piriform of humans, and whether this activation can be differentiated from activation induced by an odorant. We find that sniffing, whether odorant is present or absent, induces activation primarily in the piriform cortex of the temporal lobe and in the medial and posterior orbito-frontal gyri of the frontal lobe. The source of the sniff-induced activation is the somatosensory stimulation that is induced by air flow through the nostrils. In contrast, a smell, regardless of sniffing, induces activation mainly in the lateral and anterior orbito-frontal gyri of the frontal lobe. The dissociation between regions activated by olfactory exploration (sniffing) and regions activated by olfactory content (smell) shows a distinction in brain organization in terms of human olfaction.